6,6-二甲基-2-亚甲基二环[3.1.1]-3-庚醇置于lithium Aluminium Tetrahydride,氧气,亚甲兰,四氯化钛体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 38.0H,反应生成Beta-蒎烯 参考文献:A New Synthesis Of (-)-β-Pinene From (-)-α-Pinene 标题:A New Synthesis Of (-)-β-Pinene From (-)-α-Pinene 摘要: Doi:10.1055/s-1982-29984
专利号:WO-2024012791-A1 优先权日:2022-07-11 标题 :Electrochemical synthesis of pyrazolines and pyrazoles 发明人:BÄR ROBIN MAXIMILIAN; FORD MARK JAMES; KALDAS SHERIF JAMES; WALDVOGEL SIEGFRIED; HOFMANN SILJA; LINDEN MARTIN 权利人:BAYER AG 摘要:The present invention relates to an electrochemical process for the synthesis of pyrazolines and pyrazoles of formula (I). The process can be especially used for the synthesis of the herbicide safener mefenpyr-diethyl.
专利号:US-11046978-B2 优先权日:2016-03-16 标 题:Synthesis of isoprenoids and derivatives 发明人:GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG 权利人:UNIV RICE WILLIAM M 摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.
专利号:US-4140708-A 优先权日:1975-10-16 标 题 :Asymmetric synthesis of optically active prostaglandins 发明人:CHADHA NARESH K; PARTRIDGE JR JOHN J; USKOKOVIC MILAN R 权利人:HOFFMANN LA ROCHE 摘要:An asymmetric synthesis of optically active prostaglandin F 2 α from cyclopentadiene including intermediates in this synthesis.
专利号:US-3933892-A 优先权日:1973-02-12 标题 :Asymmetric synthesis of optically active prostaglandins 发明人:CHADHA NARESH KUMAR; PARTRIDGE JR JOHN JOSEPH; USKOKOVIC MILAN RADOJE 权利人:HOFFMANN LA ROCHE 摘要:An asymmetric synthesis of optically active prostaglandin F 2 .sub.α from cyclopentadiene including intermediates in this synthesis.
专利号:US-7429658-B2 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines 发明人:HOWARD PHILIP; MASTERSON LUKE 权利人:SPIROGEN LTD 摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):
专利号:US-4727146-A 优先权日:1980-07-03 标题 :Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction 发明人:RICE KENNER C 权利人:US HEALTH 摘要:In a short total synthesis of morphinan compounds, derivatives of 1-benzyl-1,2,3,4-tetrahydroisoquinoline are produced. Certain of these compounds, although highly aromatic and functionalized, can be optically resolved. The optically active enantiomers can serve as important intermediates for both natural and unnatural opioids. As a special function of this invention, certain of the derivatives, namely 4'-6' and 7'-9', may be hydrogenated to 1'-3' derivative by asymmetric reduction either of the catalytic or chemical type.
摘要:Zaidlewicz, M.; Krzemiński, M. P.; Dzieleńdziak, A., Science of Synthesis, (2009) 48, 380. 摘要:Lam, K.; Leech, M. C.; Lennox, A. J. J., Science of Synthesis: Special Topics, (2021) 1, 462. 参考文献:10.1006/abbi.1999.1467 摘要:Phillips MA, Savage TJ, Croteau R. Monoterpene Synthases of Loblolly Pine (Pinus taeda) Produce Pinene Isomers and Enantiomers. Archives of Biochemistry and Biophysics. 1999 Dec;372(1):197–204. doi: 10.1006/abbi.1999.1467. 参考文献:10.1142/s0192415x0400193x 摘要:Lai EY, Chyau CC, Mau JL, Chen CC, Lai YJ, Shih CF, Lin LL. Antimicrobial activity and cytotoxicity of the essential oil of Curcuma zedoaria. Am J Chin Med. 2004;32(2):281–90. doi: 10.1142/s0192415x0400193x.