CAS: 40381-90-6; 2,6-Dichloropyridine-3-Carbonitrile

上下游产品

CAS号76175-82-1 N-(2,6-dichloro... | CAS号91467-46-8 3-Cyano-6-hydro... | CAS号62068-78-4 2,6-二氯烟酰胺 | CAS号35441-10-2 1,2-二氢-6-羟基-2-氧... | CAS号38496-18-3 2,6-二氯烟酸 | CAS号58584-83-1 2,6-二氯吡啶-3-羰酰氯 | CAS号58819-72-0 2,6-二甲氧基吡啶-3-甲醛 | CAS号121643-47-8 2-Chloro-6-meth... | CAS号121643-46-7 6-氯-2-甲氧基-3-吡啶甲腈 | CAS号121643-45-6 2,6-二甲氧基吡啶-3-甲腈 | CAS号95652-80-5 2-氯-6-甲氧基烟碱醛 | CAS号95652-81-6 6-氯-2-甲氧基-吡啶-3-甲醛

2,6-二氯烟酰胺置于三氯氧磷体系中,用 四氢呋喃 作为反应溶剂,化学反应 18.0H,以30%的收率获得产物2,6-二氯烟腈
参考文献:通过化学设计策略研究吡啶 3-取代基对 3-取代 2,6-二氯吡啶与 1-甲基哌嗪的亲核芳香取代反应中区域选择性的影响
标题:通过化学设计策略研究吡啶 3-取代基对 3-取代 2,6-二氯吡啶与 1-甲基哌嗪的亲核芳香取代反应中区域选择性的影响
摘要:化学设计策略已用于选择 3-取代的 2,6-二氯吡啶,用于与 1-甲基哌嗪的亲核芳香取代反应.目的是研究这些反应中区域选择性对其亲脂性 (Pi),大小 (Mr) 和诱导效应 (σp) 表示的吡啶 3-取代基特征的依赖性.有趣的是,区域选择性与这些参数中的任何一个都不相关,但与 Verloop 空间参数 B1 具有统计学意义,如 P 值 0.006 (R2 = 0.45) 所示.这意示靠近吡啶环的庞大的 3-取代基诱导朝向 6-位的区域选择性.在实际合成中有用的是用羧酸3-取代基及其前体或衍生物获得的不同区域选择性.因此,以乙腈作为反应溶剂,3-羧酸酯和3-酰胺取代基优先得到2-异构体(6-异构体的比例为9:1),而3-氰基和3-三氟甲基取代基优先得到6-异构体.异构体(2-异构体的比例为 9:1).2,6-二氯-3-(甲氧基羰基)吡啶与 1-甲基哌嗪在 21 种不同溶剂中反应中吡啶 2 位的区域选择性
DOI:10.1002/ejoc.201200978

专利信息

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

专利号:MX-2007000198-A
优先权日:2004-07-06
标 题:PROCESS FOR THE PREPARATION OF CARBOXAMIDE-PYRIDINE DERIVATIVES USED AS INTERMEDIARIES IN THE SYNTHESIS OF ANTAGONISTS OF THE NK-1 RECEIVER.

专利号:EP-1776342-B1
优先权日:2004-07-06
标题 :Process for preparing carboxamide pyridine derivatives used as intermediates in the synthesis of nk-1 receptor antagonists

专利号:EP-1776342-A1
优先权日:2004-07-06
标 题 :Process for preparing carboxamide pyridine derivatives used as intermediates in the synthesis of nk-1 receptor antagonists

专利号:WO-2006002860-A1
优先权日:2004-07-06
标 题 :Process for preparing carboxamide pyridine derivatives used as intermediates in the synthesis of nk-1 receptor antagonists