CAS: 65156-94-7; 5-Chloro-1H-Pyrrolo[3,2-B]Pyridine

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2231673-54-2 1190310-88-3 1207625-34-0

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CAS号1116138-21-6 5-chloro-1-[(4-... | CAS号123846-69-5 6-氯-3-硝基吡啶乙腈 | CAS号209287-23-0 pyrrolo[3,2-b]p... | CAS号5350-93-6 2-氯-5-氨基吡啶 | CAS号400777-06-2 2-碘-3-氨基-6-氯吡啶 | CAS号4943-67-3 5-甲基-1H-吡咯并[3,2-b]吡啶 | CAS号1000343-73-6 3-溴-5-甲基-4-氮杂吲哚

3-氨基-2-溴-6-氯吡啶置于n-甲基吗啉,Bis-Triphenylphosphine-Palladium(II) Chloride,Copper(L) Iodide,Potassium Tert-Butylate,三乙胺体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 1.0H,反应生成 5-氯-4-氮杂吲哚
参考文献: 6-(Morpholin-4-yl)-Pyridin-2-Yl-1H-Pyrrolo[3,2-B]Pyridine Derivatives As M-Tor Inhibitors[fr] Dérivés De 6-(Morpholin-4-yl)-Pyridin-2-Yl-1H-Pyrrolo[3,2-B]Pyridine En Tant Qu'Inhibiteurs De M-Tor
标题: 6-(Morpholin-4-yl)-Pyridin-2-Yl-1H-Pyrrolo[3,2-B]Pyridine Derivatives As M-Tor Inhibitors[fr] Dérivés De 6-(Morpholin-4-yl)-Pyridin-2-Yl-1H-Pyrrolo[3,2-B]Pyridine En Tant Qu'Inhibiteurs De M-Tor
摘要:该发明涉及式(I)的化合物,其中r1,R2,R3,R4,L和a如描述和索赔中所定义,或其药学上可接受的盐,具有mtor激酶抑制剂活性.该发明还涉及包括式(I)的化合物或其药学上可接受的盐的药物组合物,以及在治疗中使用式(I)的化合物或其药学上可接受的盐,包括治疗需要mtor激酶抑制剂活性的疾病或症状,特别是治疗特发性肺纤维化.

专利信息

专利号:US-2012077802-A1
优先权日:2009-06-10
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-9695191-B2
优先权日:2009-08-05
标题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN
权利人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN; POLYPHOR AG
摘要:Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation modulator b and a spacer moiety c as detailed in the description and the claims. Macrocycles of type (I) are readily manufactured by parallel synthesis or combinatorial chemistry. They are designed to interact with specific biological targets. In particular, they show agonistic or antagonistic activity on the motilin receptor (MR receptor), on the serotonin receptor of subtype 5-HT 2B (5-HT 2B receptor), and on the prostaglandin F2•receptor (FP receptor). They are thus potentially useful for the treatment of hypomotility disorders of the gastrointestinal tract such as diabetic gastroparesis and constipation type irritable bowl syndrome; of CNS related diseases like migraine, schizophrenia, psychosis or depression; of ocular hypertension such as associated with glaucoma and preterm labour.