CAS: 430-99-9; 2-Fluoroacrylic Acid

相似化合物

2343-89-7 760-80-5 74893-46-2

上下游产品

CAS号332061-81-1 2-chloro-2-fluo... | CAS号57965-29-4 (S)-2-氟丙酸 | CAS号79-10-7 丙烯酸 | CAS号760-80-5 2-氟代丙烯酸乙酯 | CAS号425-83-2 1-diazo-2-oxo-3... | CAS号50-00-0 甲醛 | CAS号758-93-0 trifluorovinyl ... | CAS号815-49-6 2-fluoro-3-chlo... | CAS号433-63-6 dichloro-2-fluo... | CAS号598-73-2 溴代三氟代乙烯 | CAS号16522-55-7 2-氟丙烯酰氯 | CAS号664342-20-5 N-benzyl-2-fluo...

2-Fluoro-3-Chloropropanoic Acid置于sodium Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应生成 2-氟丙烯酸
参考文献:Boguslovskaya,L.S. Et Al.,Journal Of Organic Chemistry Ussr (English Translation),1969,Vol. 5,P. 1879-1883
标题:Boguslovskaya,L.S. Et Al.,Journal Of Organic Chemistry Ussr (English Translation),1969,Vol. 5,P. 1879-1883

专利信息

专利号:US-7304191-B2
优先权日:2000-08-07
标 题:Process for the synthesis of fluoroorganic compounds
发明人：MATHIEU VERONIQUE; JANSSENS FRANCINE; FRANKLIN JAMES
权利人:SOLVAY
摘要:The present invention relates to a fluorination method for the synthesis of halofluoroorganic compounds which can be used, inter alia, as precursors in the synthesis of 2,3-unsaturated fluoroorganic carbonyl compounds comprising a fluorine substituent in the 2 position.

专利号:WO-2017109658-A1
优先权日:2015-12-23
标 题:Process for the synthesis of patiromer
发明人：GABOARDI MAURO; PRENDIN RICCARDO; CASTALDI MARTA; CASTALDI GRAZIANO
权利人:RJW PHARMA LLC
摘要:The present invention relates to a process for the synthesis of Patiromer, an active ingredient used in the treatment of hyperkalemia in adults.

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:WO-2025132814-A1
优先权日:2023-12-21
标 题:Novel synthesis of methyl-2-fluoroacrylate
发明人：BRUNKE JESSICA; FISCHER MICHAEL; WÖSSNER JAN STEPHAN
权利人:VIFOR INT AG
摘要:The present invention relates to novel synthesis methods of methyl 2-fluoroacrylate (MFA) which is a key precursor for the production of Veltassa® (Patiromer). The methods according to the invention are conducted by reacting an α-substituted β-hydroxy propionic acid derivative (I) via one or more intermediate steps involving one or more α-, β-substituted propionic acid derivatives (II) to obtain MFA (III).

专利号:WO-8911470-A1
优先权日:1988-05-27
标题 :Dihalogeno-3,3 fluoro-2 propenols-1, preparation method and utilization for the synthesis of fluoro-2 acrylic and dihalogeno-3,3 fluoro-2 acrylic acids and their derivatives
发明人：WAKSELMAN CLAUDE; NGUYEN THOAI; MOLINES HUGUETTE
权利人:CENTRE NAT RECH SCIENT
摘要:The invention relates to dihalogeno-3,3 fluoro-2 propenol-1 having the formula X?1X?2C=CF-CH2?OH (I), wherein X?1 and X?2, which may be identical or different, represent a fluorine, a chlorine or a bromine atom providing that X?1 and X?2 do not represent both a chlorine atom. These compounds may be prepared by reaction of an alcohol having the formula HCH?1X?2-CFX?3-CH2?OH (II), X?1 and X?2 have the meaning given hereabove and X?3 is a fluorine, chlorine or bromine atom, similar to or different from X?1 and/or X?2, with an organolithian compound. They may be used to prepare halides of the fluoro-2 acrylic acid and of the dihalogeno-3,3 fluoro-2 acrylic acids or their esters.

专利号:US-2024400558-A1
优先权日:2021-09-09
标题 :Processes and intermediates for synthesis of adagrasib
发明人：SCATTOLIN THOMAS; CHEN CHENG; GHARBAOUI TAWFIK; GAN YONGHONG; ACHMATOWICZ MICHAL; SNEAD DAVID
权利人:MIRATI THERAPEUTICS INC
摘要:The present invention relates to improved synthetic routes of synthesizing adagrasib. The invention also provides intermediates used in the provided synthetic routes.