CAS: 615-18-9; 2-Chlorobenzoxazole

该化合物是一种杂交有机化合物,其特点是在2位置用氯原子取代苯氧新诺明核心,该化合物是有机合成的多用途中间体,特别是在生产药品,农用化学品和特殊化学品方面.其反应式氯化混合物能够产生有效的核生殖替代反应,有助于将苯氧新诺明衍生物引入更复杂的结构.该化合物在标准处理条件下表现出稳定性,与一系列溶剂和试剂相容.其定义明确的再活动特征使它成为开发生物活性分子或功能材料的研究人员的宝贵建筑块. 2-氯新诺非新诺明的纯性和一致性对于合成应用的再生效果至关重要.

结构式图片

相似化合物

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ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

  • 合成目标产物 2-Chlorobenzoxazole 主要起始原料 2-Mercaptobenzoxazole
  • (文献来源)合成步骤主要原料 2-Mercaptobenzoxazole
苯并恶唑置于n-氯代丁二酰亚胺,Lithium Tert-Butoxide体系中,用 四氢呋喃 作为反应溶剂,化学反应 0.17H,反应生成 2-氯苯并恶唑
参考文献:N-取代的2-氨基唑衍生物的便捷一锅合成
标题:N-取代的2-氨基唑衍生物的便捷一锅合成
摘要:摘要 描述了一个简单的一锅法合成n-取代的2-氨基唑衍生物的实用方法,该方法采用简单的唑底物,氮亲核试剂,叔丁醇锂为碱,碘来介导碳氮键的形成.该方法在室温下在大气中使用常规台式装置进行,或者可以使用微波辐照方便地进行. 描述了一个简单的一锅法合成n-取代的2-氨基唑衍生物的实用方法,该方法采用简单的唑底物,氮亲核试剂,叔丁醇锂为碱,碘来介导碳氮键的形成.该方法在室温下在大气中使用常规台式装置进行,或者可以使用微波辐照方便地进行.
DOI:10.1055/s-0032-1316868

海关参考信息

专利信息


专利号:US-6159673-A
优先权日:1996-07-17
标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound
发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.

专利号:EP-1473330-B1
优先权日:1996-07-17
标题:Process for the synthesis of oxonol compound
发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.

专利号:US-9549921-B2
优先权日:2013-06-24
标 题:Heterocyclic compounds and methods of use thereof for the treatment of hepatitis C
发明人:HE SHUWEN; LAI ZHONG; DAI XING; XIAO DONG; LONDON CLARE; ZORN NICOLAS; NARGUND RAVI; PALANI ANANDAN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD
权利人:HE SHUWEN; LAI ZHONG; DAI XING; XIAO DONG; LONDON CLARE; ZORN NICOLAS; NARGUND RAVI; PALANI ANANDAN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD; MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.(I)

专利号:US-11976052-B2
优先权日:2019-01-11
标题:Leukotriene synthesis inhibitors
发明人:BURGOYNE DAVID L; DEBRUIN ERIN; FONAREV JULIA; YEE JAMES GEE KEN; LANGLANDS JOHN MICHAEL
权利人:NAEGIS PHARMACEUTICALS INC
摘要:Provided are specific leukotriene synthesis inhibitor compounds and pharmaceutical compositions comprising the compounds and methods of using the compounds and the pharmaceutical compositions in treating, for example, inflammatory diseases or conditions.

专利号:US-2009099200-A1
优先权日:2005-06-09
标题 :Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人:LI CHUN SING; RAMTOHUL YEEMAN K; HUANG ZHENG; LACHANCE NICOLAS
权利人:LI CHUN SING; RAMTOHUL YEEMAN K; HUANG ZHENG; LACHANCE NICOLAS
摘要:Azacyclohexane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:EP-1473330-A1
优先权日:1996-07-17
标题:Process for the synthesis of oxonol compound
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主要参考文献

[参考文献]: J Sam, Et Al. Reaction Of 2-Chlorobenzoxazole With Anthranilic Acids And 2-Amino-1-Naphthalenesulfonic Acid. J Pharm Sci. 1968 Aug;57(8):1445-6.

合成参考文献


摘要:Schnürch, M.; Hämmerle, J.; Stanetty, P., Science of Synthesis Knowledge Updates, (2010) 1, 195.
摘要:Schnürch, M.; Hämmerle, J.; Stanetty, P., Science of Synthesis Knowledge Updates, (2010) 1, 196.
摘要:Schnürch, M.; Hämmerle, J.; Stanetty, P., Science of Synthesis Knowledge Updates, (2010) 1, 196.
摘要:Ye, Z.-S., Science of Synthesis Knowledge Updates, (2021) 2, 407.
摘要:Ye, Z.-S., Science of Synthesis Knowledge Updates, (2021) 2, 386.
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