CAS: 7449-74-3; N-Methyl-N-(Trimethylsilyl)Acetamide

相似化合物

24589-78-4 13435-12-6 996-50-9

N-Methyl-Trimethylsilylacetamid 180.0~200.0 °C,1.07 Kpa 条件下,反应生成 N-甲基-N-(三甲基硅基)乙酰胺
参考文献:烯酮与甲硅烷基化胺或酰胺的相互作用
标题:烯酮与甲硅烷基化胺或酰胺的相互作用
摘要:在对乙烯酮与单或二烷基氨基硅烷的相互作用的研究中,观测到许多新的重排.当受到烯酮作用时,二烷基氨基硅烷根据所施加的条件,会反应生成β-甲硅烷氧基乙烯基乙酸(i)的酰胺(路线" A",方案a)或甲硅烷基乙酸的酰胺(II)(路线" B"," C").在两种情况下,均分离出中间体α-甲硅烷氧基乙烯基二烷基胺(iii),可以将其重新排列以得到酰胺(II).
DOI:10.1016/s0022-328X(00)88613-1

专利信息

专利号:US-2022298204-A1
优先权日:2019-07-05
标题 :Synthesis of a-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

专利号:EP-3792250-A1
优先权日:2019-09-13
标题:Synthesis of alpha-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

专利号:WO-9741093-A1
优先权日:1996-04-30
标 题:Methods for the synthesis of fmoc protected amines
发明人：BAER TED ALLEN; RAILLARD STEPHEN PETER
权利人:AFFYMAX TECH NV; BAER TED ALLEN; RAILLARD STEPHEN PETER
摘要:Methods for the synthesis of Fmoc-protected amines are provided. These methods involve the treatment of an amine component with a silylating agent and then an activated Fmoc-reagent. The methods can be conducted under anhydrous conditions.

专利号:US-9605019-B2
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids
发明人：VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL
权利人:VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL; WAVE LIFE SCIENCES LTD
摘要:The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.

专利号:EP-0135088-B1
优先权日:1983-08-13
标 题 :7-Amino-3[1-pyridiniomethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-2-carboxylates, process for their preparation and their use as intermediates in the synthesis of beta-lactam antibiotics
摘要:1. Compounds of the general formula (1) see diagramm : EP0135088,P12,F1 in which R represents hydrogen or methoxy, and X and Y, independently of one another, represent the following meanings : hydrogen ; halogen ; cyano ; hydroxyl ; C1 -C4 -alkoxy ; phenoxy ; amino, C1 -C4 -alkylamino, C1 -C4 -dialkylamino or C1 -C4 -alkanoylamino ; carboxyl ; C1 -C4 -alkanoyl ; benzoyl ; phenyl-C1 -C4 -alkanoyl ; C1 -C4 -alkoxycarbonyl ; sulphamoyl ; carbamoyl ; N-C1 -C4 -alkyl-, N,N-C1 -C4 -dialkyl- or N-C1 -C4 -alkoxycarbonylcarbamoyl ; allophanoyl and 4-C1 -C4 -alkylallophanoyl ; C1 -C4 -alkylsulphonyl ; C1 -C4 -alkylthio ; C1 -C6 -alkyl or alkenyl, C3 -C7 -cycloalkyl or cycloalkenyl, phenyl, heterocyclyl having 5- to 6-membered rings and 1 to 4 heteroatoms from the group comprising O, N and/or S, phenylalkyl or heterocyclylalkyl in the above mentioned meaning with 1 to 2 C atoms in the alkyl moiety, each of which is optionally substituted one or more times by hydroxyl, C1 -C4 -alkoxy, halogen, cyano, carboxyl and C1 -C4 -alkoxycarbonyl, C1 -C4 -alkanoyl, C1 -C4 -alkylsulphonyl or -sulphinyl, amino, or mono- or di-C1 -C4 -alkylamino, or C1 -C4 -alkoxyimino, excepting the radicals hydrogen-hydrogen, amino/hydrogen and carbamoyl/hydrogen ; or X and Y together represent a carbocyclic radical which is fused to the pyridine ring in 2.3 or 4.5 position and has 5 - 7 carbon atoms which are optionally replaced by O, S or N heteroatoms.

专利号:WO-2024146948-A1
优先权日:2023-01-05
标题:Peptide synthesis method involving sterically hindered tri-tert-butyl-tryptophan (tbt) residue
发明人：EKSTEEN JACOBUS JOHANNES; SVENDSEN JOHN SIGURD; MALMEDY FLORENCE; GUEVARA JONATHAN
权利人:AMICOAT AS
摘要:The invention is directed to a method of peptide synthesis comprising reacting a compound of Formula (I) or a salt thereof with a carbodiimide reagent to form an O-acylisourea intermediate; reacting the O-acylisourea intermediate with an additive to form an activated ester; and reacting the activated ester with an amino-containing moiety which is an amino acid, a peptide or a salt thereof comprising an amino group, wherein the amino group forms an amide bond with the carbonyl marked * in Formula (I); wherein the compound of Formula (I) has the structure: and wherein R1 and R2 are as defined in the disclosure. The invention is also directed to a compound of Formula (III) as defined in the disclosure or a salt thereof.