CAS: 102747-84-2; H-Gln(Trt)-Oh

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上下游产品

CAS号132388-60-4 N-Cbz-N’-三苯甲基-L-谷氨酰胺 | CAS号132327-80-1 Fm°C-N-三苯甲基-L-谷氨酰胺 | CAS号76-84-6 三苯基甲醇 | CAS号56-85-9 L-谷氨酰胺 | CAS号2650-64-8 N-苄氧羰基-L-谷氨酰胺 | CAS号132327-80-1 Fm°C-N-三苯甲基-L-谷氨酰胺 | CAS号132388-69-3 Nα-B°C-Nδ-三苯甲基-... | CAS号132388-65-9 Nα-Fm°C-Nγ-三苯甲游...

三苯基甲醇置于盐酸,Palladium 10% On Activated Carbon,氢气,乙酸酐,溶剂黄146体系中,用 甲醇,水 用作溶剂,化学反应 4.0H,反应生成N'-三苯甲基-L-谷氨酰胺
参考文献:通过酰胺-酯突变探索主链氢键在蛋白质-肽相互作用中的作用
标题:通过酰胺-酯突变探索主链氢键在蛋白质-肽相互作用中的作用
摘要:哺乳动物细胞中最常见的蛋白质-蛋白质相互作用模块之一是突触后密度 95/圆盘大/封闭带 1 (Pdz) 域,它参与支架和信号传导,并成为多种疾病的重要药物靶点.与许多其他蛋白质-蛋白质相互作用一样,Pdz 域家族的相互作用涉及分子间氢键的形成:蛋白质的 C 端或内部线性基序作为 β 链结合,与 Pdz 域形成扩展的反平行 β 折叠.尽管大量工作集中在蛋白质配体的氨基酸侧链的重要性上,但骨架氢键在结合反应中的作用尚不清楚.使用酰胺酯取代来扰乱骨架氢键模式,我们系统地探测了四个不同的 Pdz 结构域和对应于天然蛋白质配体的肽之间的假定骨架氢键.肽配体的三个 C 端酰胺的酰胺酯突变严重影响了与 Pdz 结构域的亲和力,表明氢键对配体结合有显着贡献(结合能的明显变化,δδg = 1.3 至 >3.8 Kcal Mol (-1)).这种亲和力的降低主要是由于解离速率常数的增加,但发现一些酰胺-酯突变
Doi:10.1021/ja402875H

专利信息

专利号:US-11420997-B2
优先权日:2018-04-13
标题:Peptide synthesis method
发明人：SUZUKI HIDEAKI; MUTO SUSUMU; FUJITA SHUJI; KUBO DAISUKE
权利人:JITSUBO CO LTD
摘要:The present invention has an object of shortening the process time and reducing use of a poor solvent for solidifying a carrier (Tag)-peptide component, by removing impurities without conducting solid-liquid separation (condensation, solid-liquid separation and drying operation) of a Tag-peptide component, in an Fmoc method using a Tag for liquid phase peptide synthesis. Provided is the peptide synthesis method that includes the following steps a-d: step a: a carrier-protected amino acid, carrier-protected peptide, or a carrier-protected amino acid amide, and an N-Fmoc-protected amino acid or an N-Fmoc-protected peptide are condensed in an organic solvent or a mixed solution of organic solvents, to obtain an N-Fmoc-carrier-protected peptide, step b: a water-soluble amine is added to the reaction solution after the condensation reaction, step c: the Fmoc group is deprotected from the protected amino group in the presence of a water-soluble amine, and step d: the reaction solution is neutralized by adding an acid, and further, by adding and washing with an acidic aqueous solution, then, by liquid-liquid separation an aqueous layer is removed to obtain an organic layer.

专利号:US-2025066393-A1
优先权日:2021-12-24
标题 :Amine-protecting group
发明人：XU PENGYU; YONEYAMA SHIN
权利人:SYNCREST INC
摘要:An object of the present invention is to provide novel amine-protecting groups useful for the synthesis of special amino acids. Provided is an amine-protecting group.

专利号:US-6660832-B1
优先权日:1999-08-20
标题:Macrocyclic compounds and preparation methods thereof
发明人：JEFFERSON ELIZABETH; SWAYZE ERIC EDWARD
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention is directed to macrocyclic compounds of the formula (I)wherein Q, X, R1 and R5 are as defined herein. Compounds of the invention are useful for therapeutic and prophylactic treatment of bacterial infection in mammals. Solid phase synthetic procedures are provided effecting synthesis of the macrocyclic rings attached to a solid support.

专利号:CN-113845586-B
优先权日:2021-11-14
标 题 :A method for liquid-phase synthesis of acetyl hexapeptide-8

专利号:US-RE49961-E
优先权日:2016-10-21
标 题:Solid phase peptide syntheses
发明人：COLLINS JONATHAN M
权利人:CEM CORP
摘要:An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.

专利号:US-2024124517-A1
优先权日:2020-12-25
标题:Method for producing peptide compound containing n-substituted-amino acid residue
发明人：MORITA YUYA; NOMURA KENICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:An object of the present invention is to provide a method for efficiently producing a high-purity peptide compound with a high yield. It has been found that the object can be achieved by supporting a peptide on a solid phase synthesis resin prior to a first elongation reaction in a solid phase process.