CAS: 349-65-5; 2-Methoxy-5-(Trifluoromethyl)Aniline

上下游产品

CAS号394-25-2 4-甲氧基-3-硝基三氟甲苯 | CAS号7439-89-6 铁粉 | CAS号402-10-8 2-溴-1-甲氧基-4-(三氟甲基)苯 | CAS号352-32-9 对氟甲苯 | CAS号367-86-2 3-硝基-4-氟三氟甲苯 | CAS号402-44-8 4-氟三氟甲苯 | CAS号402-42-6 4-氟三氯苄 | CAS号402-10-8 2-溴-1-甲氧基-4-(三氟甲基)苯 | CAS号75919-92-5 4-乙酰-4-硝基联苯醚 | CAS号16588-75-3 2-甲氧基-5-三氟甲基苯异氰酸酯 | CAS号174654-98-9 6-[[2-methoxy-5...

对氟甲苯置于盐酸,氢氧化钾,Tin,五氯化磷,硫酸,氢氟酸,硝酸体系中,化学反应生成2-甲氧基-5-三氟甲基苯胺
参考文献:Brown Et Al.,Journal Of The Chemical Society,1949,P. Spl. 113
标题:Brown Et Al.,Journal Of The Chemical Society,1949,P. Spl. 113

专利信息

专利号:US-2009253913-A1
优先权日:2008-03-06
标题:Process for the preparation of sorafenib and salts thereof
发明人：ROSSETTO PIERLUIGI; MACDONALD PETER LINDSAY; CANAVESI AUGUSTO
权利人:ROSSETTO PIERLUIGI; MACDONALD PETER LINDSAY; CANAVESI AUGUSTO
摘要:Methods for the synthesis of the N-carbamoyl imidazole (I) and its 1:1 adduct with imidazole are provided. Methods for the preparation of these crystalline intermediates in a high state of purity are also provided. These intermediates react cleanly under mild conditions to produce sorafenib in high yield and purity, without generating difficult-to-remove impurities.

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.