Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于铁粉,溶剂黄146体系中,化学反应生成3-氨基-4-氯吡啶 参考文献:Den Hertog Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1950,Vol. 69,P. 673,690 标题:Den Hertog Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1950,Vol. 69,P. 673,690
专利号:US-5077408-A 优先权日:1989-09-20 标 题 :Process for the synthesis of oxazolopyridine compounds 发明人:GUILLAUMET GERALD; FLOUZAT CHRISTINE 权利人:SCIENCE ORGANISATION 摘要:Process for the synthesis of compounds of formula (I): ##STR1## their pyridinium salts and N-oxides, in which formula: the nitrogen of the pyridine ring is situated in the α-, β-, γ- or δ-position with respect to the ring junction; n R 1 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, substituted or unsubstituted amino, phenyl or cyano group; n 0≦m≦2; n R 2 represents a lower alkyl or cycloalkyl group, a 5- or 6-membered heterocycle containing 1 or 2 hetero atoms, substituted or otherwise, or an aryl group ##STR2## such that: R 3 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, phenyl, substituted or unsubstituted sulfonyl, cyano, thioalkyl, substituted or unsubstituted amino, substituted or unsubstituted sulfinyl, mercapto, hydroxyl or ester group, n 0≦n≦5 n employing trimethylsilyl polyphosphate (PPSE) as a cyclization agent and enabling the compounds of formula (I) to be obtained in virtually quantitative yields. The compounds of formula I have anti-inflammatory, analgesic, and antipyretic activity.
专利号:NZ-235388-A 优先权日:1989-09-20 标 题:Process for the synthesis of oxazolopyridines
专利号:IE-903385-A1 优先权日:1989-09-20 标 题 :New process for the synthesis of oxazolopyridine derivatives