CAS: 3386-18-3; 3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-Diol

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CAS号105891-55-2 2-[2-[2-[2-[2-[... | CAS号246832-16-6 1,1,1,30,30,30-... | CAS号112-27-6 三甘醇 | CAS号669556-53-0 Benzyl-PEG9-THP | CAS号55489-58-2 三甘醇单苄醚 | CAS号2615-15-8 六乙二醇 | CAS号84131-04-4 三乙二醇单苄醚对甲苯磺酸酯 | CAS号42607-87-4 THP-PEG6-OH | CAS号103304-45-6 3,6,9,12,15,18,...

三乙二醇置于palladium On Activated Charcoal Sodium Hydroxide,氢气,Sodium Hydride体系中,用 四氢呋喃,乙醇 作为反应溶剂,20.0~100.0 °C,810.6 Kpa 条件下,反应 71.0H,反应生成 九甘醇
参考文献:寡聚(乙二醇)向44聚体的合成
标题:寡聚(乙二醇)向44聚体的合成
摘要:描述了一种低聚(乙二醇)向44聚体(fw = 1956.35)的合成方法.重复威廉姆森的醚合成和氢化以除去保护的苄基,以中等收率向44-聚体提供所需的寡聚(乙二醇).该方法的优点是使用市售易得的材料作为起始材料和方法,从而避免了尽可能多地纯化产物的困难.
DOI:10.1021/jo0617464

专利信息

专利号:WO-2023102600-A1
优先权日:2021-12-06
标题:Synthesis of amphiphilic block copolymers and polymeric nanofibers produced therefrom
发明人：ZETTERLUND PER B; ISHIZUKA FUMI; KIM HYUN JIN; CHATANI SHUNSUKE; NIINO HIROSHI
权利人:NEWSOUTH INNOVATIONS PTY LTD
摘要:The present disclosure relates to the field of synthesis of block copolymers, and polymeric nanofibers having a core-shell morphology produced therefrom. The present disclosure relates to the field of synthesis of block copolymers where one block is more hydrophobic than the other block and is a different composition. The disclosure also relates to uses of these polymeric nanofibers in various applications, such as reinforcing a polymeric matrix and for coatings applications.

专利号:US-2022265691-A1
优先权日:2019-07-12
标 题 :Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types
发明人：MAGNANI JOHN L; FOGLER WILLIAM E; THACKRAY HELEN M; FELDMAN ERIC J; STEWART DAVID
权利人:GLYCOMIMETICS INC
摘要:Cancer patients that express high levels of the E-selectin ligand (sialyl Lea/x) on their tumors have a poorer outcome. Interestingly, relapsed/refractory acute myeloid leukemia (AML) patients expressing high levels of sialyl Lex on their blasts show the greatest therapeutic response when treated with the E-selection inhibitor compound of Formula I. Transcriptome profiling of E-selectin ligand-forming glycosylation genes showed that ST3GAL4 and FUT7 were consistently expressed in the majority of cancers evaluated. Poor survival outcomes of FLT3-mutated AML patients that express high levels of ST3GAL4 and FUT7 implicated E-selectin in this disease state. These genes may be predictive biomarkers in AML patients. Methods of treatment of cancer comprising screening AML patients for expression of genes that contribute to the synthesis of the E-selectin ligand sialyl Lex, then treating those patients with an E-selection inhibitor, are disclosed.

专利号:EP-0021497-A1
优先权日:1979-06-21
标 题 :Synthesis of polyoxyalkylene glycol monoalkyl ethers
发明人：GIBSON THOMAS WILIAM
权利人:PROCTER & GAMBLE
摘要:A solvent free method for preparing monoalkyl ethers of polyoxyalkylene glycols, comprising mixing a polyoxyalkylene glycol, especially polyoxyethylene glycol, with a concentrated aqueous solution of a metal hydroxide, contacting said mixture with a primary alkyl halide, and recovering the monoalkyl ether.

专利号:EP-1406599-B1
优先权日:2001-07-07
标 题 :Cosmetic and dermatological preparations containing creatine for treating and actively preventing dry skin and other negative alterations of the physiological homeostasis of healthy skin
发明人：SAUERMANN GERHARD; SCHREINER VOLKER; DOERING THOMAS; SIEFKEN WILFRIED; GATERMAN CORNELIA; CARSTENSEN STEFANIE; BIERGIESSER HELGA; BLATT THOMAS
权利人:BEIERSDORF AG
摘要:Topical compositions containing creatine and its precursors and derivatives, are used to improve skin condition and to treat or prevent skin disorders, abnormal lipid peroxidation, reduced cell-cell communication, deficient intracellular DNA synthesis, DNA damage, deficient DNA repair, abnormal post-translational modification of connective tissue components and dandruff. Topical compositions comprising creatine and its precursors and derivatives and optionally electrolytes, polyols, urea and osmolytes are used: (1) to treat or prevent dry skin, to enhance the barrier function of the skin, for treatment, care and prophylaxis of sensitive skin and/or for treatment and prophylaxis of symptoms of a negative change in the physiological homeostasis of normal skin; (2) to treat or prevent inflammatory skin conditions, atopic eczema, polymorphic photodermatitis, psoriasis, vitiligo and sensitive, itching or irritated skin; (3) to treat or prevent abnormal lipid peroxidation; (4) to treat or prevent abnormal ceramide, lipid and energy metabolism of the skin, abnormal transepidermal water loss, reduced skin hydration and moisture content and altered Natural Moisturizing Factor content; (5) to treat or prevent reduced cell-cell communication, deficient intracellular DNA synthesis, DNA damage, reduced endogenous DNA repair, activation of metalloproteinases and/or other proteases or inhibition of corresponding DNA repair mechanisms and abnormal post-translational modification of connective tissue components; (6) to treat or prevent abnormal skin hyaluronic acid and glucosaminoglycan content; and (7) to treat or prevent dandruff of the hair and scalp and skin aging.

专利号:US-4561869-A
优先权日:1983-01-19
标题:Cryogenic process for the selective removal of acid gases from gas mixtures by means of a solvent
发明人：GAZZI LUIGI; D AMBRA ROBERTO; DI CINTIO ROBERTO; RESCALLI CARLO; VETERE ALESSANDRO
权利人:SNAM PROGETTI
摘要:A cryogenic process for removing acid gases from natural or synthesis gases, comprising the following stages: n (a) feeding the natural or synthesis gas to a first absorption column in order to absorb the H 2 S; n (b) cooling the substantially H 2 S-free gas to condense part of the CO 2 contained in said gas; n (c) feeding the cooled and partly condensed gas to a second absorption column in order to reduce the CO 2 content to the required value; n (d) regenerating the solvent or solvents used in the acid gas absorption, the solvent or solvents used being chosen from esters, alcohols or ethers, of low molecular weight.

专利号:US-2018312534-A1
优先权日:2015-10-16
标题:Fluorescent anticancer platinum drugs
发明人：SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA
权利人:INVICTUS ONCOLOGY PVT LTD
摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.