专利号:US-11040938-B2 优先权日:2016-07-27 标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts 发明人:MA BING; PAN SHUAI 权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH 摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.
专利号:US-5656634-A 优先权日:1991-03-21 标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) 发明人:CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J 权利人:PFIZER 摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
专利号:US-10857530-B2 优先权日:2015-12-10 标题 :Olefin metathesis catalysts 发明人:JOHNS ADAM M; MONTGOMERY T PATRICK; AHMED TONIA S; GRUBBS ROBERT H; PEDERSON RICHARD L 权利人:UMICORE AG & CO KG; CALIFORNIA INST OF TECHN 摘要:This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.
专利号:EP-3590340-B1 优先权日:2010-09-01 标 题:Intermediates for the synthesis of fungicidal pyrazoles
专利号:CN-108658850-A 优先权日:2018-04-28 标题:A kind of fluorine-containing pyridine imine ligand, its transition metal complex and its application in the synthesis of polyisoprene
专利号:US-2019152896-A1 优先权日:2016-07-27 标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts
[参考文献]: Shaun R Selness, Et Al. Design, Synthesis And Activity Of A Potent, Selective Series Of N-Aryl Pyridinone Inhibitors Of P38 Kinase. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4059-65.
合成参考文献
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