CAS: 87-44-5; (1R,9S,E)-4,11,11-Trimethyl-8-Methylenebicyclo[7.2.0]Undec-4-Ene

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Farnesyl Pyrophosphate 反应生成 14-Hydroxy-4,5-Dihydro-β-Caryophyllene,Pyrophosphoric Acid
参考文献:Nonseed Plant Selaginella Moellendorffii Has Both Seed Plant And Microbial Types Of Terpene Synthases
标题:Nonseed Plant Selaginella Moellendorffii Has Both Seed Plant And Microbial Types Of Terpene Synthases
摘要:萜烯合酶(Tps)是植物和其他生物合成萜烯类次生代谢产物的关键酶.为了了解植物中这些酶的广泛多样性的基础,我们研究了一种非种子植物--墨角藻.该物种的基因组发现包含两种不同类型的tps基因.第一类基因被指定为墨角藻tps基因(Smtpss),由18个成员组成.Smtpss与典型的种子植物tps具有共同的祖先.选定的smtpss被证明编码二萜烯合酶.第二类基因被指定为墨角藻微生物tps样基因(Smmtpsls),由48个成员组成.系统发育分析表明,Smmtpsls与微生物tps比其他植物tps更密切相关.选定的smmtpsls被确定为单萜烯和倍半萜烯合酶.大多数产物是典型的单萜烯和倍半萜烯,这些产物以前已经被证明是由经典植物tps酶合成的.一些经过表征的smmtpsls的体外产物在用真菌诱导剂alamethicin处理的墨角藻植物的空气中被检测到,表明它们也在完整的植物中形成.墨角藻基因组中存在两种不同类型的tps,这提出了其他植物物种中的tps也可能具有不止一个进化起源的可能性.
Doi:10.1073/Pnas.1204300109

专利信息

专利号:US-11046978-B2
优先权日:2016-03-16
标 题:Synthesis of isoprenoids and derivatives
发明人：GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG
权利人:UNIV RICE WILLIAM M
摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.

专利号:US-2024240209-A1
优先权日:2021-04-20
标 题:Synthesis of enantiopure cis-a-irone from a renewable carbon source
发明人：CHEN XIXIAN; ZHANG CONGQIANG; T REHKA; SHUKAL SUDHA; SMITH DEREK; ANDRÉ ISABELLE; JEREMY ESQUE
权利人:AGENCY SCIENCE TECH & RES; INSTITUT NATIONAL DE RECH POUR L AGRICULTURE LALIMENTATION ET LENVIRONMENT; CENTRE NAT RECH SCIENT; INSTITUT NAT DES SCIENCES APPLIQUEES DE TOULOUSE
摘要:Synthesis of enantiopure cis-α-irone from a renewable carbon source Disclosed herein are natural and synthetic enzymes capable of performing a method of producing cis-α-irone. The method comprises providing an enzyme capable of converting psi-ionone to cis-α-irone; and contacting the enzyme and psi-ionone under suitable conditions to produce cis-α-irone. The enzyme may be a methyltransferase from Streptomyces albireticuli (SaMT), a promiscuous bifunctional methyltransferase/cyclase (pMT1) enzyme from Streptomyces, or a modified pMT1 enzyme with at least one substitution. The enzymes allow the in-vivo and in-vitro production of cis-α-irone including the use of glucose as feedstock for the biotransformation into cis-α-irone.

专利号:WO-2015030681-A1
优先权日:2013-08-30
标题:In vitro synthetic multi-biocatalytic system for the synthesis of isoprenoids and isoprenoid precursors
发明人：TOO HENG PHON; CHEN XIXIAN; ZOU RUIYANG; ZHANG CONQIANG
权利人:UNIV SINGAPORE
摘要:Disclosed herein are in vitro multi-biocatalytic systems for the synthesis of isoprenoid precursors and isoprenoids, as well as methods of producing isoprenoid precursors or isoprenoids in vitro using the systems disclosed herein.

专利号:US-11384367-B2
优先权日:2016-12-22
标题:Synthesis of bioproducts from lignin-derived aromatics by genetically modified microorganisms
发明人：GLADDEN JOHN M; SKERKER JEFFREY M; KEASLING JAY D; KIRBY JAMES; YAEGASHI JUNKO
权利人:UNIV CALIFORNIA; NAT TECH & ENG SOLUTIONS SANDIA LLC; BATTELLE MEMORIAL INSTITUTE FOR MANAGEMENT AND OPERATION OF PACIFIC NORTHWEST NAT LABORATORY; NATIONAL TECH AND ENGINEERING SOLUTIONS OF SANDIA LLC
摘要:The present invention provides for a method of converting a depolymerized lignin aromatic compound into a bioproduct, comprising: (a) providing a composition comprising a depolymerized lignin aromatic compound, optionally a depolymerized cellulose, and optionally a depolymerized hemicellulose, and (b) introducing a genetically modified microorganism to the composition, wherein the genetically modified microorganism is capable of converting the depolymerized lignin aromatic compound into a bioproduct; such that the depolymerized lignin aromatic compound is converted into a bioproduct.

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.