CAS: 667-27-6; Ethyl 2-Bromo-2,2-Difluoroacetate

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二氟乙酸乙酯置于copper(Ll) Bromide体系中,用 乙酸乙酯 作为反应溶剂,化学反应生成 二氟溴乙酸乙酯
参考文献:吖啶橙半(氯化锌)盐作为路易斯酸-光氧化还原杂化催化剂用于反应生成 α-羰基自由基
标题:吖啶橙半(氯化锌)盐作为路易斯酸-光氧化还原杂化催化剂用于反应生成 α-羰基自由基
摘要:据报道,一种易于获得的有机-无机杂化催化剂用于α-卤代羰基化合物的还原断裂.稳健的杂化催化剂是 Zncl 2 Lewis 酸和吖啶橙作为光活性有机染料的自稳定组合.已经使用光物理和电化学实验详细研究了这种混合催化剂的机械特性.一项系统的研究使我们能够发现合适的路易斯酸以有效地稳定α-卤代羰基化合物,从而降低标准有机染料范围内的还原电位.该策略通过引导光氧化还原循环通过氧化猝灭途径解决了脱卤氢化或烷基自由基同源偶联等问题.光活性有机染料和路易斯酸对应物之间的协同作用通过有效和受控地反应生成烷基自由基,使功能化与广泛的偶联伙伴成为可能,并作为昂贵的后过渡金属基光催化剂的合适替代品.为了证明这种协同催化体系的应用潜力,研究了四种不同的α-羰基溴的合成转化,具有广泛的底物范围.
DOI:10.1002/adsc.202101053

专利信息

专利号:WO-2006095359-A1
优先权日:2005-03-10
标题:Synthesis of 2-deoxy-2, 2-di fluoro-d-ribo furanose-3, 5 di(4-methy/4-nitro-chloro)benzoate and its conversion to gemcitabine hydrochloride thereof
发明人：POTLURI RAMESH BABU; VENKATA SUBRAMANIAN HARIHARAKR; BETINI RAMESH; GUNTURU SATYANARAYANA
权利人:SMS PHARMACEUTICALS LTD; POTLURI RAMESH BABU; VENKATA SUBRAMANIAN HARIHARAKR; BETINI RAMESH; GUNTURU SATYANARAYANA
摘要:The invention describes the synthesis of hereto unreported 2-deoxy-2,2-difluoro-D-ribofuranose-3,5-di-(aroyl) derivative of formula-Vb, where in R=;CH3,CI,NO2 and its conversion to Gemcitabine HCl of formula-I, an anti cancer product.

专利号:US-9512250-B2
优先权日:2012-02-23
标 题 :Manganese catalyzed photopolymerization of fluorinated monomers
发明人：ASANDEI ALEXANDRU D
权利人:UNIV CONNECTICUT
摘要:The disclosure discloses initiating systems for the radical polymerization of alkenes, and especially fluorine substituted alkenes. The polymerization is catalyzed by a metal carbonyl, preferably manganese carbonyl. The polymerization is initiated directly from alkyl halides at room temperature under visible white light. The polymers also allow the synthesis of block copolymers. The process comprises polymerizing at least one alkene monomer in the presence of a halide radical initiator, carbonyl catalyst and a solvent, under reaction conditions and for a time sufficient to polymerize the at least one alkene monomer to form a polymer. The present disclosure provides a method for living polymerization of alkene monomers which provides a high level of macromolecular control over the polymerization process and which leads to uniform and controllable polymeric products. This disclosure also provides a method for activating any halide (Cl, Br, I) chain ends of such polymers for the synthesis of block copolymerizations.

专利号:US-7084281-B2
优先权日:2003-01-22
标题:Synthesis of dihalohydrins and tri- and tetra-substituted olefins
发明人：FALCK JOHN R; BARMA DEB K; KUNDU ABHIJIT
权利人:UNIV TEXAS
摘要:A novel synthesis reaction for highly stereospecific tri- and tetra-substituted olefins is described. A single stereoisomer of stable α-halo-α,β-ester is produced in high yield by the reaction of aldehyde or ketone with a trihalogenated compound such as trichloroacetate in the presence of CrCl 2 in a solvent. By varying the amount of CrCl 2 used, the stable dihalohydrin intermediate may be obtained as well.

专利号:US-2007042987-A1
优先权日:2004-07-30
标题:Stereoselective synthesis of beta-nucleosides
发明人：LIN KO-CHUNG; LI WENSEN; LIN CHUNHUI; YUNGSHUN WEIN; KUO-HIS KAO
权利人:LIN KO-CHUNG; LI WENSEN; LIN CHUNHUI; YUNGSHUN WEIN; KUO-HIS KAO
摘要:This invention relates to a process of stereoselectively synthesizing an alcohol of the following formula: n n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined in the specification. The process includes reacting (R) 4-formyl-2,2-dimethyldioxolane with α-bromoacetate in the presence of Zn and a Zn activating agent.

专利号:US-7485716-B2
优先权日:2005-05-02
标题:Stereoselective synthesis of β-nucleosides
发明人：LIN KO-CHUNG; LI WENSEN
权利人:PHARMAESSENTIA CORP
摘要:This invention relates to a process for stereoselectively preparing a nucleoside of the following formula: n nwherein R 3 , R 4 , and B are defined herein. The process includes reacting a furanose compound with a nucleobase in the presence of a halide salt. Also disclosed is another process for stereoselectively synthesizing an intermediate that can be used to make the starting compound in the first-mentioned process.

专利号:US-12435034-B2
优先权日:2020-10-19
标 题 :Process of preparing 3-fluoro-5(((1R,2AR)-3,3,4,4-tetrafluoro-1,2A-dihydroxy-2,2A,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)-oxy)benzonitrile
发明人：FU JIPING; LOU YAN; HE YIGANG; SHI YUETAO; ZHOU PENG; LI XINGXING
权利人:NIKANG THERAPEUTICS INC
摘要:Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.