CAS: 39478-78-9; 5-Bromo-2-Methylaniline

上下游产品

4-bromo-2-nitrotoluene hydrogenchloride 4-Methyl-3-nitroanilin iron 2,4-dibromotoluene 5-bromo-2-methylphenol 5'-bromo-2'-methylacetanilide 5-bromo-8-methyl-quinoline

4-溴-2-硝基甲苯置于tin(II) Chloride Dihdyrate体系中,用 乙酸乙酯 作为反应溶剂,化学反应 4.0H,以97%的收率获得产物5-溴-2-甲基苯胺
参考文献:葫芦[7]尿/客体组合中的细微"超分子支撑效应" †
标题:葫芦[7]尿/客体组合中的细微"超分子支撑效应" †
摘要:已经制备了在3位带有二甲基ulf基团和在4位带有3个不同取代基(h,F和ch 3)的联苯衍生物作为探针,以测试"超分子支撑"概念的有效性.我们将后者定义为取代基对分子间识别的影响,由相邻单元改变.在这种情况下,4-取代基对3-二甲基s基团施加一定的压力,并控制它们的顺式和反式构象的比例.作为游离物种,带有4-H和4-F取代基的联苯以近似等摩尔的顺式和反式构象异构体混合物形式存在,而带有4-Ch 3基团的联苯支架采用抗-Conformation独占.然后,3-二甲基ulf取代基与葫芦[7] Uril(cb [7])的羰基化门户之一相互作用,其构象影响大环腔内客体的位置,从而验证了我们的"超分子支撑"模型.然而,令人惊讶的是,尽管在cb [7]门户的合成或反式中呈现出非常不同的电子密度,但对cb [7]的结合亲和力几乎不受4-取代基的性质和相邻sulf基团构象的影响.构象.发现溶剂化可显着平滑
DOI:10.1039/c3Ob40250A

专利信息

专利号:US-2006058532-A1
优先权日:2004-09-10
标 题:Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives
发明人：CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
权利人:CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
摘要:The invention is directed to a process of synthesizing compounds of formula (VI): n n nwherein R 1- R 9 , R 3′ , R 4′ and Y are as set forth in the specification, and said method is useful for large scale synthesis thereof. The invention is also directed to useful intermediates for synthesizing the compounds of formula (VI) and processes of preparing said intermediates.

专利号:US-10669425-B2
优先权日:2017-05-02
标题 :One-pot synthesis of reactive deep black
发明人：VRIEZEMA DENNIS MANUEL; KLEINE SIGRID ELISABETH; SMALLEGANGE MARTIN JAN
权利人:SPGPRINTS B V
摘要:A one-pot synthesis for preparing an aqueous reactive black mixture includes a) dissolving 2-[(4-aminophenyl)sulfonyl]ethanesulfonic acid (vinyl sulphone parabase ester) in water; b) diazotizing the dissolved vinyl sulphone parabase ester using excess nitrous acid or using excess nitrite and an acid, resulting in a diazonium salt and remaining nitrous acid; c) quenching the remaining nitrous acid with sulfamic acid; d) coupling the diazonium salt of step c) with 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid (H-acid) until the reaction is complete, resulting in Reactive Black 5 (RB 5) and remaining diazonium salt, e) coupling the remaining diazonium salt with 7-acetamido-4-hydroxy-2-naphthalenesulfonic acid (acetyl-J-acid) until the reaction is complete resulting in Reactive Orange 78 (RO 78); and f) obtaining the aqueous reactive black mixture.

专利号:US-5144015-A
优先权日:1990-12-21
标 题 :Synthesis of pyrazole dyes
发明人：CHAPMAN DEREK D
权利人:EASTMAN KODAK CO
摘要:A process for preparing a 1-alkyl-3-secondary or tertiary alkyl-4-cyano-pyrazol-5-yl azo dye or a 1-alkyl-3-aryl-4-cyano-pyrazol-5-yl azo dye comprising: n a) reacting a 3-secondary or tertiary alkyl-4-cyano-5-amino pyrazole or a 3-aryl-4-cyano-5-amino pyrazole with a diazotizing reagent to form a pyrazol-5-yl diazonium salt; n b) allowing said diazonium salt to react with an aromatic coupling component to form a 3-secondary or tertiary alkyl-4-cyano-pyrazol-5-yl azo dye or a 3-aryl-4-cyano-pyrazol-5-yl azo dye; and n c) reacting the product of step b) with an aklylating agent in the presence of a base to form a 1-alkyl-3-secondary or tertiary alkyl-4-cyano-pyrazol-5-yl azo dye or a 1-alkyl-3-aryl-4-cyano-pyrazol-5-yl azo dye.

专利号:US-4467117-A
优先权日:1983-02-07
标题 :Process for the production and purification of 2,4,4'-trichloro-2'-hydroxydiphenylether
发明人：LUND RICHARD B; BROWN GLENN W
权利人:CIBA GEIGY CORP
摘要:An improved synthesis of the bacteriostat 2,4,4'-trichloro-2'-hydroxydiphenylether is disclosed wherein the hydrolysis after diazotization is carried out at 175°-180° C. to increase the yield and reaction rate. The hydrolyzed product is distilled after neutralization to remove the major portion of undesirable colored products and phenolics. The distillate is then extracted with tetrachlorethylene to separate the product from non-phenolic by-products including the 25-28% 2,4,8-trichlorodibenzofuran which are present. The final product of the process then meets F.D.A. and commercial standards for use in soaps and cosmetics.

专利号:US-9688609-B2
优先权日:2014-11-04
标题:Telescoping synthesis of 2-methoxymethyl-P-phenylenediamine
发明人：ABEL HEIKE GERTRUD; OSAN ARMIN; GARRETT GARRY STEVEN; GARDLIK JOHN MICHAEL; MURPHY BRYAN PATRICK; SPECKBACHER MARKUS; WEBER INGO REINHOLD
权利人:NOXELL CORP
摘要:A telescoping process for the preparation of 2-methoxymethyl-p-phenylenediamine, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely 2-hydroxymethylaniline.

专利号:US-9695109-B2
优先权日:2014-11-04
标题:Telescoping synthesis of 2-methoxymethyl-p-phenylenediamine
发明人：ABEL HEIKE GERTRUD; OSAN ARMIN; SPECKBACHER MARKUS; WEBER INGO REINHOLD; GARRETT GARRY STEVEN
权利人:NOXELL CORP
摘要:A telescoping process for the preparation of 2-methoxymethyl-p-phenylenediamine, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely 2-methoxymethylaniline.