CAS: 2748-02-9; (S)-Tert-Butyl 2-Amino-4-Methylpentanoate Hydrochloride

相似化合物

13081-32-8 328-38-1 328-39-2

上下游产品

CAS号21691-53-2 L-亮氨酸叔丁酯盐酸盐 | CAS号58822-25-6 [Leu5]-脑啡肽 | CAS号81678-16-2 白氨酸脑啡肽乙酸盐 | CAS号122237-16-5 DC-FM-bar-Phe-L...

Dl-亮氨酸,醋酸叔丁酯 以29.4的收率获得l-亮氨酸叔丁酯盐酸盐
参考文献:一种乌苯美司的新型合成工艺
标题:一种乌苯美司的新型合成工艺
摘要:本发明公开一种乌苯美司的新型合成工艺,以(2S,3R)-3-氨基-2-羟基-4-苯基丁酸为原料,与二碳酸二叔丁酯反应,且二碳酸二叔丁酯采用分批逐次的加入方式,制备获得中间体i,中间体i与l-亮氨酸叔丁酯盐酸盐反应制备获得中间体ii,其中l-亮氨酸叔丁酯盐酸盐作为优选,有利于提高中间体ii的收率和纯度,中间体ii在酸碱体系下分别脱去保护基团叔丁氧羰酰基和叔丁酯,此操作只需通过酸碱体系调节酸碱值就能有效将保护基团高效脱去,提高乌苯美司成品的收率和纯度.

专利信息

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-4351762-A
优先权日:1981-03-10
标题:Rapid, quantitative peptide synthesis using mixed anhydrides
发明人：VERLANDER MICHAEL S; FULLER WILLIAM D; GOODMAN MURRAY
权利人:BIORESEARCH INC
摘要:In the synthesis of a polypeptide chain wherein an N alpha -urethane-protected amino acid mixed anhydride is coupled with an amino-unprotected second amino acid, the improvement comprising conducting said coupling at room temperature or above. This method provides rapid, essentially quantitative reactions without the necessity for reduced temperatures. The method is particularly useful in the solid-phase synthesis of peptides where shortened coupling cycles and improved yields of substantially pure products are obtained.

专利号:US-12441760-B2
优先权日:2013-08-29
标 题 :Amino diacids containing peptide modifiers
发明人：BARLOS KLEOMENIS; GATOS DIMITRIOS; BARLOS KOSTAS K; VASILEIOU ZOI
权利人:CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S A
摘要:The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula (1) in the synthesis of peptide derivatives.

专利号:US-6271345-B1
优先权日:1996-07-03
标 题 :Enzyme cleavable linker bound to solid phase for organic compound synthesis
发明人：WALDMANN HERBERT; SAUERBREI BERND; GRETHER UWE
权利人:BASF AG
摘要:An enzyme cleavable linker is prepared on which organic compounds are synthesized when the linker is bound to a solid phase. The linker contains a functional group on which a synthesized organic compound is bound when synthesis takes place, and a recognition site for a hydrolytic enzyme. Reacting the linker with the enzyme causes the linker to fragment at a site different from the recognition site to liberate the synthesized organic compound. The solid phase may be a crosslinked polyacrylamide containing an amino group for attaching the linker, and the linker is bound to the solid phase via a spacer. The spacer is attached to the solid phase by an ester, ether, amide or amine linkage, or a sulfide or phosphate linkage. In a specific reaction of forming a solid phase containing the linker, 2-acetoxy-5-hydroxymethylbenzoic acid is attached to an amino group-containing polymer via a spacer followed by conversion to a chloroformic ester.

专利号:US-6339160-B1
优先权日:1997-07-17
标题:Metalloproteinase inhibitors, their therapeutic use and process for the production of the starting compound in the synthesis thereof
发明人：POLITI VINCENZO; GAVUZZO ENRICO; GALLINA CARLO; STAZIO GIOVANNI DI; D ALESSIO SILVANA; SELLA ANTONIO; PIAZZA CINZIA; GIORDANO CESARE; GORINI BARBARA; PANINI GABRIELLA; PARADISI MARIO PAGLIALUNGA; CIRILLI MAURIZIO; POCHETTI GIORGIO; MAZZA FERNANDO
权利人:POLIFARMA SPA; CONSIGLIO NAZIONALE RICERCHE
摘要:Objects of the present invention are compounds of a peptido-mimetic character having the capacity of acting as inhibitors of metalloproteinases produced by venom of snake, and of other metalloproteinases of human origin which have been put in relation with various pathologies in man, including tumoral growth and metastatization, aterosclerosis, multiple sclerosis, Alzheimer's disease, osteoporosis, hypertension, rheumatoid arthritis and other inflammatory diseases. n Object of the present invention is also the procedure for the production of diethylester of (1)-phosphotryptophan, as an initial product necessary to synthesize all compounds mentioned above.

专利号:WO-2023040981-A1
优先权日:2021-09-20
标 题:Methods and compositions for weight management
发明人：HUA NG MENG; WANG RUIQI RACHEL; LIANG KUN; ZHENG ZIPENG; YANG JIE
权利人:AEGOGEN SUZHOU LTD
摘要:This present application relates to the use of small molecules for weight management, prevention of aging and the treatment of associated conditions and diseases. The present application also provides for the synthesis of some of the molecules and the administration of these molecules for drug discovery, nutrition and cosmeceutical purposes.