CAS: 19171-19-8; 4-Amino-2-(2,6-Dioxopiperidin-3-yl)Isoindoline-1,3-Dione

上下游产品

CAS号19171-18-7 4-硝基沙利度胺 | CAS号24666-56-6 3-氨基-2,6-哌啶二酮盐酸盐 | CAS号6946-22-1 3-氨基邻苯二甲酸盐酸盐 | CAS号641-70-3 3-硝基邻苯二甲酸酐 | CAS号2650-64-8 N-苄氧羰基-L-谷氨酰胺 | CAS号24666-55-5 (2,6-二氧代哌啶-3-基)...

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-Dioxoisoindolin-4-yl)Acetamide置于sodium Hydroxide体系中,用 水,乙腈 用作溶剂,化学反应 8.0H,以95.6%的收率获得泊马度胺
参考文献:3-氨基-N-(2,6-二氧代-3-哌啶基)-邻苯二甲 酰亚胺化合物的制备方法
标题:3-氨基-N-(2,6-二氧代-3-哌啶基)-邻苯二甲 酰亚胺化合物的制备方法
摘要:本发明公开了一种3‑氨基‑n‑(2,6‑二氧代‑3‑哌啶基)‑邻苯二甲酰亚胺化合物的制备方法,3‑氨基‑n‑(2,6‑二氧代‑3‑哌啶基)‑邻苯二甲酰亚胺化合物为式(ⅰ)化合物,或其药学上可接受的盐,溶剂化物,多晶型物或立体异构体,式(ⅰ)化合物分子结构式为:其包括:将式(ⅱ)化合物在溶剂中,且在酸或碱存在条件下进行水解反应,式(ⅱ)化合物分子结构式为:式(ⅱ)化合物溶解性强,容易发生水解,不用进行金属催化剂的还原反应以及产品的进一步纯化等步骤,进而使得制备步骤简单,且产品收率和纯度都较高,适合大规模工业化生产.

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-2021220331-A1
优先权日:2016-05-03
标题:Inhibitors of ires-mediated protein synthesis
发明人：GERA JOSEPH F; LICHTENSTEIN ALAN; JUNG MICHAEL E; LEE JIHYE; HOLMES BRENT; BENAVIDES-SERRATO ANGELICA
权利人:UNIV CALIFORNIA; THE UNITED STATE GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
摘要:This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

专利号:US-8828984-B2
优先权日:2012-11-19
标题:Gold(III) complexes containing N-heterocyclic carbene ligand, synthesis, and their applications in cancer treatment and thiol detection
发明人：CHE CHI MING; ZOU TAOTAO
权利人:UNIV HONG KONG; UNIV HONG KONG
摘要:Provided herein is a method of synthesis of Au(III)-NHC complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Au(III)-NHC complexes. Also provided is method of detecting thiol in a biological system. The Au(III)-NHC complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo.

专利号:US-10577387-B1
优先权日:2018-08-09
标题 :Platinum (II) complexes containing N-heterocyclic carbene ligand and pincer ligands, synthesis, and their applications in cancer treatment
发明人：CHE CHI MING; Fung Sin Ki; Chen tian feng
权利人:UNIV HONG KONG
摘要:Provided herein is a method of synthesis of Pt(II) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Pt(II) complexes. Also provided is a method of detecting the Pt(II) complex in a biological system. Also provided is a method of making the Pt(II) complex The Pt(II) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.

专利号:US-11286271-B2
优先权日:2018-07-31
标 题 :Iridium (III) complexes containing N-heterocyclic carbene ligand, synthesis, and their use thereof in cancer treatment
发明人：CHE CHI MING; LAM TSZ LUNG; TONG KA CHUNG
权利人:UNIV HONG KONG
摘要:Provided herein are Ir(III) complexes comprising N-heterocyclic carbene ligand, method of synthesis of the Ir(III) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Ir(III) complexes under both dark and light conditions. Also provided is a method of detecting the Ir(III) complex in a biological system. Also provided is a method of making the Ir(III) complex. The Ir(III) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.