CAS: 102-36-3; Isocyanic Acid 3,4-Dichlorophenyl Ester

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CAS号32315-10-9 三光气 | CAS号95-76-1 3,4-二氯苯胺 | CAS号6112-01-2 3,4-dichloroben... | CAS号75-44-5 光气 | CAS号7159-94-6 3, 4-二氯苯基氨基甲酸乙酯 | CAS号1918-18-9 灭草灵 | CAS号99-54-7 1,2-二氯-4-硝基苯 | CAS号201230-82-2 carbon monoxide | CAS号3024-72-4 3,4-二氯苯甲酰氯 | CAS号51-44-5 3,4-二氯苯甲酸 | CAS号108176-69-8 1-(2H-1,4-benzo... | CAS号3567-62-2 N-(3,4-二氯苯基)-N-甲基尿素 | CAS号330-54-1 敌草隆 | CAS号330-55-2 利谷隆 | CAS号28478-77-5 N-(3,4-dichloro... | CAS号95-76-1 3,4-二氯苯胺 | CAS号6590-94-9 3,4-二氯异硫氰酸苯酯 | CAS号7159-94-6 3, 4-二氯苯基氨基甲酸乙酯 | CAS号13208-22-5 N-(3,4-Dichloro...

灭草灵置于三氯化硼,三乙胺体系中,用 苯 用作溶剂,化学反应 0.5H,以87%的收率获得3,4-二氯苯异氰酸酯
参考文献:Synthesis Of Isocyanates From Carbamate Esters Employing Boron Trichloride
标题:Synthesis Of Isocyanates From Carbamate Esters Employing Boron Trichloride
摘要:在有 Et3N 存在的情况下,使用 Bcl3 可以将氨基甲酸酯转化为具有工业重要性的异氰酸酯和二异氰酸酯;该反应的实施和操作简单,在温和的条件下进行,并能以极高的收率获得异氰酸酯.
Doi:10.1039/a807287F

专利信息

专利号:US-4267070-A
优先权日:1979-10-30
标题:Catalyst for the synthesis of aromatic monoisocyanates
发明人：NEFEDOV BORIS K; MANOV-JUVENSKY VLADIMIR I; DERGUNOV JURY I; RYSIKHIN ANATOLY I; CHIMISHKIAN ALEXANDR L
权利人:NEFEDOV BORIS K; MANOV JUVENSKY VLADIMIR I; DERGUNOV JURY I; RYSIKHIN ANATOLY I; CHIMISHKIAN ALEXANDR L
摘要:A catalyst for the synthesis of aromatic monoisocyanates comprising 1.64 to 16.6% by weight of palladium chloride, 0.16 to 47.6% by weight of an oxide of a metal of Group VB of the periodic system, 1.5 to 81.8% by weight of an oxide of a metal of Group VI B of the periodic system, 1.64 to 89.8% by weight of pyridine or an alkylsubstituted pyridine. n The use of the catalyst according to the invention in the synthesis of aromatic monoisocyanates makes it possible to obtain a high degree of conversion of the starting compound of up to 100%, a high yield of the desired product of up to 97%, and increased productivity of the catalyst of up to 40 g of the desired product per g of PdCl 2 per hour.

专利号:US-4921997-A
优先权日:1988-06-15
标题 :Method of synthesis and novel compounds for pharmaceutical uses
发明人：LALEZARI IRAJ; LALEZARI PARVIZ
权利人:MONTEFIORE MED CENTER
摘要:The present invention is concerned with a process for the synthesis of substituted arylureidophenexymethyl propionic acids and an analogous benzamides series of compounds which have activity in the dissociation of oxygen from hemoglobin. In addition, the process may be utilized to prepare compounds which are known.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-3213121-A
优先权日:1959-06-22
标题 :Synthesis of 3-aryl-1 methyl-1-methoxy ureas
发明人：SMATHERS DONALD L
权利人:DU PONT

专利号:US-6054464-A
优先权日:1996-02-23
标题:Azabicyclic esters of carbamic acids useful in therapy
发明人：MACOR JOHN; WU EDWIN
权利人:ASTRA AB
摘要:A compound of formula ##STR1## X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C--R 4 ; R 1 is hydrogen or methyl; R 2 is hydrogen or fluoro; R 3 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5 , --CN, --CONH 2 , --CO 2 R 5 , --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; R 4 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5 , --CN, --CONH 2 , --CO 2 R 5 , --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; n or R 2 and R 3 or R 3 and R 4 may together represent a fused phenyl ring optionally substituted with one or two of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; R 5 and R 6 are independently hydrogen or C 1 to C 3 alkyl; n or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing the, compositions containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders, as well as intermediates and use of intermediates in synthesis.