69-72-7 = 96-97-9 + 85-38-1 反应条件:1.1 Reagents: Zinc,Bis(Dinitrogen Tetraoxide)Bis(Nitrato-Ko)- Solvents: Dichloromethane; 5 Min,Rt 标题:Nitration Of Aromatic Compounds By Zn(No3)2.2N2O4 And Its Charcoal-Supported System 作者:Iranpoor,Nasser; Et Al 参考文献:Synthetic Communications 日期:2005 卷标:35(2) 页码:263-270]
69-72-7 = 96-97-9 + 85-38-1 反应条件:1.1 Reagents: Nitric Acid Catalysts: Zirconium Dioxide (Co-Support With Zirconia,Impregnated With Phosphoric Acid),Phosphoric Acid (On Titania/zirconia Support),Titania (Co-Support With Zirconia,Impregnated With Phosphoric Acid) Solvents: 1,2-Dichloroethane; 5 Min,Reflux 标题:Fast And Efficient Nitration Of Salicylic Acid And Some Other Aromatic Compounds Over H3Po4/tio2-Zro2 Using Nitric Acid 作者:Kalbasi,Roozbeh Javad; Et Al 参考文献:Chinese Journal Of Chemistry 日期:2010 卷标:28(3) 页码:397-403]
2516-96-3 = 96-97-9 反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Pyridine,Copper Solvents: Water; 15 Min,Rt 标题:Synthesis Of Salicylic Acid Derivatives In Presence Of Ultrasonic Irradiation Using Water As Solvent 作者:Palacios,Maite L. Docampo; Comdom,Rolando F. Pellon 参考文献:Synthetic Communications 日期:2003 卷标:33(10) 页码:1783-1787]
2516-96-3 = 96-97-9 反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Water; 20 Min,25 - 30 °C; 25 °C -> 130 °C; 5 H,125 - 130 °C; 130 °C -> 25 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 1 H,Ph 1.0 - 2.0,25 °C 标题:Compositions And Methods For The Treatment Of Inflammatory Bowel Disease 参考文献:United States]
2516-96-3 = 96-97-9 反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Water; 20 Min,25 - 30 °C; 30 °C -> 130 °C; 5 H,130 °C; 130 °C -> 25 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 1 H,Ph 1 - 2,25 °C 标题:Green Approach For Large Scale Process Of Mesalamine,An Antiinflammatory Agent 作者:Srinivasan,Neti; Lilakar,Jaydeepkumar 参考文献:Rasayan Journal Of Chemistry 日期:2009 卷标:2(3) 页码:688-690]
3970-35-2 + 2516-96-3 = 96-97-9 + 85-38-1 反应条件:1.1 Reagents: Sodium Hydroxide; 20 Min,20 Bar,180 °C 标题:Advanced Real-Time Process Analytics For Multistep Synthesis In Continuous Flow 作者:Sagmeister,Peter; Et Al 参考文献:Angewandte Chemie 日期:2021 卷标:60(15) 页码:8139-8148]
118-91-2 = 96-97-9 + 85-38-1 反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid; 47.5 S,35 °C1.2 Reagents: Isopropyl Acetate,Water2.1 Reagents: Sodium Hydroxide; 20 Min,20 Bar,180 °C 标题:Advanced Real-Time Process Analytics For Multistep Synthesis In Continuous Flow 作者:Sagmeister,Peter; Et Al 参考文献:Angewandte Chemie 日期:2021 卷标:60(15) 页码:8139-8148
5-氨基水杨酸置于oxone,Sodium Hydroxide体系中,用 水,丙酮 作为反应溶剂,以74%的收率获得产物5-硝基水杨酸 参考文献:A Mild Oxidation Of Aromatic Amines 标题:A Mild Oxidation Of Aromatic Amines 摘要:Several Primary Aromatic Amines Have Been Converted To The Corresponding Nitro Compounds In Good Yields. The Oxidant Was Oxone(R) (Potassium Peroxymonosulfate) And The Reactions Were Performed In 5 To 20% Aqueous Acetone And Buffered With Sodium Bicarbonate. DOI:10.1016/0040-4039(95)00281-G
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-4764263-A 优先权日:1987-05-18 标 题:Electrochemical synthesis of substituted aromatic amines in basic media 发明人:GREGORY THOMAS D; STUTTS KENNETH J 权利人:DOW CHEMICAL CO 摘要:Substituted amino aromatic compounds such as 3-amino-4-hydroxybenzoic acid are prepared by electrolytically reducing the corresponding nitro aromatic compound in a basic medium at temperatures below 60° C. and current densities greater than 50 milliamps per square centimeter. The aminohydroxybenzoic acids are useful in the preparation of polybenzoxazoles which are used to make fibers and composites having high strength and thermal stability.
专利号:US-6720289-B2 优先权日:2001-11-09 标题 :Formulation and method for increasing the essential oil content in aromatic crops 发明人:KALRA ALOK; KATIYAR NEETU; KUMAR SUSHIL; KHANUJA SUMAN PREET SINGH 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a formulation for increasing the synthesis and accumulation of essential oil in aromatic plants and other plants. The formulation disclosed herein comprises a resistance inducer, such as an isomer of amino butyric acid or another amino acid, which is capable of increasing the synthesis of essential oil in an aromatic plant. The formulation may further comprise secondary metabolites as well as a carrier. Aromatic plants that may be used in the present invention include, but are not limited to, rose-scented geranium (Pelargonium graveolens) and menthol mint (Mentha arvensis). The present invention also provides a method of increasing the essential oil content in aromatic crops and other plants.
专利号:US-9382462-B2 优先权日:2013-03-15 标 题:Metal ligand-containing prepolymers, methods of synthesis, and compositions thereof 发明人:RAO CHANDRA; DENG JUN; LIN RENHE 权利人:PRC DESOTO INT INC 摘要:Metal ligand-containing prepolymers, compositions containing metal ligand-containing prepolymers, methods of synthesizing metal ligand-containing prepolymers and the use of metal ligand-containing prepolymers in aerospace sealant applications are disclosed. The metal ligand-containing prepolymers have metal ligands incorporated into the backbone of the prepolymer. Cured sealant compositions comprising the metal ligand-containing prepolymers exhibit enhanced properties suitable for aerospace sealant applications.
专利号:US-6369074-B1 优先权日:1992-12-10 标 题:Aminomethylene substituted non-aromatic heterocycles and use as substance P antagonists 发明人:HOWARD HARRY R; O'NEILL BRIAN T 权利人:PFIZER 摘要:The present invention relates to novel aminomethylene substituted non-aromatic heterocycles and, specifically, to compounds of the formula n wherein W, R 1 , R 2 , R 3 , A, X′, Y′ and Z′ are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formulae Ia and Ib are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
专利号:CN-110229104-B 优先权日:2019-06-18 标 题 :A method for the synthesis of tetrahydroquinoline compounds catalyzed by titanocene/Brönsted acid from aromatic amines and α-ketoesters
[参考文献]: David Calligaris, Et Al. Maldi Mass Spectrometry Imaging Analysis Of Pituitary Adenomas For Near-Real-Time Tumor Delineation. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9978-83.
合成参考文献
摘要:Schnürch, M.; Hämmerle, J.; Stanetty, P., Science of Synthesis Knowledge Updates, (2010) 1, 154. 摘要:Hitomi, Y.; Arakawa, K., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 297. 摘要:G. E. Dunn and F. L. Kung, Can. J. Chem. 44, 1261 (1966). 摘要:L. G. Bray, J. F. J. Dippy, S. R. C. Hughes and L. W. Laxton, J. Chem. Soc. 1957, 2405.