CAS: 417721-69-8; 4-Chloro-3-Iodopyridin-2-Amine

相似化合物

868733-96-4 670253-37-9 1228666-03-2

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(4-chloro-3-iodopyridin-2-yl)-carbamic acid tert-butyl ester 2-Amino-4-chloropyridine tert-butyl (4-chloropyridin-2-yl) carbamate 4-(2-fluoro-4-nitrophenoxy)-3-iodopyridin-2-amine 3-Iodo-4-(4-nitrophenoxy)-2-pyridinamine 9-chloro-2-trityl-2H-pyrazolo[3,4-c][1,8]naphthyridin-4(5H)-one 4-(2,5-difluorophenoxy)-3-iodopyridin-2-amine

4-氯吡啶-2-羧酸叔丁酯置于正丁基锂,四甲基乙二胺,氢溴酸体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 2.17H,反应生成 4-氯-3-碘吡啶-2-胺
参考文献:7,8-二卤代咪唑并[1,2-A]吡啶的区域控制微波辅助双功能化:一种单锅双偶联方法.
标题:7,8-二卤代咪唑并[1,2-A]吡啶的区域控制微波辅助双功能化:一种单锅双偶联方法.
摘要:7-氯-8-碘-和 8-氯-7-碘咪唑并[1,2-A] 吡啶 1A-E置于2 位不同取代的反应性,对 Suzuki-Miyaura,Sonogashira 和 Buchwald-Hartwig 交叉-偶联反应以及氰化被评估.提出了各种方法来在两个位置引入芳基,杂芳基,炔,胺或氰基,这取决于位置 2 中存在的取代基的性质.在这两个系列中,碘原子的取代完全是区域选择性的,困难在于在第二步中取代氯原子.到目前为止,通过 Suzuki-Miyaura 交叉偶联只能引入杂(芳基)基团.我们克服了并行评估两种区域异构体的问题.还研究了双耦合方法,允许一锅 Suzuki/suzuki,
DOI:10.3390/molecules170910683

专利信息

专利号:WO-2023071314-A1
优先权日:2021-10-29
标 题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound

专利号:US-12331058-B2
优先权日:2021-10-29
标 题:SHP2 and CDK4/6 dual-target inhibitory compound and pharmaceutical composition containing the same
发明人：WU XIAOXING; CHEN XIAOYU; LI WENQIANG; Shu Chengxia; LUO GUANGMEI; YANG KEXIN
权利人:UNIV CHINA PHARMA
摘要:The present invention belongs to the field of medicinal chemistry, and particularly relates to synthesis, a preparation method and the use of an inhibitor containing dual targets SHP2 and CDK4/6, wherein the inhibitor comprises three compounds of general formulas I-III and pharmaceutically acceptable salts, enantiomers, diastereomers, tautomers, solvates, polymorphs or prodrugs thereof. According to the present invention, a class of brand-new SHP2 and CDK4/6 dual-target inhibitors are prepared by means of a pharmacophore fusion and reasonable drug design method, so that the problems of drug resistance, poor drug effect, etc., of the existing SHP2 inhibitor and CDK4/6 inhibitor are solved; the great significance of the present invention is providing the first SHP2 and CDK4/6 dual-target inhibitor, which provides a basis for solving the problem of drug resistance of kinase and phosphatase in the later period.

专利号:EP-4410794-A1
优先权日:2021-10-29
标题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound

专利号:CA-3236558-A1
优先权日:2021-10-29
标 题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound