CAS: 53100-44-0; Boc-Pyr-Oh

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CAS号113400-36-5 N-叔丁氧羰基-L-焦谷氨酸苄酯 | CAS号108963-97-9 4-nitrobenzyl L... | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号94885-52-6 (S)-5-氧代吡咯烷-2-羧酸苄酯 | CAS号81658-25-5 B°C-L-焦谷胺醇 | CAS号98-79-3 L-焦谷氨酸 | CAS号87605-35-4 4-nitrobenzyl L... | CAS号56-86-0 L-谷氨酸 | CAS号91229-91-3 (S)-N-叔丁氧羰基-2-吡... | CAS号98-79-3 L-焦谷氨酸 | CAS号24305-27-9 普罗瑞林 | CAS号81658-25-5 B°C-L-焦谷胺醇 | CAS号108963-96-8 B°C-L-焦谷氨酸甲酯

L-焦谷氨酸置于palladium On Activated Charcoal 4-二甲氨基吡啶,氢气,三乙胺体系中,用 乙酸乙酯,丙酮,乙腈 作为反应溶剂,化学反应 290.0H,反应生成 Boc-L-焦谷氨酸
参考文献:Stereospecific Synthesis Of (2S,4R)-[5,5,5-2H3]Leucine
标题:Stereospecific Synthesis Of (2S,4R)-[5,5,5-2H3]Leucine
摘要:首次顺式特异性化学合成了一个标记在一个非对映体甲基基团的氨基酸(2S)-亮氨酸样品,采用(2S)-焦谷氨酸作为手性模板.这一成果已被用来开发一种方法,以在蛋白质的^1H NMR光谱中将共振频率分配给亮氨酸残基的非对映体甲基基团.
DOI:10.1039/p19960000507

专利信息

专利号:WO-2023030277-A1
优先权日:2021-08-30
标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD
摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.

专利号:US-3988307-A
优先权日:1974-09-06
标题 :Solid phase synthesis of peptides with carboxyl-terminal amides
发明人：GROSS ERHARD
权利人:US HEALTH
摘要:The method of utilizing α,β-unsaturated amino acids, acyl, and N-acyl derivatives as linking agents in the solid phase synthesis of peptides with the corresponding production of carboxyl terminal amides. Preferred unsaturated amino acids are dehydroalanine and dehydrobutyrine which are constituents in naturally occurring amides such as nisin and subtilin. The synthesis follows conventional lines of R. B. Merrifield et al including blocking of the amino nitrogen, with the exception that the release agent contains an amount of water equimolar to the reactant α,β-unsaturated amino acid.

专利号:WO-2023030278-A1
优先权日:2021-08-30
标题:Full-liquid-phase synthesis method for reelin drug
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN SANTAI PHARMACEUTICAL CO LTD
摘要:Provided is a full-liquid-phase synthesis method for a reelin drug, belonging to the technical field of medicine synthesis. A liquid-phase method is used to synthesize 'Trp-Ser-Tyr' fragments, 'R5-Leu' fragments, 'PYR-His' fragments, and 'Arg-Pro-Gly-NH2' respectively, wherein R=D-Trp, Gly or D-2-NAL; and a reelin drug is synthesized in a '3+2+2+3' fragment condensation manner. The method has the characteristics of low reaction costs, non use of toxic reagents, a high product yield, and high purity, and is environmentally friendly, and is thus suitable for large-scale production.

专利号:WO-9610036-A1
优先权日:1994-09-27
标题 :A process for the quantitative synthesis of 3-(l-pyroglutamyl)-l-thiazolidine-4-carboxylic acid and derivatives thereof

专利号:US-7910774-B2
优先权日:2004-08-31
标题:Alternative synthesis of renin inhibitors and intermediates thereof

专利号:IT-MI941955-A1
优先权日:1994-09-27
标 题:'QUANTITATIVE SYNTHESIS OF 3- (L-PIROGLUTAMIL) -L-THIAZOLIDIN-4- CARBOXYLIC ACID AND ITS DERIVATIVES'