CAS: 6270-16-2; 3-Nitrobutan-2-Ol

相似化合物

960008-54-2 42551-55-3 110716-81-9

上下游产品

CAS号77-49-6 2-硝基-2-甲基-1,3-丙二醇 | CAS号123-38-6 丙醛 | CAS号108-03-2 1-硝基丙烷 | CAS号79-24-3 硝基乙烷 | CAS号75-07-0 乙醛 | CAS号64-17-5 乙醇 | CAS号107-01-7 2-丁烯 | CAS号60-29-7 乙醚 | CAS号10544-72-6 四氧化二氮 | CAS号79-24-3 硝基乙烷 | CAS号75-07-0 乙醛

硝基乙烷置于水,氧气,1,10-Ethylidene-7,8-Dimethoxy-3-Methylisoalloxazinium Chloride,三乙胺体系中,25.0 °C,455.99 Kpa 条件下,以62 %的收率获得产物3-硝基-2-丁醇
参考文献:催化人工硝基烷氧化酶--一种实现有机催化 Umpolung 的方法
标题:催化人工硝基烷氧化酶--一种实现有机催化 Umpolung 的方法
摘要:硝基烷氧化酶 (Nao) 是一种黄素酶,可催化硝基烷氧化成相应的羰基化合物,同时产生亚硝酸根阴离子.在此,我们提出了一种使用黄素或乙烯桥联黄素盐的人工催化系统,该系统通过类似 Nao 的过程起作用.在溶剂,碱,温度和氧气压力方面优化的条件下,伯硝基烷烃被转化为醛.在我们的系统中,醛立即与其他硝基烷分子反应形成 β-硝基醇.还原的黄素催化剂被氧气再氧化.β-硝基醇的替代机制通过5-(2-硝基丁基)-1,5-二氢黄素是通过量子化学计算以及通过捕获和表征这种二氢黄素中间体提出的.有趣的是,5-(2-硝基丁基)-1,5-二氢黄素是先前在 Nao X 射线结构中观测到的黄素腺嘌呤二核苷酸加合物的类似物.在这两种机制途径中,Flavin-5-Iminium 物质是通过硝基烷化物与黄素的加成形成的.这个过程代表基于黄素的原始供体到受体的 Umpolung.
DOI:10.1039/d3Ob00101F

专利信息

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:AU-599215-B2
优先权日:1983-05-17
标 题 :A novel chemical intermediate of the synthesis of aromatic biocidal compounds

专利号:US-9861636-B2
优先权日:2014-04-29
标题 :Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
发明人：HE WEI
权利人:HE WEI; ZHEJIANG DTRM BIOPHARMA CO LTD
摘要:Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.