CAS: 75438-58-3; 6-Chloro-N-(4,5-Dihydro-1H-Imidazol-2-yl)-4-Methoxy-2-Methyl-1H-Pyrimidin-2-Amine,Hydrochloride

上下游产品

5-amino-4-methoxy-6-chloro-2-methyl-pyrimidinemoxonidine

4-氯-6-甲氧基-2-甲基嘧啶-5-胺置于盐酸,Sodium Carbonate,三氯氧磷体系中,用 二甲基亚砜,异丙醇 作为反应溶剂,化学反应 57.0H,反应生成 盐酸莫索尼定
参考文献:Synthesis Of Substituted Aminopyridines
标题:Synthesis Of Substituted Aminopyridines
摘要:本发明涉及一种用于制造具有化学式(i)的某些取代氨基吡啶的新型方法或其互变异构体或盐,其中r1从氢,卤素,C1-4烷氧基,C1-4烷硫基,C1-4烷基,C3-5环烷基中选择,例如r1为卤素如氯;r2为c1-4烷基,例如甲基,乙基,异丙基,正丙基或丁基(任何异构体),例如甲基;r3从氢,C1-4烷氧基,C1-4烷硫基,C1-4烷基,C3-5环烷基中选择,例如c1-4烷基如甲基,乙基,异丙基,正丙基或丁基(任何异构体),例如甲基;以及适用于执行该方法的化学中间体的结晶形式.

专利信息

专利号:WO-2015011010-A1
优先权日:2013-07-26
标 题:Synthesis of substituted aminopyrimidines
发明人：ACQUASALIENTE MAURIZIO; LAGERWEIJ GERT; DESHPANDE MAHENDRA; SHAH RAJENDRA
权利人:ABBOTT HEALTHCARE PRODUCTS BV; ABBOTT LAB
摘要:The present invention relates to a novel process for the manufacture of certain substituted aminopyrimidines having Formula (I) or a tautomer or salt thereof, wherein R 1 is selected from hydrogen, halogen, C 1-4 alkoxy, C 1-4 alklthio, C 1-4 alkyl, C 3-5 cycloalkyl, for example R1 is halogen such as chloro; R2 is C 1-4 alkyl, for example methyl, ethyl, i-propyl, n-propyl or butyl (any isomer), such as methyl; and R3 is selected from hydrogen, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkyl, C 3-5 cycloalkyl, for example C 1-4 alkyl such as methyl, ethyl, i-propyl, n-propyl or butyl (any isomer), for example methyl; crystalline forms thereof as well as chemical intermediates suitable for use in performing the process.

专利号:EP-2829540-A1
优先权日:2013-07-26
标 题 :Synthesis of substituted aminopyridines