CAS: 104863-67-4; 2,2,2-Trifluoro-N-Methoxy-N-Methylacetamide

相似化合物

6638-79-5 78191-00-1 32117-82-1

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CAS号6638-79-5 二甲羟胺盐酸盐 | CAS号407-25-0 三氟乙酸酐(TFAH) | CAS号354-32-5 三氟乙酰氯 | CAS号1117-97-1 甲氧基甲基胺 | CAS号104863-72-1 Ethanone, 1-(1,... | CAS号341-39-9 2,2,2-三氟-1-(邻甲苯... | CAS号394-59-2 4-(三氟乙酰基)甲苯 | CAS号434-45-7 α,α,α-三氟苯乙酮 | CAS号30724-22-2 3-(三氟甲氧基)苯乙酮 | CAS号711-38-6 2,2,2-三氟-4'-甲氧基苯乙酮 | CAS号132719-10-9 3',5'-二甲基-2,2,2... | CAS号130336-16-2 3',5'-二氯-2,2,2-三氟苯乙酮 | CAS号16184-89-7 4'-溴-2,2,2-三氟苯乙酮 | CAS号174734-34-0 5-甲氧基-2-(三氟甲基)-1H-吲哚

二甲羟胺盐酸盐置于吡啶,三氟乙酸酐体系中,用 二氯甲烷 用作溶剂,化学反应生成N-甲氧基-N-甲基-2,2,2-三氟乙酰胺
参考文献:Glucocorticoid Mimetics,Methods Of Making Them,Pharmaceutical Compositions,And Uses Thereof
标题:Glucocorticoid Mimetics,Methods Of Making Them,Pharmaceutical Compositions,And Uses Thereof
摘要:一种符合formula (Ia)或formula (Ib)1的化合物,其中r1,R2,R3,R4,R5,R6,R7和r8如本文所定义,或其互变异构体,前药,溶剂合物或盐;含有这些化合物的药物组合物,以及使用这些化合物调节糖皮质激素受体功能,治疗由糖皮质激素受体功能介导或以炎症,过敏或增生过程为特征的疾病状态或病情的方法.

专利信息

专利号:US-7179919-B2
优先权日:2004-03-18
标 题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：SONG JINHUA J; TAN ZHULIN; YEE NATHAN K; SENANAYAKE CHRIS HUGH; XU JINGHUA; GALLOU FABRICE
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein.

专利号:US-2011130567-A1
优先权日:2009-06-03
标题 :Steroselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：FANDRICK DANIEL R; REEVES JONATHAN T; SONG JINHUA J; TAN ZHULIN; QU BO; YEE NATHAN K; RODRIGUEZ SONIA
权利人:BOEHRINGER INGELHEIM INT
摘要:A process for stereoselective synthesis of a compound of Formula (X) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl,n wherein each substituent group of R 1 is optionally independently substituted with one to three substituents selected from C 1 -C 3 alkyl, C 1 -C 3 alkoxy, phenyl, and alkoxyphenyl; n n R 2 and R 3 are each independently C 1 -C 5 alkyl; R 4 is C 1 -C 5 alkyl optionally independently substituted with one to three substituent groups,n wherein each substituent group of R 4 is independently C 1 -C 3 alkyl, hydroxy, halogen, amino, or oxo; and n R 5 is a heteroaryl group substituted with one to three substituent groups,n wherein each substituent group of R 5 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonylamino, aminosulfonyl, C 1 -C 5 alkylaminosulfonyl, C 1 -C 5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or C 1 -C 5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone.

专利号:US-2011130578-A1
优先权日:2009-06-03
标题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：FANDRICK DANIEL R; KUZMICH DANIEL; REEVES JONATHAN T; SONG JINHUA J; TAN ZHULIN; LEE THOMAS
权利人:BOEHRINGER INGELHEIM INT
摘要:A process for stereoselective synthesis of a compound of Formula (X) or Formula (X′) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl, C 1 -C 5 alkoxy, C 1 -C 5 alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, C 1 -C 5 alkoxycarbonylamino, aminosulfonyl, C 1 -C 5 alkylaminosulfonyl, C 1 -C 5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, nitro, or C 1 -C 5 alkylthio wherein the sulfur atom is oxidized to sulfoxide or sulfone, and n R 2 and R 3 are each independently hydrogen or C 1 -C 5 alkyl.

专利号:US-2005209488-A1
优先权日:2004-03-18
标 题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols

专利号:WO-2010141331-A2
优先权日:2009-06-03
标 题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols

专利号:CA-2557896-A1
优先权日:2004-03-18
标题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols