CAS: 5381-20-4; Benzo[b]Thiophene-3-Carbaldehyde

上下游产品

CAS号7342-82-7 3-溴苯并噻吩 | CAS号201230-82-2 carbon monoxide | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号5312-73-2 二氯甲基丁醚 | CAS号95-15-8 苯并噻吩 | CAS号4885-02-3 1,1-二氯甲醚 | CAS号50-00-0 甲醛 | CAS号3216-47-5 2-氯-3-甲基苯并(b)噻吩 | CAS号100-97-0 乌洛托品 | CAS号122-51-0 原甲酸三乙酯 | CAS号39827-12-8 1-苯并噻吩-3-羰酰氯 | CAS号5381-24-8 3-羟甲基苯并噻吩 | CAS号5381-25-9 苯并[b]噻吩-3-羧酸 | CAS号95-15-8 苯并噻吩 | CAS号24434-84-2 苯并[b]噻吩-3-甲腈 | CAS号3216-47-5 2-氯-3-甲基苯并(b)噻吩 | CAS号2132-80-1 4,4-二甲氧基联苯 | CAS号693228-22-7 2-(4-methoxyphe... | CAS号26461-80-3 3-(苯并[b]噻吩-3-基)丙酸 | CAS号239-35-0 地托咪定

苯并噻吩置于正丁基锂,溴体系中,用 乙醚,正己烷,氯仿 作为反应溶剂,化学反应 4.5H,反应生成 3-甲醛苯并噻吩
参考文献:通过互补羰基活化统一合成多环生物碱**
标题:通过互补羰基活化统一合成多环生物碱**
摘要:已经开发出用于合成多环生物碱的互补双羰基活化策略.成功的应用包括四环生物碱骆驼蓬菌素和骆驼蓬菌素,五环吲哚喹啉西啶生物碱去甲代拜林和八环β-咔啉生物碱peganumine A的合成.后者的合成具有无保护基组装和不对称二磺酰亚胺催化环化的特点.此外,还实现了 Hirsutine,Deplancheine,10-Desbromoarborescidine A 和 Oxindole 生物碱钩藤碱和异钩藤碱的正式合成.最终完成了小檗碱生物碱ilicifoline B的简捷合成.
DOI:10.1002/anie.202102518

专利信息

专利号:US-2011152313-A1
优先权日:2008-06-20
标题 :Synthesis of ageladine a and analogs thereof
发明人：KARUSO PETER HELMUTH; SHENGULE SUDHIR RAMNATHRAO
权利人:UNIV MACQUARIE
摘要:The invention describes a one pot process for synthesizing a compound of structure (I), or a tautomer thereof. A compound of structure (II), or a tautomer thereof, and an aldehyde of structure R d CHO are condensed to form a condensation product. The resulting condensation product is then oxidized in the same reaction mixture to produce the compound of structure (I) or a tautomer thereof.

专利号:US-11161823-B2
优先权日:2019-03-11
标 题 :Anticancer 1,3-dioxane-4,6-dione derivatives and method of combinatorial synthesis thereof
发明人：ISLAM IMADUL; AL-KAYSI RABIH O; BOUDJELAL MOHAMED; ALI RIZWAN; NEHDI ATEF; ALGHANEM BANDAR
权利人:NAT GUARD HEALTH AFFAIRS; KING SAUD BIN ABDULAZIZ UNIV FOR HEALTH SCIENCES; KING ABDULLAH INTERNATIONAL MEDICAL RES CENTER; KING ABDULLAH INETRNATIONAL MEDICAL RES CENTER
摘要:Compounds, methods of synthesis, and methods of cancer treatment by arylidene-1,3-dioxane-4,6-diones. A Meldrum's acid-based chemistry and hybrid solid-liquid method. The method includes protection of ketone and aldehyde components and simultaneous immobilization on the solid phase, introduction of substituents, grafts and derivatives compatible with the protection, detachment and restoration of active carbonyl reactivity, reaction of ketone library with malonate, reacting of the products with the aldehyde library in liquid phase and separation of the products by preparative HPLC.

专利号:WO-2009152584-A1
优先权日:2008-06-20
标题 :Synthesis of ageladine a and analogs thereof

专利号:US-10829464-B2
优先权日:2016-11-23
标题 :Benzoheterocyclic alkylamine compounds and use thereof
发明人：LI JIAN; LAN LEFU; LI BAOLI; CHEN FEIFEI; NI SHUAISHUAI; LIU YIFU; WEI HANWEN; MAO FEI; ZHU JIN
权利人:UNIV EAST CHINA SCIENCE & TECH; SHANGHAI INST MATERIA MEDICA CAS
摘要:Disclosed are benzoheterocyclic alkylamine compounds, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and a preparation method thereof, and use of the same in the manufacture of an antibacterial drug as an inhibitor of staphyloxanthin synthesis in Staphylococcus aureus .

专利号:US-9884842-B2
优先权日:2013-04-19
标题 :Combretastatin analogs
发明人：PENTHALA NARSIMHA REDDY; CROOKS PETER; SONAR VIJAYAKUMAR
权利人:UNIV ARKANSAS; BIOVENTURES LLC
摘要:The present invention relates novel heterocyclic analogs of combretastatin, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I), Formula (II), and Formula (V) are provided.

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人：BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.