CAS: 39891-05-9; (6-Fluoropyridin-3-yl)Methanol

相似化合物

1427-06-1 677728-92-6 403-45-2

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2-fluoro-5-pyridylmethyl chloride 2-fluoro-5-methylpyridine 6-fluoronicotinic acid 2-fluoro-5-formylpyridine (5-bromo-6-fluoropyridin-3-yl)methanol 2-fluoro-5-formylpyridine 4-{5-[(Z)-2-fluoro-2-{1-[(6-fluoropyridin-3-yl)methyl]-5-methyl-1H-pyrazol-3-yl}vinyl]pyridin-2-yl}-2,6-dimethylmorpholine (6-fluoropyridin-3-yl)methyl methanesulphonate

2-氟-5-甲基吡啶置于盐酸,N-氯代丁二酰亚胺,Potassium Carbonate,过氧化苯甲酰体系中,用 水,溶剂黄146,乙腈 用作溶剂,化学反应生成2-氟-5-羟甲基吡啶
参考文献:Efficient Pyridinylmethyl Functionalization: Synthesis Of 10,10-Bis[(2-Fluoro-4-Pyridinyl)Methyl]-9(10H)-Anthracenone (Dmp 543),An Acetylcholine Release Enhancing Agent
标题:Efficient Pyridinylmethyl Functionalization: Synthesis Of 10,10-Bis[(2-Fluoro-4-Pyridinyl)Methyl]-9(10H)-Anthracenone (Dmp 543),An Acetylcholine Release Enhancing Agent
摘要:2-Fluoro-4-Methylpyridine (3) Is Efficiently Functionalized By Chlorination,Hydrolysis And Methane-Sulfonylation Into The Novel Alkylating Agent 7. This Mesylate Is Used For The Bisalkylation Of Anthrone Under Carefully Defined Conditions To Prepare The Cognition Enhancer Drug Candidate 1. This Process Proceeds In Up To 37% Overall Yield And Is Adaptable For Large Scale Synthesis.
Doi:10.1021/jo9804339