CAS: 591-12-8; 5-Methylfuran-2(3H)-One

相似化合物

591-12-8 83056-58-0 20825-71-2

上下游产品

5-methyl-5H-furan-2-one prop-2-yn-1-ylpropanedioic acid 4-pentynoic acid zinc(II) carbonate levulinic acid methyl ester 4-oxopentanoic acid ethyl ester 4,5-Dihydro-5-methoxy-5-methylfuran-2(3H)-one H-furan-2-one3-((Ξ)-4-amino-benzylidene)-5-methyl-3H-furan-2-one

乙酰丙酸置于二氯二茂钛,氢气,异丙基氯化镁体系中,用 四氢呋喃 作为反应溶剂,100.0 °C,689.49 Kpa 条件下,反应 24.0H,以5%的收率获得产物当归内酯
参考文献:在温和条件下使用均相钛催化剂将乙酰丙酸氢化成 γ-戊内酯
标题:在温和条件下使用均相钛催化剂将乙酰丙酸氢化成 γ-戊内酯
摘要:使用市售的二茂钛络合物 [cp 2 Ticl 2] 开发了一种钛基催化体系,用于将乙酰丙酸氢化成 γ-戊内酯 (Gvl),使用温和的反应条件(100 oc 和 100 Psi)和优异的产率(>99%).还记录了关键的机理见解,包括催化循环中涉及的主要物种.
DOI:10.1016/j.Jcat.2022.08.013

专利信息

专利号:US-3992413-A
优先权日:1975-07-25
标 题 :Intermediates in the synthesis of prostaglandins
发明人：TAUB DAVID; WENDLER NORMAN L
权利人:MERCK & CO INC
摘要:The invention relates to a new and novel synthesis of prostaglandin E 2 , and it particularly relates to a novel process starting with relatively inexpensive starting materials. The invention further relates to a synthesis which is readily adaptable for large scale processing because of the high yields in the individual reaction steps. n The invention further relates to novel compounds formed as intermediates in the synthesis of prostaglandin E 2 . The invention still further relates to synthetic analogs and known metabolites of prostaglandin E 2 and prostaglandin E 1 , useful as standards in certain biological assays for determining prostaglandin-like activity.

专利号:US-5831103-A
优先权日:1992-10-20
标 题:Halogen-magnesium-aluminum hydridohalides, methods for their synthesis and their use as reducing agents
发明人：KNOTT WILFRIED
权利人:GOLDSCHMIDT AG TH
摘要:Halogen magnesium aluminum hydridohalides of the general formula[Mg2X3(ether)y]+[AlH4-nXn]-wherein X is chlorine, bromine or iodine, y is a number from 0 to 6, n is a number from 1 to 3 and ether is an aliphatic or cylcoaliphatic ether with 2 to 30 carbon atoms, with the exception of t-butyl ether, with a dipole moment>0.5 Debye and a melting point of<0 DEG C. are prepared. The invention furthermore relates to a method for the synthesis of these compounds and to a method of reducing functional organic compounds utilizing the inventive compounds.

专利号:US-2024425890-A1
优先权日:2022-02-11
标 题:Process for the synthesis of alpha-methylene-gamma-butyrolactone
发明人：TADEN ANDREAS; BECK HORST; MYRTOLLARI KAMELA; KOURIST ROBERT; NIGL ANDREA
权利人:HENKEL AG & CO KGAA
摘要:The present application provides a process for the preparation of α-methylene-γ-butyrolactone, said process comprising the steps of:a) acetylating the C1-hydroxyl group of isoprenol to yield isoprenyl acetate;b) forming 4-acetoxy-2-methylene-butan-1-ol from said isoprenyl acetate by whole cell biotransformation, said step comprising:i) contacting a cell (CB) with a culture medium containing said isoprenyl acetate or with a culture medium contiguous with an organic phase containing said isoprenyl acetate under conditions that enable the cell to form 4-acetoxy-2-methylene-butan-1-ol from isoprenyl acetate; and,ii) optionally isolating the resultant 4-acetoxy-2-methylene-butan-1-ol, wherein said cell (CB) exhibits activity of at least one alkane monooxygenase enzyme which catalyzes the formation of 4-acetoxy-2-methylene-butan-1-ol from isoprenyl acetate;c) oxidizing said 4-acetoxy-2-methylene-butan-1-ol to yield 4-acetoxy-2-methylene butyric acid; and,d) converting said 4-acetoxy-2-methylene butyric acid to α-methylene-γ-butyrolactone by hydroxylysis to γ-hydroxy-α-methylenebutyric acid and subsequent cyclization of said γ-hydroxy-α-methylenebutyric acid.

专利号:US-2012283493-A1
优先权日:2009-06-05
标题:Multiproduct biorefinery for synthesis of fuel components and chemicals from lignocellulosics via levulinate condensations
发明人：OLSON EDWIN S; HEIDE CARSTEN
权利人:OLSON EDWIN S; HEIDE CARSTEN
摘要:An integrated method for production of fuels, fuel additives, or chemicals in a biorefinery by the conversion of cellulosic materials is disclosed herein. The method is based on converting a source of C6 sugar into a mixture of hydrotreated compounds. Embodiments of the method can be highly integrated, with reagents for particular steps being provided by other steps of the process.

专利号:US-7579294-B2
优先权日:2004-12-29
标题:Synthesis of supported transition metal catalysts
发明人：PARK JAIWOOK; KIM NAMDU; KWON MIN SERK; PARK CHEON MIN
权利人:POSTECH FOUNDATION
摘要:A highly active and recyclable supported transition metal catalyst can be prepared by a simple process comprising mixing with heating a transition metal complex, a metal-chelating agent and an alkoxide of Ti, Al or Si, followed by treatment with water to induce a sol-gel reaction among the reactants.

专利号:US-7030230-B2
优先权日:2002-10-25
标题:Process of purifying phosphoramidites
发明人：ROSS BRUCE; SONG QUANLAI
权利人:ISIS PHARMACEUTICALS INC
摘要:A process of purifying phosphoramidite precursors useful in inter alia synthesis of oligonucleotides comprises dissolving a crude phosphoramidite in a polar phase, adding a basic compound to the polar phase, adding a portion of water to the polar phase, contacting the polar phase with a first apolar phase to extract impurity into the apolar phase, separating the first apolar phase from the polar phase, adding a second aliquot of water to the polar phase, and contacting the polar phase with a second apolar phase, whereby the phosphoramidite partitions into the second apolar phase.