CAS: 700-12-9; 1,2,3,4,5-Pentamethylbenzene

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CAS号2243-32-5 2,3,4,5,6-五甲基苯甲酸 | CAS号503-17-3 2-丁炔 | CAS号4873-09-0 对甲苯磺酸烯丙酯 | CAS号2040-01-9 五甲基苯乙酮 | CAS号67-56-1 甲醇 | CAS号106241-45-6 3-((2,3,5,6-tet... | CAS号56457-41-1 acetyloxy-(2,3,... | CAS号74-87-3 氯甲烷 | CAS号108-95-2 苯酚 | CAS号527-53-7 1,2,3,5-四甲基苯 | CAS号87-85-4 六甲基苯 | CAS号34688-70-5 五甲基苯乙腈 | CAS号52499-94-2 2,3,4,5,6-五甲基苯-1磺酰氯 | CAS号17432-38-1 五甲基苯甲醛 | CAS号484-66-2 2,3,4,5,6-五甲基苯甲醇 | CAS号5082-88-2 Benzene,1,1'-me... | CAS号17432-37-0 2,3,5,6-四甲基苯甲醛 | CAS号5153-40-2 溴五甲基苯 | CAS号484-65-1 2,3,4,5,6-五甲基苄氯

五甲基苯乙酮置于水体系中,用 三氟乙酸 作为反应溶剂,化学反应生成 五甲基苯
参考文献:The Triflic Acid-Catalysed Deacylation And Decarboxylation Of Polymethylbenzenecarbonyl Derivatives Under Mild Conditions
标题:The Triflic Acid-Catalysed Deacylation And Decarboxylation Of Polymethylbenzenecarbonyl Derivatives Under Mild Conditions
摘要:在含有催化量三氟甲磺酸和水的1,2-二氯乙烷中加热,立体阻碍的酰芳烃能够高产率地脱酰基反应生成芳烃.在相同条件下,立体阻碍的芳烃羧酸可以高产率地脱羧反应生成芳烃.
DOI:10.1246/bcsj.62.599

专利信息

专利号:US-2003162992-A1
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
发明人：WATANABE KYOICHI A; DU JINFA
摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

专利号:US-2025282813-A1
优先权日:2021-04-09
标 题 :Pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates
发明人：OKADA YOHEI; SUZUKI HIDEAKI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:A novel pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates are provided. The pseudo solid phase protecting group is represented by formula II wherein: * indicates the point of attachment to an oxygen atom of a hydroxyl moiety of the nucleoside, the nucleotide, the oligonucleotide, or of the conjugate of a nucleoside, a nucleotide or an oligonucleotide to be protected; c is 0 or 1; a is an integer of 1 to 12; R3 is H; R5 is O—R6 or H, where R6 is a C8-C40 aliphatic hydrocarbon group; each of R4 is independently O—R6, where R6 is at each occurrence independently a C8-C40 aliphatic hydrocarbon group; b is 1 to 3; with the proviso that if b is 1, at least one of R3 and R5 is not H; and with the further proviso that the sum of all carbon atoms contained in the R3, R4, and R5 moieties present is larger than 23 and smaller than 200.

专利号:US-12251674-B2
优先权日:2012-11-14
标 题:Substrates, systems, and methods for array synthesis and biomolecular analysis
发明人：RAJASEKARAN JOHN J; JAYARAMAN VASANTH; WANG TIANHAO; BEI KANG; KRISHNAMURTHY HARI KRISHNAN; VEDANTHAM PUNITHA
权利人:VIBRANT HOLDINGS LLC
摘要:Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N→C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

专利号:WO-0207876-A1
优先权日:2000-07-24
标 题 :Methods for optimizing the synthesis of hydrocarbons from synthesis gas
发明人：O'REAR DENNIS J; KIBBY CHARLES L; SCHEUERMAN GEORGIEANNA L
权利人:CHEVRON USA INC
摘要:Methods for discovering optimum catalyst systems for the conversion of syngas to higher molecular weight products via a methanol or other low molecular weight oxygenate intermediate are disclosed. A combinatorial approach is used to identify combinations of catalyst systems useful for performing the reactions. The method can advantageously be used to generate a database of combinations of catalyst systems and/or reaction conditions which provide various product streams, such that as market conditions vary and/or product requirements change, conditions suitable for forming desired products can be identified with little or no downtime. The catalysts are combined in a logical manner, for example, in the form of arrays. The combinations of catalysts can be evaluated using varied reaction conditions, which can provide a) a combinational library of product streams and a database including the combination of catalysts and reaction conditions to provide each product stream and/or b) the optimum combination of catalysts and reaction conditions for obtaining a desired product stream.

专利号:WO-2025082632-A1
优先权日:2023-10-16
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU
权利人:BACHEM HOLDING AG
摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.

专利号:EP-4605403-A1
优先权日:2022-10-17
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.