CAS: 6903-79-3; 2-(1-Methylguanidino)Ethyl Dihydrogen Phosphate

[2-[carbamimidoyl(Methyl)Amino]Ethoxy-Hydroxyphosphoryl] 2-[carbamimidoyl(Methyl)Amino]Ethyl Hydrogen Phosphate置于水体系中,化学反应 5.0H,反应生成 磷酸肌肉醇
参考文献:一种肉醇磷酸酯的制备方法
标题:一种肉醇磷酸酯的制备方法
摘要:本发明公开了一种肉醇磷酸酯的制备方法,包括如下步骤,(1)磷酸中分次加入五氧化二磷反应(2)向步骤(1)的反应液中加入肌肉醇磷酸盐,反应生成肉醇磷酸酯二聚物;(3)向步骤(2)的反应液中反应物中加入水;(4)步骤(3)的反应液冷却至室温,加入溶剂,得析出物,抽滤,滤饼用溶剂洗涤,滤干,在80oc下干燥至恒重,得产品;母液减压浓缩,得有机溶剂和磷酸.本发明合成方法中的原料易得,反应中不会产生过多的废弃物,有机溶剂和磷酸可以套用,大大降低污染的排放,生产成本低,废水排放量小,合成收率高,适合工业化生产,且反应所需要求不高,对反应设备侵蚀不大,对环境和人身体影响小.

专利信息

专利号:US-2011105786-A1
优先权日:2009-11-02
标 题 :Creatinol o-phosphate and synthesis method thereof
发明人：ZHANG GUOJI; ZHANG JIASHU
权利人:TIANJIN TIANCHENG PHARMACEUTICAL CO LTD
摘要:A creatinol O-phosphate is formed by chemically reacting a creatinol sulfate of creatinol compound with sulfuric acid to form a protected creatinol sulfate as a transition state of the synthesis process of the creatinol O-phosphate, wherein the protected creatinol is further reacted with one of P 2 O 5 , CIPO 3 H 2 , and POCl 3 to form the creatinol O-phosphate. The method of producing the protected creatinol sulfate includes a step of adding sulfuric acid into a creatinol sulfate to form a protected creatinol sulfate as the protected functional group. Therefore, the creatinol O-phosphate is formed by the process including the steps of chemically reacting the protected creatinol sulfate with one of POCl 3 , CIPO 3 OH 2 , and P 2 O 5 to form a creatinol O-phosphate solution; and crystallizing the creatinol O-phosphate solution to obtain crystallized creatinol O-phosphate.

专利号:US-2014256987-A1
优先权日:2013-03-09
标 题 :Creatinol O-phosphate and synthesis method thereof
发明人：ZHANG GUOJI
权利人:ZHANG GUOJI; TIANJIN TIANCHENG PHARMACEUTICAL CO LTD
摘要:A creatinol O-phosphate is formed by chemically reacting a creatinol sulfate of creatinol compound with sulfuric acid to form a protected creatinol sulfate as a transition state of the synthesis process of the creatinol O-phosphate, wherein the protected creatinol is further reacted with one of P 2 O 5 , CIPO 3 H 2 , and POCl 3 to form the creatinol O-phosphate. The method of producing the protected creatinol sulfate includes a step of adding sulfuric acid into a creatinol sulfate to form a protected creatinol sulfate as the protected functional group. Therefore, the creatinol O-phosphate is formed by the process including the steps of chemically reacting the protected creatinol sulfate with one of POCl 3 , ClPO 3 OH 2 , and P 2 O 5 to form a creatinol O-phosphate solution; and crystallizing the creatinol O-phosphate solution to obtain crystallized creatinol O-phosphate.

专利号:US-11970435-B2
优先权日:2017-05-12
标题:Taste-modified creatine salts, compounds, compositions and uses thereof
发明人：LEBEDYEVA IRYNA; KLUG CHRISTOPHER
权利人:UNIV RES INST INC AUGUSTA
摘要:Provided are embodiments of creatine and creatine ethyl ester (CEE) salts where the anion is an artificial (non-saccharide) taste-modifier. These compounds represent stable white non-hygroscopic solids or semisolids that can readily dissolve in water and buffer solutions. Synthesis of novel creatine salts using environmentally safe solvents such as ethanol resulted in the formation of products in quantitative yields with sodium or potassium chloride as a byproduct. The creatine and creatine alkyl eater derivative salts are stable sweet-tasting compounds that are more palatable to a consumer than creatine or derivatives thereof.

专利号:US-2011105797-A1
优先权日:2009-11-02
标题:Creatinol sulfate and synthesis method thereof
发明人：ZHANG GUOJI; ZHANG JIASHU
权利人:TIANJIN TIANCHENG PHARMACEUTICAL CO LTD
摘要:A chemical compound of creatinol sulfate is formed by chemically reacting N-methyl-amino-ethanol, cyanamide, with sulfuric acid to produce the creatinol sulfate with relatively higher yield rate and purity, wherein the mol ratio of N-methyl-amino-ethanol, sulfuric acid, and cyanamide is approximately 2:1:2.

专利号:IT-8622188-A0
优先权日:1986-10-30
标 题:PROCESS FOR THE SYNTHESIS OF A CREATINOL PHOSPHORIC SALT USEFUL AS A PRECURSOR OF CREATINOL-O-PHOSPHATE, PHOSPHORIC SALT THUS OBTAINED AND DISSYNTHESIS INTERMEDIATE.

专利号:US-2014256986-A1
优先权日:2013-03-09
标 题 :Creatinol sulfate and synthesis method thereof
发明人：ZHANG GUOJI
权利人:ZHANG GUOJI; TIANJIN TIANCHENG PHARMACEUTICAL CO LTD
摘要:A chemical compound of creatinol sulfate is formed by chemically reacting N-methyl-amino-ethanol, cyanamide, with sulfuric acid to produce the creatinol sulfate with relatively higher yield rate and purity, wherein the mol ratio of N-methyl-amino-ethanol, sulfuric acid, and cyanamide is approximately 2:1:2.