CAS: 62803-47-8; 6-Hydroxy-2,3-Dihydro-1H-Inden-1-One

该化合物是一个有机化合物,其特征为异丹酮结构,其特点是与一个氢氧基化合物组相邻,其功能组群具有一个可使用克酮的功能组群,该化合物一般在室温时是固体,在有机溶剂中可溶解.其分子结构包括一个六人组成的芳香环环,该环环环体结合了五人组成,有助于其独特的化学特性.该环体组的存在具有氢联结的潜力,影响其再活性和溶性. 6-Hydroxyindan-1-one可能展示生物活动,使其对药用化学和研究感兴趣.其衍生物可以合成各种用途,包括药品和农用化学剂.该化合物的稳定性和再活性可能受到诸如pH和温度等因素的影响,并可能经历典型的有机反应,包括氧化和替代.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

6-甲氧基-1-茚酮 6-Methoxy-2,3-Dihydro-1H-Inden-1-One 13623-25-1
1-茚酮 1-Indanone 83-33-0
6-氨基-1-茚酮 6-Aminoindan-1-One 69975-65-1

合成工艺路线路线简述

    4-甲氧基肉桂酸置于aluminum (Iii) Chloride,氯化亚砜,镍,一水合肼,氢化铝,Sodium Hydroxide体系中,用 甲苯 作为反应溶剂,化学反应生成 6-羟基-1-茚酮
    参考文献:Bipolar Carrier Transport In Tri-Substituted octyloxy-Truxene Dlc
    标题:Bipolar Carrier Transport In Tri-Substituted octyloxy-Truxene Dlc
    摘要:In This Study,Bipolar Charge Carrier Transport Of 2,7,12-Trioctyloxytruxene Has Been Studied By A Time-Of-Flight Method. The Substance Studied Exhibits A Hexagonal Columnar Mesophase Of Which Melting And Clearing Points Are 118 Degrees C And 133 Degrees C,Respectively. Ambipolar Electronic Carrier Transports Were Observed In The Mesophase. The Drift Mobility Measurements Reveal It Is In The Order Of 10(-2) Cm(2) V-1 S(-1) In The Col(H) And It Increases To 10(-1) Cm 2 V-1 S(-1) At The Columnar Mesophase-Metastable Phase Transition,Indicating Truxene Is An Interesting Molecular Core For Mesophase Semiconductors.
    DOI:10.1080/15421406.2011.568891

    海关参考信息

    专利信息


    专利号:US-7476757-B2
    优先权日:2005-02-22
    标 题:Process for the synthesis of enantiomeric indanylamine derivatives
    发明人:BOULTON LEE TERENCE; LENNON IAN CAMPBELL; BAHAR ELIEZER
    权利人:TEVA PHARMA
    摘要:A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)-propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or pressure hydrogenation in the presenc of an optically active catalyst to reduce 1-indanones. The chiral product, either (S)- or (R)-indanols undergo nucleophilic substitution to produce the named product. In an additional aspect, the invention relates to novel intermediates and compounds, namely, substituted indanones, substituted (S)-indanols and substituted (R)-indanols.

    专利号:US-2006199974-A1
    优先权日:2005-02-22
    标 题:Process for the synthesis of enantiomeric indanylamine derivatives

    专利号:US-2008200720-A1
    优先权日:2005-02-22
    标题:Process for the synthesis of enantiomeric indanylamine derivatives

    专利号:US-7375249-B2
    优先权日:2005-02-22
    标 题:Process for the synthesis of enantiomeric indanylamine derivatives

    专利号:US-8580822-B2
    优先权日:2006-12-11
    标 题:Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
    发明人:BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD
    权利人:BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD; REVIVA PHARMACEUTICALS INC
    摘要:The present invention provides novel indanone derivatives which can be advantageously used for treating and/or preventing of a medical condition for which inhibition of a cholinesterase is desired.

    专利号:AU-2006245349-A1
    优先权日:2005-02-22
    标题:Improved process for the synthesis of enantiomeric indanylamine derivatives
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    主要参考文献

    参考标题:Synthesis Of A Novel Series Of Tricyclic Indan Derivatives As Melatonin Receptor Agonists
    作者:Osamu Uchikawa,Kohji Fukatsu,Ryosuke Tokunoh,Mitsuru Kawada,Kiyoharu Matsumoto,Yumi Imai,Shuji Hinuma,Koki Kato,Hisao Nishikawa,Keisuke Hirai,Masaomi Miyamoto,Shigenori Ohkawa |发布日期:2002.9.1
    摘要:6-Position Incorporated Into A Furan, 1,3-Dioxane, Oxazole, Pyran, Morpholine, Or 1,4-Dioxane Ring System. Among These Compounds, Indeno[5,4-B]Furan Analogues Were Found To Be The Most Potent And Selective Mt(1) Receptor Ligands And To Have Superior Metabolic Stability. The Optimization Of Substituents Led To (S)-(-)-22B, Which Showed Very Strong Affinity For Human Mt(1) (K(I) = 0.014 Nm), But No Significant

    合成参考文献


    参考文献:10.1055/s-0029-1217818
    摘要:Nishi T, Nakamura Y, Jojima T, Suzuki C, Miyazaki S. Efficient Synthesis of 5-Alkoxy-(3R)-hydroxy-2,3-dihydrospiro[indene-1,4′-piperidines]: A Novel Scaffold for Renin Inhibitors. Synlett. 2009 Aug 17;2009(15):2521–3. doi: 10.1055/s-0029-1217818.
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