CAS: 518-17-2; Evodiamine

上下游产品

CAS号4894-26-2 4,9-二氢-3H-吡啶并(3... | CAS号10328-92-4 N-甲基靛红酸酐 | CAS号61-54-1 色胺 | CAS号118-48-9 靛红酸酐 | CAS号33284-02-5 2-amino-N-[2-(1... | CAS号60941-86-8 3-[2-(1H-indol-... | CAS号119-68-6 2-(甲氨基)苯甲酸

吴茱萸碱置于sodium Hydride,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,水,N,N-Dimethyl-D6-Formamide 作为反应溶剂,化学反应 10.5H,反应生成 吴茱萸碱
参考文献:Quinazolinecarboline Alkaloid Evodiamine As Scaffold For Targeting Topoisomerase I And Sirtuins
标题:Quinazolinecarboline Alkaloid Evodiamine As Scaffold For Targeting Topoisomerase I And Sirtuins
摘要:This Paper Reports The Synthesis Of A Series Of Evodiamine Derivatives. We Assayed The Ability To Inhibit Cell Growth On Three Human Tumour Cell Lines (H460,Mcf-7 And Hepg2) And We Evaluated The Capacity To Interfere With The Catalytic Activity Of Topoisomerase I Both By The Relaxation Assay And The occurrence Of The Cleavable Complex. Moreover,Whose Effect On Sirtuins 1,2 And 3 Was Investigated. Finally,Molecular Docking Analyses Were Performed In An Attempt To Rationalize The Biological Results. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2013.09.030

专利信息

专利号:WO-2022244943-A1
优先权日:2021-05-21
标题 :Method for predicting recurrence of lung cancer, and pharmaceutical composition for recurrence inhibition
发明人：LEE HO-YOUNG
权利人:SEOUL NAT UNIV R&DB FOUNDATION
摘要:The present invention relates to: a method for providing information necessary in predicting the recurrence of lung cancer; a pharmaceutical composition for inhibiting the recurrence of lung cancer; and the like. Since the present inventors have identified that in slow-cycling cancer cells responsible for lung cancer recurrence, RGS2 is significantly increased and ATF4 is reduced, it is expected that by measuring the level of expression or activity of RGS2 and ATF4, the likelihood of lung cancer recurrence can be easily and quickly predicted. In addition, since the present inventors have identified that the growth of slow-cycling cancer cells can be inhibited and the apoptosis thereof can be induced by eliminating the expression of RGS2 or blocking the protein synthesis inhibitory action of RGS2, the present invention is expected to be also variously usable in the drug development of lung cancer recurrence inhibiting therapeutic agents for inhibiting the expression or activity of RGS2.

专利号:WO-2005102340-A1
优先权日:2003-05-30
标题 :Piperazine melanocortin-specific compounds
发明人：SHARMA SHUBH D; SHI YI-QUN; WU ZHIJUN; RAJPUROHIT RAMESH
权利人:PALATIN TECHNOLOGIES INC; SHARMA SHUBH D; SHI YI-QUN; WU ZHIJUN; RAJPUROHIT RAMESH
摘要:Melanocortin receptor-specific piperazine or ketopiperazine compounds having the structure (I); and stereoisomer and pharmaceutically acceptable salts thereof, where X is CH2 or C=O, R1, R2, and R3 are as described in the specification, preferably where R3 is a D-amino acid with at least one substituted or unsubstituted phenyl or naphthyl aromatic ring, and where R3 optionally further includes an amine capping group, a second amino acid residue or a second amino acid residue with an amine capping group, which compounds are agonists, antagonists or mixed agonists and antagonists at one or more melanocortin receptors, and having utility in the treatment of melanocortin receptor-related disorders and conditions. Methods of synthesis of compounds of structure (I), pharmaceutical compositions containing a compound of structure (I) and methods relating to the use thereof are also disclosed.

专利号:CN-113045503-B
优先权日:2020-07-31
标题:Preparation method of 2-trifluoromethyl substituted quinazolinone compound and application of compound in synthesis of drug molecules

专利号:CA-3111403-A1
优先权日:2018-09-17
标 题:Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease

专利号:CN-114108013-A
优先权日:2021-12-31
标 题:A kind of electrochemical synthesis method of trifluoromethyl substituted polycyclic quinazolinone derivatives

专利号:WO-2020061106-A4
优先权日:2018-09-17
标题:Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease