CAS: 772-38-3; 1-(Tert-Butyl)-4-Ethynylbenzene

上下游产品

CAS号35779-04-5 1-叔丁基-3-碘苯 | CAS号3972-65-4 对叔丁基溴苯 | CAS号1066-54-2 三甲基硅基乙炔 | CAS号1208-65-7 3-(4-(叔丁基)苯基)丙烯酸 | CAS号109347-45-7 4-叔丁基笨乙醛 | CAS号109034-26-6 ETHYL 3-(4-TERT... | CAS号4210-32-6 对叔丁基苯甲腈 | CAS号29778-26-5 4-t-Butyl diphe... | CAS号30095-47-7 2-溴-1-(4-(叔丁基)苯基)乙酮 | CAS号1746-23-2 4-叔丁基苯乙烯 | CAS号1134201-55-0 2-(p-tert-butyl... | CAS号1228105-34-7 2-(4-tert-butyl... | CAS号1228105-37-0 (3E)-4-(4-tert-...

2-(4-叔丁基苯)乙醇置于硫酰氟,Potassium Carbonate,二甲基亚砜,Cesium Fluoride体系中,用 二甲基亚砜 作为反应溶剂,化学反应 4.0H,反应生成 4-叔-丁基苯基乙炔
参考文献:So2F2 介导的氧化脱氢和醇脱水反应生成炔
标题:So2F2 介导的氧化脱氢和醇脱水反应生成炔
摘要:通过 So2F2 促进的脱水和脱氢过程,以高产率(超过 40 个实例,高达 95% 的产率)实现了从廉价,丰富的醇直接合成炔烃.sp3-Sp3 (Cc) 键向 Sp-Sp (C≡c) 键的这种直接转变只需要在温和条件下廉价且容易获得的试剂(无过渡金属).粗炔烃足够不含杂质,可以直接用于进一步的转化,如区域选择性 Huisgen 炔烃-叠氮化物与 Phn3 环加成反应所示,得到 1,4-取代的 1,2,3-四唑(16 个例子,高达 92%产率)和 Sonogashira 偶联(10 个例子,产率高达 77%).
DOI:10.1021/jacs.8B10069

专利信息

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-2003082830-A1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A9
优先权日:1998-07-25
标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A2
优先权日:1998-07-25
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:US-9475756-B2
优先权日:2012-03-05
标题:Difluoromethylation of aryl and vinyl iodides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:Selectively fluorinated molecules are important as materials, pharmaceuticals, and agrochemicals, but their synthesis by simple, mild, laboratory methods is challenging. We report a straightforward method for the cross-coupling of a difluoromethyl group with readily available reagents to form difluoromethylarenes. The reaction of electron-neutral, electron rich, and sterically hindered aryl and vinyl iodides with the combination of CuI, CsF and TMSCF 2 H leads to the formation of difluoromethylarenes in high yield with good functional group compatibility. This transformation is surprising, in part, because of the prior observation of the instability of CuCF 2 H.

专利号:US-6448443-B1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products