CAS: 3970-37-4; 1-Bromo-2-Chloro-3-Nitrobenzene

上下游产品

CAS号3970-35-2 2-氯-3-硝基苯甲酸 | CAS号59255-95-7 2-溴-6-硝基苯胺 | CAS号3970-41-0 2-氯-3-硝基苯胺 | CAS号26429-41-4 1,2-二溴-3-硝基苯 | CAS号583-53-9 1,2-二溴苯 | CAS号32337-96-5 3-溴-2-碘硝基苯 | CAS号58534-94-4 2-氟-3-溴硝基苯 | CAS号98775-19-0 1-溴-2-甲氧基-3-硝基苯

4-氯-3-硝基苯磺酸置于n-溴代丁二酰亚胺(Nbs),硫酸体系中,化学反应 9.0H,反应生成1-溴-2-氯-3-硝基苯
参考文献:一种2-氯-3-溴苯胺的制备方法
标题:一种2-氯-3-溴苯胺的制备方法
摘要:本发明公开了一种2‑氯‑3‑溴苯胺的制备方法,所述制备方法的具体步骤为:(1)化合物ii与溴代丁二酰亚胺发生亲电取代反应,生成化合物iii;(2)将化合物iii的磺酸基脱除,生成化合物iv;(3)采用保险粉将化合物iv还原成化合物i,即所述2‑氯‑3‑溴苯胺.本发明以4‑氯‑3‑硝基苯磺酸为起始原料的全合成路线过程中避免了大量毒性大,污染大的试剂,同时原料价格低廉,产率更高.

专利信息

专利号:US-6069149-A
优先权日:1997-01-09
标 题:Amide derivatives and intermediates for the synthesis thereof
发明人：NANBA RYOUICHI; IIZUKA TAKAO; ISHII TAKEO
权利人:TERUMO CORP
摘要:PCT No. PCT/JP98/00005 Sec. 371 Date Nov. 23, 1998 Sec. 102(e) Date Nov. 23, 1998 PCT Filed Jan. 6, 1998 PCT Pub. No. WO98/30562 PCT Pub. Date Jul. 16, 1998Novel compounds which are amide derivatives represented by general formula (I) and medicinal preparations containing the same having an eosinophilic infiltration inhibitory effect based on a potent interferon ( alpha , gamma )-inducing activity and an exellent percutaneous absorbability and being efficacious in treating allergic inflammatory diseases such as atopic dermatitis, various tumors and viral diseases. In said formula, each symbol has the following meaning: R1 and R2: each lower alkyl, etc.; X and Y: independently representing each oxygen, NR4, CR5 etc. (wherein R4 and R5 independently represent each hydrogen, an aromatic group, etc.); Z: an aromatic ring or heterocycle; R3: hydrogen, lower alkoxy, etc.; g, i and k: independently representing each an integer of from 0 to 6; h, i and l: independently representing each an integer of 0 or 1; m: an integer of from 0 to 5; and n: an integer of from 2 to 12.

专利号:US-2008280933-A1
优先权日:2006-07-25
标 题:Benzimidazolyl compounds
发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
权利人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-10858359-B2
优先权日:2016-06-07
标题 :Heterocyclic ring derivatives useful as SHP2 inhibitors
发明人：MA CUNBO; GAO PANLIANG; CHU JIE; WU XINPING; WEN CHUNWEI; KANG DI; BAI JINLONG; PEI XIAOYAN
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.