CAS: 55279-30-6; Methyl 3-Aminoisonicotinate

相似化合物

55279-29-3 103698-10-8 152398-05-5

上下游产品

methyl 3-nitropyridine-4-carboxylate methanol 3-Aminopyridine-4-carboxylic acid diazomethyl-trimethyl-silane 3-aminopyridine-4-carboxamide 3-Aminopyridin-4-carboxysaeurehydrazid methyl 3-hydroxypyridine-4-carboxylate methyl 3-amino-2-chloropyridine-4-carboxylate

异烟酸甲酯置于sodium Dithionite,乙醇,五氧化二氮,Sodium Hydrogensulfite体系中,用 甲醇,硝基甲烷,水 作为反应溶剂,化学反应 6.0H,反应生成 3-氨基异烟酸甲酯
参考文献:吡啶底物的friedländer缩合反应合成新型1,7-萘啶
标题:吡啶底物的friedländer缩合反应合成新型1,7-萘啶
摘要:适当的吡啶基化合物(醛或酮)经历弗里德兰德缩合反应反应生成不同的1,7-萘啶的一般能力已得到证明.由3-氨基-4-乙酰基吡啶(6)和酮4(82%)制备2,4-二取代的1,7-萘啶8.也报道了吡啶基底物6的friedländer自缩合反应.获得二聚体产物2-(3-氨基吡啶-4-基)-4-甲基-1,7-萘啶(7),收率为97%.2-芳基-和2,3-二芳基-1,7-萘啶(16,17,18)从3-Aminoisonicotinaldehyde(制备13)和arylketones 4,14和15(28-71%).通过改进的吡啶硝化方法可以容易地获得关键衬底6和13.j.杂环化学.(2011).
DOI:10.1002/jhet.657

专利信息

专利号:CN-111100068-A
优先权日:2019-12-29
标 题 :A kind of method for fast and efficient synthesis of methyl 3-aminoisonicotinate

专利号:US-9328138-B2
优先权日:2011-11-15
标题:HCV NS3 protease inhibitors
发明人：RUDD MICHAEL T; MCCAULEY JOHN; LIVERTON NIGEL; GRISÉ-BARD CHRISTIANE; BROCHU MARIE-CHRISTINE; CHARRON SYLVIE; AULAKH VIRENDER; BACHAND BENOIT; BEAULIEU PATRICK; ZAGHDANE HELMI; HAN YONGXIN; FERRARA MARCO; HARPER STEVEN; SUMMA VINCENZO; CHACKALAMANNIL SAMUEL; VENKATRAMAN SRIKANTH; SHAH UNMESH; VELAZQUEZ FRANCISCO
权利人:MERCK SHARP & DOHME; MSD ITALIA SRL; MERCK CANADA INC
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

专利号:CN-111018775-A
优先权日:2019-12-29
标 题:A kind of high-yield synthesis method of methyl 3-aminoisonicotinate