4-甲氧基肉桂酸置于aluminum (Iii) Chloride,氯化亚砜,镍,一水合肼,氢化铝,Sodium Hydroxide体系中,用 甲苯 作为反应溶剂,化学反应生成 6-羟基-1-茚酮 参考文献:Bipolar Carrier Transport In Tri-Substituted octyloxy-Truxene Dlc 标题:Bipolar Carrier Transport In Tri-Substituted octyloxy-Truxene Dlc 摘要:In This Study,Bipolar Charge Carrier Transport Of 2,7,12-Trioctyloxytruxene Has Been Studied By A Time-Of-Flight Method. The Substance Studied Exhibits A Hexagonal Columnar Mesophase Of Which Melting And Clearing Points Are 118 Degrees C And 133 Degrees C,Respectively. Ambipolar Electronic Carrier Transports Were Observed In The Mesophase. The Drift Mobility Measurements Reveal It Is In The Order Of 10(-2) Cm(2) V-1 S(-1) In The Col(H) And It Increases To 10(-1) Cm 2 V-1 S(-1) At The Columnar Mesophase-Metastable Phase Transition,Indicating Truxene Is An Interesting Molecular Core For Mesophase Semiconductors. DOI:10.1080/15421406.2011.568891
专利号:US-7476757-B2 优先权日:2005-02-22 标 题:Process for the synthesis of enantiomeric indanylamine derivatives 发明人:BOULTON LEE TERENCE; LENNON IAN CAMPBELL; BAHAR ELIEZER 权利人:TEVA PHARMA 摘要:A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)-propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or pressure hydrogenation in the presenc of an optically active catalyst to reduce 1-indanones. The chiral product, either (S)- or (R)-indanols undergo nucleophilic substitution to produce the named product. In an additional aspect, the invention relates to novel intermediates and compounds, namely, substituted indanones, substituted (S)-indanols and substituted (R)-indanols.
专利号:US-2006199974-A1 优先权日:2005-02-22 标 题:Process for the synthesis of enantiomeric indanylamine derivatives
专利号:US-2008200720-A1 优先权日:2005-02-22 标题:Process for the synthesis of enantiomeric indanylamine derivatives
专利号:US-7375249-B2 优先权日:2005-02-22 标 题:Process for the synthesis of enantiomeric indanylamine derivatives
专利号:US-8580822-B2 优先权日:2006-12-11 标 题:Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors 发明人:BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD 权利人:BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD; REVIVA PHARMACEUTICALS INC 摘要:The present invention provides novel indanone derivatives which can be advantageously used for treating and/or preventing of a medical condition for which inhibition of a cholinesterase is desired.
专利号:AU-2006245349-A1 优先权日:2005-02-22 标题:Improved process for the synthesis of enantiomeric indanylamine derivatives
参考标题:Synthesis Of A Novel Series Of Tricyclic Indan Derivatives As Melatonin Receptor Agonists 作者:Osamu Uchikawa,Kohji Fukatsu,Ryosuke Tokunoh,Mitsuru Kawada,Kiyoharu Matsumoto,Yumi Imai,Shuji Hinuma,Koki Kato,Hisao Nishikawa,Keisuke Hirai,Masaomi Miyamoto,Shigenori Ohkawa |发布日期:2002.9.1 摘要:6-Position Incorporated Into A Furan, 1,3-Dioxane, Oxazole, Pyran, Morpholine, Or 1,4-Dioxane Ring System. Among These Compounds, Indeno[5,4-B]Furan Analogues Were Found To Be The Most Potent And Selective Mt(1) Receptor Ligands And To Have Superior Metabolic Stability. The Optimization Of Substituents Led To (S)-(-)-22B, Which Showed Very Strong Affinity For Human Mt(1) (K(I) = 0.014 Nm), But No Significant
合成参考文献
参考文献:10.1055/s-0029-1217818 摘要:Nishi T, Nakamura Y, Jojima T, Suzuki C, Miyazaki S. Efficient Synthesis of 5-Alkoxy-(3R)-hydroxy-2,3-dihydrospiro[indene-1,4′-piperidines]: A Novel Scaffold for Renin Inhibitors. Synlett. 2009 Aug 17;2009(15):2521–3. doi: 10.1055/s-0029-1217818.