CAS: 66521-66-2; 4-(Pyridin-3-yl)Pyrimidin-2-Amine

相似化合物

874779-67-6 98589-71-0 866051-26-5

上下游产品

CAS号593-85-1 碳酸胍 | CAS号55314-16-4 1-(3-吡啶基)-3-(二甲... | CAS号3993-78-0 2-氨基-4-氯嘧啶 | CAS号1692-25-7 吡啶-3-硼酸 | CAS号50-01-1 盐酸胍 | CAS号506-93-4 硝酸胍 | CAS号1144477-16-6 N-[4-(pyridin-3... | CAS号420-04-2 氰胺 | CAS号88-74-4 2-硝基苯胺 | CAS号350-03-8 3-乙酰吡啶 | CAS号404844-11-7 N-[4-甲基-3-(4-吡啶... | CAS号917392-54-2 4-甲基-3-[[4-(3-吡... | CAS号641571-10-0 尼罗替尼 | CAS号152459-95-5 伊马替尼

4-(3-吡啶基)-2-氯嘧啶置于ammonium Hydroxide体系中,用 水 作为反应溶剂,化学反应 16.0H,以87%的收率获得产物4-(3-吡啶基)-2-氨基嘧啶
参考文献: Benzimidazole Derivatives As Selective Proteine Kinase Inhibitors[fr] Dérivés De Benzimidazole à Utiliser En Tant Qu'Inhibiteurs Sélectifs De Protéine Kinase
标题: Benzimidazole Derivatives As Selective Proteine Kinase Inhibitors[fr] Dérivés De Benzimidazole à Utiliser En Tant Qu'Inhibiteurs Sélectifs De Protéine Kinase
摘要:本发明涉及式(I)的化合物或其药用可接受的盐.其中n,R1,R2,R3,R4,R5,A,Q和x如描述中所定义.这些化合物选择性地调节,调控和/或抑制信号传导,该信号传导由涉及多种人类和动物疾病的某些天然和/或突变的蛋白激酶介导,如细胞增殖,代谢,过敏和退行性疾病.更具体地说,这些化合物是有效且选择性的天然和/或突变的c-Kit抑制剂.

专利信息

专利号:WO-2013035102-A1
优先权日:2011-09-05
标 题 :Processes for the preparation of imatinib base and intermediates thereof
发明人：KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD; KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
摘要:The invention relates to an improved process for the preparation of highly pure imatinib base (99.99% HPLC purity) of formula (I) and the pharmaceutically acceptable acid addition salts thereof. This invention also relates to processes for the preparation of the intermediates in the synthesis of imatinib base.

专利号:US-2023065387-A1
优先权日:2019-10-14
标题:Synthesis of tyrosine kinase inhibitors

专利号:CN-114315595-B
优先权日:2021-11-30
标题 :Preparation method of a carbon-supported iron-based catalyst and its application in the synthesis of anti-cancer inhibitor intermediates

专利号:US-10738028-B2
优先权日:2016-05-11
标题:Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor
发明人：HU WENHAO; LV FENGPING; TANG YANG; LI ZIYAN; CHEN CHEN; WEI JIANHAI; DONG SUZHEN; QIAN YU
权利人:RUDONG RUIEN PHARMACEUTICAL TECH CO LTD
摘要:Disclosed are the anti-bacterial activity and the anti-tumor activity of a class of new spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor. The spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor of the present invention, as a class of new anti-bacterial agent, are effective against many antibiotic-resistant Gram-positive strains by inhibiting the activity of the peptide deformylase required in the synthesis of bacterial proteins, and do not affect the synthetic process of the main proteins of the human body, thus selectively killing bacteria. The spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor of the present invention, as a class of new anti-bacterial agent, can affect the energy balance of the cancer cells through inhibiting the peptide deformylase of the mitochondria in the cells, so that the mitochondrial membrane is depolarized, ATP is exhausted and cell apoptosis is promoted, and has good inhibitory activities on many cancer cell strains such as colorectal cancer, leukemia, lung cancer, gastric cancer, cervical cancer, breast cancer, prostatic cancer, liver cancer and osteosarcoma at relatively lower concentrations. The structure of exemplary invention spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitors are represented by one or more of:

专利号:WO-2021074138-A1
优先权日:2019-10-14
标题:Synthesis of 6-methyl-n1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

专利号:EP-4045494-B1
优先权日:2019-10-14
标 题 :Synthesis of 6-methyl-n1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
发明人：ABRAHAM RAJKUMAR GURUBATHAM; LIN XIANGLIANG
权利人:ESCO ASTER PTE LTD