CAS: 69-93-2; 1H-Purine-2,6,8(3H,7H,9H)-Trione

该化合物是一种氮化合物,在人类和许多其他生物的纯净新陈代谢中起着关键作用;是一种白色,无味,晶状物质,在水中可略溶,在碱溶液中可溶性较易溶;铀酸具有分子式C5H4N4O3, 摩尔质量约为168.11克/摩尔;主要产自肝脏,通过肾脏排出,成为核糖酸分解的废物;在生理条件下,硫酸主要存在于其厌离形式 ----尿 --中,它可能在联合和组织中沉淀,导致甲状腺等条件;铀酸还具有抗氧化性特性,有助于身体防范氧化性压力;其水平可能受到饮食,水分和某些医学条件的影响,使其在临床环境中成为重要的生物标记.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

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CAS号68-94-0 次黄嘌呤 | CAS号69-89-6 黄嘌呤 | CAS号57-13-6 尿素 | CAS号72553-23-2 (2-amino-6-oxo-... | CAS号3240-72-0 5,6-氨基-2,4(1H,3... | CAS号73-24-5 腺嘌呤 | CAS号73-40-5 鸟嘌呤 | CAS号80156-61-2 N-(guanin-8-yl)... | CAS号69-93-2 尿酸 | CAS号58-61-7 腺苷 | CAS号120-89-8 仲班酸 | CAS号5676-27-7 Oxalyldiurea | CAS号105245-87-2 N-(2,5-氢-2,5-二氧... | CAS号97-59-6 尿囊素 | CAS号55441-71-9 9-甲基尿酸 | CAS号605-99-2 3-甲基尿酸-d3 | CAS号2002-60-0 1H-Purine-2,8(3... | CAS号2577-38-0 2,4,7(1H,3H,8H)... | CAS号5807-13-6 Bisalloxazine | CAS号27038-96-6 1H-Purine-2,6-d...

合成工艺路线路线简述

    Uric Acid置于维生素 C体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应生成 尿酸
    参考文献:十六烷基三甲基溴化铵-聚苯胺/活性炭复合物在高浓度抗坏血酸存在下同时测定多巴胺和尿酸
    标题:十六烷基三甲基溴化铵-聚苯胺/活性炭复合物在高浓度抗坏血酸存在下同时测定多巴胺和尿酸
    摘要:我们描述了一种由十六烷基三甲基溴化铵(ctab)官能化的聚苯胺(pani)和活性炭(ctab-Pani / Ac)组成的简单,低成本且可大量生产的复合物,用于同时测定多巴胺(da)和尿酸.
    DOI:10.1039/c6Ra18740D

    专利信息


    专利号:US-7122304-B2
    优先权日:1997-05-12
    标 题:Methods for the storage and synthesis of nucleic acids using a solid support
    发明人:GOLDSBOROUGH MINDY D; FOX DONNA K
    权利人:WHATMAN INC
    摘要:The invention relates to storage of nucleic acid (particularly mRNA) on a solid support and to using such nucleic acid in nucleic acid synthesis or amplification reactions. In a preferred aspect, the invention provides synthesis of cDNA and cDNA libraries.

    专利号:US-2021246476-A1
    优先权日:2020-01-31
    标 题:Biosynthesis of preparing nicotinamide mononucleotide and derivatives thereof
    发明人:ZHANG YI HENG PERCIVAL
    权利人:ZHANG YI HENG PERCIVAL
    摘要:A method of making nicotinamide mononucleotide (NMN), nicotinamide mononucleotide derivatives, or mixtures thereof is disclosed. The method involves the in vitro artificial enzymatic pathways comprised: the generation of alpha-D-ribose-1-phosphate from numerous substrates followed by the synthesis of nicotinamide mononucleotide catalyzed by nicotinamide riboside phosphorylase and nicotinamide riboside kinase or the generation of 5-phospho-alpha-D-ribose-1-diphosphate from nucleotides followed by the synthesis of nicotinamide mononucleotide catalyzed by nicotinamide phosphoribosyltransferase. The multiple enzymes were reconstituted in one pot, wherein in-situ removal of byproducts that can be converted to other non-inhibitory chemicals with supplementary enzymes push the overall biotransformation toward the synthesis of nicotinamide mononucleotide. Furthermore, nicotinamide mononucleotide can be converted to its derivatives—nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate.

