CAS: 66323-49-7; 3'-Nh2-Ddg

相似化合物

85326-06-3 961-07-9 207121-55-9

上下游产品

3'-amino-3'-deoxythymidine G 5'-O-trityl-2,3'-anhydrothymidine 3'-azido-2',3'-deoxythymidine 3'-tritylamino-2',3'-dideoxyguanosine 2-isobutyryl-3'-NH-trityl-2',3'-dideoxyguanosineN2-isobutyryl-3'-NH-trityl-2',3'-dideoxyguanosine

5'-三苯甲基-2'-脱氧-2,3'-双脱氢胸苷置于吡啶,Ammonium Hydroxide,Phosphate Buffer,叠氮化锂,Cells Of E.Coli Bmt-38,Na-Acetate Buffer,溶剂黄146,三苯基膦体系中,化学反应 35.0H,反应生成 3'-氨基-2',3'-双脱氧鸟苷
参考文献:Chemical-Enzymatic Synthesis Of 3'-Amino-2',3'-Dideoxy-β-D-Ribofuranosides Of Natural Heterocyclic Bases And Their 5'-Monophosphates
标题:Chemical-Enzymatic Synthesis Of 3'-Amino-2',3'-Dideoxy-β-D-Ribofuranosides Of Natural Heterocyclic Bases And Their 5'-Monophosphates
摘要:Treatment Of O-2,3'-Anhydro-5'-O-Trityl Derivatives Of Thymidine (1) And 2'-Deoxyuridine (2) With Lithium Azide In Dimethylformamide At 150 Degrees C Resulted In The Formation Of The Corresponding Isomeric 3'-Azido-2',3'-Dideoxy-5'-O-Trityl-Beta-D-Ribofuranosyl N1-(The Major Products) And N-3-Nucleosides (3/4 And 5/6). 3'-Amino-2',3'-Dideoxy-Beta-D-Ribofuranosides Of Thymidine [thd(3'Nh2)],Uridine [durd(3'Nh2)],And Cytidine [dcyd(3'Nh2)] Were Synthesized From The Corresponding 3'-Azido Derivatives. The Thd(3'Nh2) And Durd(3'Nh2) Were Used As Donors Of Carbohydrate Moiety In The Reaction Of Enzymatic Transglycosylation Of Adenine And Guanine To Afford Dado(3'Nh2) And Dguo(3'Nh2). The Substrate Activity Of Dn(3'Nh2) Vs. Nucleoside Phosphotransferase Of The Whole Cells Of Erwinia Herbicola Was Studied.
DOI:10.1080/15257779408013281

专利信息

专利号:US-9365606-B2
优先权日:2004-07-02
标题 :Synthesis of protected 3′-amino nucleoside monomers
发明人：GRYAZNOV SERGEI M; PONGRACZ KRISZTINA; ZIELINSKA DARIA
权利人:GERON CORP
摘要:Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.

专利号:US-2007065922-A1
优先权日:2005-09-21
标题 :Biocatalytic synthesis of aminodeoxy purine N9-beta-D-nucleosides containing 3-amino-3-deoxy-beta-D-ribofuranose, 3-amino-2,3-dideoxy-beta-D-ribofuranose, and 2-amino-2-deoxy-beta-D-ribofuranose as sugar moieties
发明人：BARAI VLADIMIR N; EROSHEVSKAYA LUDMILLA A; MIKHAILOPULO IGOR A; AZHAYEV ALEX V; LAPINJOKI SEPPO P
权利人:METKINEN OY
摘要:Purine N 9 -β-D-nucleosides containing 3-amino-3-deoxy-β-D-ribofaranose, 3-amino-2,3-dideoxy-β-D-ribofuranose, and 2-amino-2-deoxy-β-D-ribofuranose as sugar moieties are synthesized by biocatalytic transglycosylation of purine bases and the respective 3′-amino-3′-deoxyuridine, 3′-amino-3′-deoxythymidine and 2′-amino-2′-deoxyuridine as donors of the carbohydrate moiety, and the cells of Escherichia coli as a biocatalyst or glutaraldehyde (GA) treated cells of Escherichia coli as a biocatalyst or a mixture of thymidine (uridine) phosphorylase and purine nucleoside phosphorylase.

专利号:US-2024300992-A1
优先权日:2004-07-02
标题:Synthesis of Protected 3'-amino Nucleoside Monomers

专利号:US-10738073-B2
优先权日:2004-07-02
标 题 :Synthesis of protected 3′-amino nucleoside monomers

专利号:US-2009105468-A1
优先权日:2004-07-02
标 题 :Synthesis of Protected 3'-Amino Nucleoside Monomers

专利号:US-2023089101-A1
优先权日:2004-07-02
标题:Synthesis of Protected 3'-amino Nucleoside Monomers