CAS: 504-88-1; 3-Nitropropionic Acid

该化合物是一种有机化合物,其分子式为C3H5NO4,其特征是,有硝基化合物组(-NO2)附于丙基酸脊柱,该化合物表面是白色晶状固体,在水中溶解,反映其极性,因碳oxylic酸和硝基功能组而产生. 3-硝基丙基丙酸因其作为生物化学抑制剂的作用而闻名,特别是在对代谢途径的研究中,因为它能够抑制丙基脱氢酶,一种涉及柠檬酸循环的酶.这种抑制可导致各种生理影响,使其成为...

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β-Propiolactone 3-iodopropanoic acid propionic acid diethyl (RS)-nitrosuccinate 2,3-bis-phenylhydrazono-propionic acid methyl 3-nitropropionate 1,1,1,3,3,3-hexafluoropropane 3-nitropropan-1-ol

合成工艺路线路线简述

    3-溴丙酸置于silver(I) Nitrite体系中,用 乙醚 作为反应溶剂,以70%的收率获得产物3-硝基丙酸
    参考文献:3-硝基丙醇同系物的合成
    标题:3-硝基丙醇同系物的合成
    摘要:已经开发了几种氧化硝基丙烷的高产途径,包括钯催化的烯丙基碳酸酯的硝基烯丙基化,溴化化合物的硝化和硝基羟醛缩合/氢化序列.
    DOI:10.1055/s-2005-869990

    海关参考信息

    专利信息


    专利号:US-12281398-B2
    优先权日:2022-02-07
    标题:Microfluidic process for the general electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds
    发明人:SCHROER THORSTEN G; LECROY GREGORY E; AGUILA MIGUEL; RODRIGUEZ MAYRA P; DOWNARD TYLER J; MACLEOD BRIANNA L
    权利人:US GOV AIR FORCE; US AIR FORCE
    摘要:A process for the microfluidic electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds comprising the steps ofpumping a solution comprising a compound of Formula Iinto a microfluidic electrochemical reactor in the presence of a base, one of a halide or pseudohalide salt (MY), and a mediator;applying an electrical current through the microfluidic electrochemical reactor; andperforming oxidative addition to create a geminal dipseudohalide or halide-pseudohalide compound of the general Formula II

    专利号:US-6765114-B1
    优先权日:1998-12-29
    标题 :Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid
    发明人:GIZUR TIBOR; LENGYEL ZOLTANNE; SZALAI KRISZTINA
    权利人:RICHTER GEDEON VEGYESZET
    摘要:The invention relates to a new process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid of formula (I) via the new intermedier 1-(nitromethyl)cyclohexyl-acetic acid derivative of formula (II), wherein R represents hydrogen, benzyl group, diphenylmethyl group or C 1 -C 4 alkyl or alkoxy aromatic ring substituted derivatives thereof.

    专利号:US-7109377-B2
    优先权日:1996-10-16
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
    发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
    权利人:HARVARD COLLEGE
    摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

    专利号:US-8765668-B2
    优先权日:2010-06-04
    标 题 :Methods of synthesis of β-aminobutyryl substituted compounds
    发明人:STERK DAMJAN; USTAR MATJAZ; ZLICAR MARKO
    权利人:STERK DAMJAN; USTAR MATJAZ; ZLICAR MARKO; LEK PHARMACEUTICALS
    摘要:The present invention relates to process to prepare β-aminobutyryl compounds having β-amino acid core structural moieties and optionally having γ-phenyl and/or heterocyclic structural moieties. Such compounds are useful as key structure framework of modern drug chemistry.

    专利号:US-4774366-A
    优先权日:1985-01-31
    标题 :Synthesis of geminal dinitro compounds
    发明人:GRAKAUSKAS VYTAUTAS; GARVER LEE C; BAUM KURT
    权利人:US AIR FORCE
    摘要:Geminal dinitro compounds are prepared by reacting an organic nitro compound having a replaceable hydrogen on the carbon to which the nitro group is attached with a source of nitrite ions in the presence of an oxidizing agent and a catalytic amount of an alkali metal ferricyanide.

    专利号:US-7772431-B1
    优先权日:1999-07-27
    标 题 :Performance of energy storage devices: potential areas for dendritic chemistry involvement
    发明人:NEWKOME GEORGE R
    权利人:NEWKOME GEORGE R
    摘要:A compound consists of a fractal-like, plain or organometallic array useful for energy storage devices. A dendrimer useful in the synthesis of the fractal-like compound includes a single ligating moiety bound to a surface of each quadrant of the dendrimer. A method of making metallo-based (macro) molecules includes the steps of combining monomers selected from the group consisting of bipyridal- and terpyridal-based ligands with connecting metals and self assembling macrocycles wherein the monomes are interconnected by the metals.
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