    专利号:US-2003050305-A1
    优先权日:2000-05-22
    标题:Thromboxane inhibitors, compositions and methods of use
    发明人:TEJADA INIGO SAENZ DE
    摘要:The present invention describes methods for treating or preventing sexual dysfunctions in males and females, and for enhancing sexual responses in males and females by administering a therapeutically effective amount of at least one thromboxane inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The male or female may preferably be diabetic. The present invention also provides novel compositions comprising at least one thromboxane inhibitor, and, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and, optionally, at least one therapeutic agent, such as, vasoactive agents, nonsteroidal antiinflanmmatory compounds (NSAIDs), selective cyclooxygenase-2 (COX-2) inhibitors, anticoagulants, angiotensin converting enzymes (ACE) inhibitors, angiotensin II receptor antagonists, renin inhibitors, and mixtures thereof. The present invention also provides methods for treating or preventing ischemic heart disorders, myocardial infarction, angina pectoris, stroke, migraine, cerebral hemorrhage, cardiac fatalities, transient ischaemic attacks, complications following organ transplants, coronary artery bypasses, angioplasty, endarterectomy, atherosclerosis, pulmonary embolism, bronchial asthma, bronchitis, pneumonia, circulatory shock of various organs, nephritis, graft rejection, cancerous metastases, pregnancy-induced hypertension, preeclampsia, eclampsia, thrombotic and thromboembolic disorders, intrauterine growth, gastrointestinal disorders, renal diseases and disorders, disorders resulting from elevated uric acid levels and dysmenorrhea, and for inhibiting platelet aggregation or platelet adhesion or relaxing smooth muscles.

    专利号:EP-1548006-B1
    优先权日:2003-12-12
    标题 :Synthesis of tetraazapentamethine derivatives, keratin fibers dyeing process which uses such synthesis
    发明人:PEREIRA RUI; BURGAUD HERVE
    权利人:OREAL
    摘要:Producing tetraazapentamethine compounds (I) comprising reacting an azine compound with an oxidizing agent, is new. Producing tetraazapentamethine compounds of formula (I) comprises reacting an azine compound of formula (VI) or (VII) with an oxidizing agent; [Image] [Image] W1a cationic heteroaromatic group of formula (II) or (III); W2a heteroaromatic group of formula (IV) or (V); Z14Z7 or Z1; Z15Z8 or Z2; Z16Z13 or Z0; R25R5 or R1; Z17Z9 or Z3; Z18Z10 or Z4; Z19Z11 or Z5; Z20Z12 or Z6; R26R8 or R3; R27R7 or R4; R28, R29H, 1-6C alkyl or 1-6C alkoxy, but not both H; Z0CR2, N or NR21; Z1O, S or NR9; Z2N or CR10; Z3N or CR11; Z4N or CR12; Z5N or CR13; Z5N or CR13; Z6N or CR14; Z7O, S or NR15; Z8N or CR16; Z9N or CR17; Z10N or CR18; Z11N or CR19; Z12N or CR20; Z13CR6, N or NR22; R2, R6, R10, R16H; 1-4C alkyl substituted with 0-3 of OH, 1-2C alkoxy, 2-4C (poly)hydroxyalkoxy, NH2, 1-2C (di)alkylamino, COOH or SO3H; phenyl substituted with 0-2 of OH, 1-2C alkoxy, 2-4C (poly)hydroxyalkoxy, NH2, 1-2C (di)alkylamino; COOH; sulfonylamino; R1, R4, R5, R7, R9, R15, R21, R221-6C alkyl substituted with 0-3 of OH, 1-2C alkoxy, 2-4C (poly)hydroxyalkoxy, NH2, 1-2C (di)alkylamino, COOH or SO3H; R0, R3, R8, R11-R14, R17-R20H; 1-6C linear or branched hydrocarbyl with 0-3 unsaturations, optionally substituted with 1-3 of OH, 1-2C alkoxy, 2-4C (poly)hydroxyalkoxy, NH2, 1-2C (di)alkylamino, COOH, SO3H, sulfonylamino, 2-4C (poly)hydroxyalkylamino or halo and optionally interrupted by O, N, S or SO2; phenyl optionally substituted with 1-3 of OH, 1-2C alkoxy, 2-4C (poly)hydroxyalkoxy, NH2, 1-2C (di)alkylamino, COOH, SO3H, sulfonylamino, 2-4C (poly)hydroxyalkylamino or halo; pyrazolyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, triazolyl, pyridyl, pyrimidinyl, triazinyl, pyrazinyl or pyridazinyl; X : an anion; R2+R10, R11+R12, R6+R16, R17+R18 can form a 5-6C aromatic ring substituted with 0-2 of OH, NH2, 1-2C (di)alkylamino, 1-2C alkoxy, 2-4C (poly)hydroxyalkylamino. An independent claim is also included for dyeing keratinic fibers by applying (VI) or (VII) onto the wet or dry fibers in the presence of an oxidizing agent. [Image].

