CAS: 37247-10-2; 3,7-Bis(Dimethylamino)Phenothiazin-5-Ium Chloride Mixt. With 3-(Dimethylamino)-7-(Methylamino)Phenothiazin-5-Ium Chloride(1:1)

专利信息

专利号:US-8691979-B2
优先权日:2009-05-12
标题 :Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants
发明人：LARCH CHRISTOPHER PAUL; STOREY JOHN MERVYN DAVID; WILLIAMSON CRAIG; MARSHALL COLIN; KEMP STEVEN JOHN
权利人:LARCH CHRISTOPHER PAUL; STOREY JOHN MERVYN DAVID; WILLIAMSON CRAIG; MARSHALL COLIN; KEMP STEVEN JOHN; WISTA LAB LTD
摘要:Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compoundsâ€?) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).

专利号:US-9765042-B2
优先权日:2013-10-07
标题 :Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
发明人：SINCLAIR JAMES PETER; NICOLL SARAH LOUISE; STOREY JOHN MERVYN DAVID
权利人:WISTA LAB LTD
摘要:Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compoundsâ€?) including Methythioninium Chloride (MTC) (also known as Methylene Blue) are provided.

专利号:US-7790881-B2
优先权日:2004-09-23
标 题:Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
发明人：STOREY JOHN MERVYN DAVID; SINCLAIR JAMES PETER; MARSHALL COLIN; TAN HAN WAN
权利人:WISTA LAB LTD
摘要:This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compoundsâ€?) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases. Wherein: each of R 1 and R 9 is independently selected from: —H; C 1-4 alkenyl; and halogenated C 1-4 alkyl; each of R 3NA and R 3NB is independently selected from: C 1-4 alkyl; C 2-4 alkenyl; and halogenated C 4-1 alkyl; each of R 7NA and R 7NB is independently selected from: C 1-4 alkyl; C 2-4 alkenyl; and halogenated C 1-4 alkyl; and X is one or more anionic counter ions to achieve electrical neutrality.

专利号:US-10047062-B2
优先权日:2013-10-07
标题 :Methods of chemical synthesis of Diaminophenothiazinium compounds including methylthioninium chloride (MTC)

专利号:US-2016251325-A1
优先权日:2013-10-07
标题:Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (mtc)

专利号:EP-2430007-B1
优先权日:2009-05-12
标题:Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants