CAS: 7240-90-6; (2S,3R,4S,5R,6R)-2-((5-Bromo-4-Chloro-1H-Indol-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

上下游产品

CAS号125328-77-0 6-acetamido-3-b... | CAS号3030-19-1 6-amino-3-bromo... | CAS号1447125-25-8 allyl 6-((2-(al... | CAS号627531-47-9 4-溴-3-氯-2-甲基苯胺 | CAS号125328-80-5 N-(4-溴-3-氯-2-甲基... | CAS号117887-41-9 1H-Indol-3-ol, ... | CAS号59-23-4 半乳糖

N-(4-溴-3-氯-2-甲基苯基)乙酰胺置于吗啉,吡啶,Potassium Permanganate,四(三苯基膦)钯,Potassium Tert-Butylate,水,Sodium Methylate,Silver(I) Acetate,四丁基硫酸氢铵,Sodium Hydride,Magnesium Sulfate,Potassium Carbonate,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,乙醚,二氯甲烷,水,N,N-二甲基甲酰胺,乙腈 作为反应溶剂,化学反应 22.58H,反应生成 5-溴-4-氯-3-吲哚半乳糖苷
参考文献:吲哚乙酸酯作为吲哚氧基糖苷的方便中间体
标题:吲哚乙酸酯作为吲哚氧基糖苷的方便中间体
摘要:使用可扩展的路线以极好的收率获得了具有不同卤化物取代模式的吲哚酸甲酯和烯丙酯.这些关键中间体的相转移糖基化是用各种糖基卤化物进行的.随后温和的银介导的脱羧作用,然后是 Zemplen 脱乙酰作用,以非常好的总产率得到吲哚酚苷.吲哚酚苷是酶筛选和酶活性监测的成熟和广泛使用的工具.过去,它们的合成一直很困难,因此这种新方法导致了各种有用的结构.
DOI:10.1002/ejoc.201301198

专利信息

专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人：KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:US-2025049961-A1
优先权日:2021-12-23
标题 :Scalable and high-purity cell-free synthesis of closed-ended dna vectors
发明人：MONDS RUSSELL; CIPI JORIS; BLACKSTOCK DANIEL JASON; DURANT JOHN CHESTER
权利人:GENERATION BIO CO
摘要:This disclosure provides methods for scalable and high-purity cell-free synthesis of DNA vectors, particularly closed-ended DNA vectors (e.g., ceDNA vectors) having linear and continuous structure for delivery and expression of a transgene. The cell-free synthesis includes digesting a double-stranded DNA construct with at least one restriction endonuclease that is capable of cleaving the construct at cleavage sites, which are distinct from the recognition sites, to release an insert having unique overhangs that regulate the high specificity of the subsequent ligation reaction. The insert is then ligated with inverted terminal repeat (ITR) oligonucleotides to form the closed-ended DNA vector. Corresponding DNA vectors prepared by these methods and related products as well other base and intermediate vectors and constructs associated with the methods are also provided in this disclosure.

专利号:US-2003159164-A1
优先权日:1998-05-29
标 题:Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products
发明人：KOPCHICK JOHN JOSEPH; KELDER BRUCE; HUANG YUNG-SHENG; KIRCHNER STEPHEN J; MUKERJI PRADIP
摘要:The invention generally relates to synthesis of essential fatty acids and their derivatives, long-chain polyunsaturated fatty acids (LC-PUFAs) and eicosanoids in transfected cells and in transgenic animals.

专利号:US-6040423-A
优先权日:1990-08-31
标题 :Process for synthesis of peptides
发明人：FRANK RONALD; GULER SINAN
权利人:BIOTECHNOLOG FORSCHUNG GMBH
摘要:The invention relates to a process for the rapid synthesis of support-bound or free peptides, a device for carrying out the process, a flat material with peptides bound to it which are prepared according to the process, and to a use for the flat material.

专利号:US-8278483-B2
优先权日:2006-02-07
标题:Process for synthesis of glycomimicking cationic amphiphiles
发明人：MAHIDHAR YENUGONDA VENKATA; CHAUDHURI ARABINDA; MUKHERJEE RAMA
权利人:MAHIDHAR YENUGONDA VENKATA; CHAUDHURI ARABINDA; MUKHERJEE RAMA; COUNCIL SCIENT IND RES
摘要:The present invention provides processes for the synthesis of novel Shikimic acid head-group containing non-toxic cationic amphiphiles capable of facilitating transport of biological macromolecules into cells.

专利号:US-5258292-A
优先权日:1990-11-28
标题:Enzymic process for the synthesis of ammonium adipate
发明人：YEH PATRICE; MAYAUX JEAN-FRANCOIS; CERBELAUD EDITH; PETRE DOMINIQUE
权利人:RHONE POULENC CHIMIE
摘要:The invention relates to an enzymic process for the synthesis of ammonium adipate by the hydrolysis of adipamide and/or ammonium adipamate by means of a particular polypeptide or a recombinant microorganism generating this polypeptide.