    专利号:US-7288120-B2
    优先权日:2003-12-12
    标题 :Synthesis of tetraazapentamethine compounds, and processes for dyeing keratin fibers using this synthesis
    发明人:PEREIRA RUI; BURGAUD HERVE
    权利人:OREAL
    摘要:The present disclosure relates to processes for synthesizing tetraazapentamethine compounds that comprise reacting at least one compound of azine type with at least one oxidizing agent. The disclosure also relates to processes for dyeing keratin fibers, for example human keratin fibers, that comprise using such synthetic processes.

    专利号:US-5872124-A
    优先权日:1996-07-31
    标题 :Treatment of diseases of the central nervous system using uric acid as a scavenger of peroxynitrite
    发明人:KOPROWSKI HILARY; HOOPER DOUGLAS CRAIG; FARBER JOHN L
    权利人:UNIV JEFFERSON
    摘要:The process of treating a disease of the central nervous system with an agent from one or more of the following three classes of agents: (1) nitric oxide scavengers, (2) peroxynitrite scavengers, and (3) agents that either interfere with the synthesis of iNOS in the cell or the enzymatic activity of iNOS in the cell.
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    主要参考文献

    [参考文献]: Wang Q, Et Al. Recent Progress On Uric Acid Detection: A Review. Crit Rev Anal Chem. 2020;50(4):359-375.
    [参考文献]: Yasutake Y, Et Al. Uric Acid Ameliorates Indomethacin-Induced Enteropathy In Mice Through Its Antioxidant Activity. J Gastroenterol Hepatol. 2017 Nov;32(11):1839-1845.
    [参考文献]: Angélica T Vieira, Et Al. A Role For Gut Microbiota And The Metabolite-Sensing Receptor Gpr43 In A Murine Model Of Gout. Arthritis Rheumatol. 2015 Jun;67(6):1646-56.
    [参考文献]: Antoine Sadiki Kishabongo, Et Al. Glycation Of Nail Proteins: From Basic Biochemical Findings To A Representative Marker For Diabetic Glycation-Associated Target Organ Damage. Plos One. 2015 Mar 17;10(3):E0120112.
    [参考文献]: Atallah F Ahmed, Et Al. Hepatorenal Protective Effect Of Antistax() Against Chemically-Induced Toxicity. Pharmacogn Mag. 2015 May;11(Suppl 1):S173-81.

    合成参考文献


    参考文献:10.1007/s00709-010-0110-3
    摘要:Millaku A, Leser V, Drobne D, Godec M, Torkar M, Jenko M, Milani M, Tatti F. Surface characteristics of isopod digestive gland epithelium studied by SEM. Protoplasma. 2010 May;241(1-4):83–9. doi: 10.1007/s00709-010-0110-3.
    参考文献:10.1007/s00296-010-1373-x
    摘要:Yang Z, Liang Y, Xi W, Zhu Y, Li C, Zhong R. Association of serum uric acid with lupus nephritis in systemic lupus erythematosus. Rheumatology International. 2010 Feb 14;31(6):743–8. doi: 10.1007/s00296-010-1373-x.
    参考文献:10.1186/2047-783x-14-s4-49
    摘要:Cofta S, Wysocka E, Michalak S, Piorunek T, Batura-Gabryel H, Torlinski L. Endothelium-derived markers and antioxidant status in the blood of obstructive sleep apnea males. European Journal of Medical Research. 2009 Dec 07;14(Suppl 4):49. doi: 10.1186/2047-783x-14-s4-49.
    参考文献:10.1186/2047-783x-14-s4-255
    摘要:Wysocka E, Cofta S, Dziegielewska S, Gozdzik J, Torlinski L, Batura-Gabryel H. Adipocytokines in sleep apnea syndrome. European Journal of Medical Research. 2009 Dec 07;14(Suppl 4):255. doi: 10.1186/2047-783x-14-s4-255.
    参考文献:10.4110/in.2009.9.5.192
    摘要:Lee JS, Yang CS, Shin DM, Yuk JM, Son JW, Jo EK. Nitric Oxide Synthesis is Modulated by 1,25-Dihydroxyvitamin D3 and Interferon-gamma in Human Macrophages after Mycobacterial Infection. Immune Netw. 2009 Oct;9(5):192–202.
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