CAS: 7635-54-3; (1S,2R,5S)-2-Isopropyl-5-Methylcyclohexyl Carbonochloridate

英文名称(1S,2R,5S)-2-Isopropyl-5-Methylcyclohexyl Carbonochloridate
中文名称(+)-氯甲酸薄荷醇酯
IUPAC名称(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl carbonochloridate
CAS编号7635-54-3
MFCD编号:MFCD00134483
EINECS号:616-327-2
分子式:C11H19ClO2
分子量:218.72
产品CID: 1755670
产品分类化学试剂 → 有机试剂 → 酯类

相似结构搜索
产品信息参考;;;;
InChIKey: KIUPCUCGVCGPPA-AEJSXWLSSA-N
InChI=1S/C11H19ClO2/c1-7(2)9-5-4-8(3)6-10(9)14-11(12)13/h7-10H,4-6H2,1-3H3/t8-,9+,10-/m0/s1…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数3.0

物理性质

沸点108-109 °C11 mm Hg(文献)
闪点158 °F
密度1.031 g/mL at 25 °C(文献)
PSA:26.3
LogP:3.8226
折射率n 20/D 1.458(文献)
蒸汽压0.0546 mmHg at 25 °C
溶解性Soluble In Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,Etc.
外观形态无色至几乎无色透明液体
储存条件2-8°C
产品应用该化合物用作四碳中心不对称合成的奇拉拉添加剂

MSDS等安全信息

GHS象形图
GHS符号GHS06 & GHS05;
注释: Skull and crossbones & Corrosion
危险类别急性毒性类别3(吸入)
皮肤腐蚀类别1B
金属腐蚀物类别1
急性毒性类别2(吸入)
急性毒性类别2(经皮)
急性毒性类别2(经口)
严重眼损伤类别1
警示词Danger(危险)
危险描述H331 |吸入会中毒.
H314 |造成严重皮肤灼伤和眼损伤.
H290 |可能对金属造成腐蚀.
H330 |吸入致命.
H310 |皮肤接触致命.
H300 |吞咽致命.
H318 |造成严重眼损伤.
防范说明P261-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
危险等级6.1(a)
UN编号UN 3277 6.1/PG 2
危险品标志T,C
包装等级II
安全声明26-36/37/39-45-25
危险类别码23-34-20/21/22
WGK Germany3

欧盟法规

C&L通报REACH预注册

上下游产品

phosgene (1S,2R,5S)-(+)-menthol bis(trichloromethyl) carbonate (-)-menthol 1-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxycarbonyl)-4-methoxy-3-triisopropylsilanyl-pyridinium; chloride di-(+)-menthyl diazane-1,2-dicarboxylate

合成工艺路线路线简述

C11H20O3置于氯化亚砜体系中,用二氯甲烷,N,N-二甲基甲酰胺作为反应溶剂,化学反应 12.0H,反应生成 (+)-氯甲酸薄荷醇酯
参考文献:铜催化末端炔烃的区域选择性碘甲酰化获得多功能亲电子试剂 (E)-β-Iodo-α,β-不饱和醛
标题:铜催化末端炔烃的区域选择性碘甲酰化获得多功能亲电子试剂 (E)-β-Iodo-α,β-不饱和醛
摘要:在此,我们描述了一种通过末端炔烃与 Tmscf 3和 Nai的碘甲酰化合成 (E)-β-碘-α,β-不饱和醛的方法.这种合成方法使用廉价且易于处理的化学原料,并采用市售的 Cui 催化剂.它可以将多种末端炔烃转化为具有优异化学选择性,区域选择性和立体选择性的双亲电子(E)-β-碘-α,β-不饱和醛.此外,证明该协议具有丰富的有机反应性.
DOI:10.1021/acs.Orglett.2C02838

海关参考信息

2905122000-异丙醇
2912110000-甲醛
2915110000-甲酸
2903110000-一氯甲烷及氯乙烷
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8304540-B2
优先权日:2007-05-18
标题:Process for stereoselective synthesis of lamivudine
发明人：LI JINLIANG; LV FENG
权利人:LI JINLIANG; LV FENG; SHANGHAI DESANO PHARMACEUTICAL HOLDING CO LTD
摘要:The present invention discloses a process for stereoselective synthesis of Lamivudine comprising the following steps: (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and (b) deprotecting the intermediate of formula (II) to obtain Lamivudine.

专利号:US-10544177-B2
优先权日:2016-12-06
标题:Chiral dihydrobenzooxaphosphole ligands and synthesis thereof
发明人：DESROSIERS JEAN-NICOLAS; FANDRICK DANIEL ROBERT; HADDAD NIZAR; LI GUISHENG; PATEL NITINCHANDRA D; QU BO; RODRIGUEZ SONIA; SENANAYAKE CHRIS HUGH; SIEBER JOSHUA DANIEL; TAN ZHULIN; WANG XIAO-JUN; YEE NATHAN K; ZHANG LI; ZHANG YONGDA
权利人:BOEHRINGER INGELHEIM INT
摘要:This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.

专利号:US-2010063283-A1
优先权日:2007-05-18
标题 :Process for stereoselective synthesis of lamivudine

专利号:US-2010249409-A2
优先权日:2007-05-18
标题 :Process for stereoselective synthesis of lamivudine

专利号:US-2011118465-A2
优先权日:2007-05-18
标题:Process for stereoselective synthesis of lamivudine

专利号:EP-2161267-B1
优先权日:2007-05-18
标题:A process for stereoselective synthesis of lamivudine