CAS: 138687-69-1; Perfluorophenyl Diphenylphosphinate

上下游产品

2,3,4,5,6-pentafluorophenol Diphenylphosphinic chloride

五氟苯酚,二苯基次膦酰氯置于咪唑体系中,用 二氯甲烷 用作溶剂,以92%的收率获得五氟苯基二苯基磷酸酯
参考文献:二肽合成中偶联试剂选择的比较研究
标题:二肽合成中偶联试剂选择的比较研究
摘要:摘要 对所选偶联试剂在二肽合成中的有效性进行了比较研究.研究中包括一种新的偶联试剂,五氟苯基二苯基次膦酸盐 (Fdpp,1),苯并三唑-1-基-氧基三(二甲氨基) 六氟磷酸鏻(Bop,2),2-(1H-苯并三唑-1-基)-1,1,3,3-四甲基六氟磷酸盐 (Hbtu,3) 和氯甲酸异丁酯 (Ibcf,4).我们发现 Bop (2) 提供了最高的收率和最低的外消旋化限制.
Doi:10.1080/00397919308009787

专利信息

专利号:US-11274081-B2
优先权日:2016-05-30
标 题:Process for the synthesis of ivacaftor
发明人：REDDY DUMBALA SRINIVASA; KULKARNI AMOL ARVIND; NATARAJAN VASUDEVAN; SHARMA MRITYUNJAY KESHAVPRASAD
权利人:COUNCIL SCIENT IND RES
摘要:The present disclosed an improved process for the synthesis of ivacaftor starting from indole acetic acid ester which can be performed in batch as well as continuous flow synthesis. The present invention further disclosed to a continuous process for the synthesis of compound of formula (II) or formula (III) from compound of formula (I) in continuous flow reactor.

专利号:US-10336703-B2
优先权日:2015-05-12
标题 :Process for the synthesis of ivacaftor and related compounds
发明人：REDDY DUMBALA SRINIVASA; NATARAJAN VASUDEVAN; JACHAK GORAKHNATH RAJARAM
权利人:COUNCIL SCIENT IND RES
摘要:The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and Ar 1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.

专利号:WO-2025088147-A1
优先权日:2023-10-27
标题 :Theranostic psma-targeting ligands for the diagnosis and treatment of psma-expressing cancers and their solid phase synthesis
发明人：Schäfer Martin; BAUDER-WUEST ULRIKE; ROSCHER MAREIKE; REMDE YVONNE; BENEÅ OVÃ?-SCHÄFER MARTINA; BARINKA CYRIL; KUTILOVÃ? ZSÓFIA; MOTLOVÃ? LUCIA
权利人:DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS
摘要:The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and radiopharmaceuticals for the treatment of various disease states of PSMA-expressing cancers, especially prostate cancer, and metastases thereof. Further the present invention provides synthetic procedures for the synthesis of such PSMA-targeting ligands.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-2025002505-A1
优先权日:2021-10-05
标题 :Synthesis of macroyclic compounds
发明人：PAL BIMAN; LIU JING; MARTIN KEVIN; ZHANG HAN
权利人:TURNING POINT THERAPEUTICS INC
摘要:The present disclosure provides new methods of preparing a compound of Formula (I). Such methods can prepare the compound at any scale, including gram and kilogram scale.

专利号:WO-2022127920-A1
优先权日:2020-12-18
标 题:Preparation method for and intermediate of 5'-nucleoside prodrug
发明人：SHEN JINGSHAN; HU TIANWEN; XIE YUANCHAO; ZHU FUQIANG
权利人:TOPHARMAN SHANGHAI CO LTD
摘要:Provided in the present invention are a preparation method for and an intermediate of a 5'-nucleoside prodrug. Specifically, provided in the present invention is a method for preparing a compound of formula VI. The method comprises the steps of: (a) reacting a compound of formula I and a compound of formula II to obtain a compound of formula III; (b) reacting the compound of formula III and reagent M to obtain a compound of formula IV; (c) reacting the compound of formula IV in the presence of reagent N to obtain a compound of formula V; and (d) reacting the compound of formula V with reagent O to obtain a compound of formula VI. The preparation method provided by the present invention has the advantages of having low costs, high yield, good product purity and the like, and is capable of achieving the efficient synthesis of 5'-nucleoside prodrugs.