CAS: 92-78-4; N-(4-Chlorophenyl)-3-Hydroxy-2-Naphthamide

• 英文名称N-(4-Chlorophenyl)-3-Hydroxy-2-Naphthamide
• 中文名称色酚 AS-E
• IUPAC名称N-(4-chlorophenyl)-3-hydroxy-2-naphthamide
• 其它别名4'-Chloro-3-hydroxy-2-naphthanilide; C.I. Azoic Coupling Component 10
• CAS编号92-78-4
• MFCD编号:MFCD00021639
• EINECS号:202-189-7
• FDA UNII编号:8V561WAE43
• 分子式:C17H12ClNO2
• 分子量:297.74
• 产品CID: 1966442
• 产品分类染料及颜料 → 染料 → 冰染染料(显色染料)

• 相似结构搜索
• InChIKey: OHAXNCGNVGGWSO-UHFFFAOYSA-N
• InChI=1S/C17H12ClNO2/c18-13-5-7-14(8-6-13)19-17(21)15-9-11-3-1-2-4-12(11)10-16(15)20/h1-10,20H,(H,19,21)…
• 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数2.0

物理性质

• 熔点255°C
• 沸点416.5±30.0 °C(预测)
• 闪点205.7 °C
• 密度1.399±0.06 g/cm3(预测)
• pKa:8.69±0.40(预测)
• PSA:49.33
• LogP:2.97 at 23°C and pH7.2
• 折射率1.735
• 蒸汽压0Pa at 25°C
• 溶解性Soluble In Dimethylformamide
• 外观形态白色至淡黄色至深绿色米色固体
• 储存条件密封, 常温干燥保存
• 产品应用主要用作棉织物染色和印花打底剂,也可作有机颜料的中间体.用作棉纤维染色和印花的打底剂,也可用作色淀颜料的中间体.
• 性质描述该品呈淡米色粉状,熔点为258-259°C.可溶于邻二氯苯,不溶于水和碳酸钠溶液.在氢氧化钠溶液中呈黄色.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别严重眼刺激 类别2
  皮肤致敏 类别1B
  水生慢性毒性 类别2
• 警示词Warning(警告)
• 危险描述H319 |造成严重眼刺激.
  H317 |可能引起皮肤过敏反应.
  H411 |对水生生物有毒并具有长期持续影响.
• 防范说明P261-P264-P272-P280-P302+P352-P305+P351+P338
• UN编号25kgs
• 危险品标志Xn
• 安全声明S24/25,S36,S7
• 危险类别码R42/43
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 Naphthol As-E 主要起始原料 4-Chloroaniline And 3-Hydroxy-2-Naphthoic Acid
• 92-70-6 = 92-78-4
  反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene; Rt -> 10 °C; 10 °C; 15 Min,135 °C
  标题:Synthesis Of Naphthol As-X Chloroacetates And Study On The Electron Effects On The Human Leukocyte Esterase Staining
  作者:Tran,Van Tinh; Pham,Hoai Thu; Nguyen,Anh Tri; Luu,Van Boi
  参考文献:Tap Chi Hoa Hoc 日期:2011 卷标:49(4) 页码:479-488]
  
  92-70-6 = 92-78-4
  反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Chlorobenzene; Rt; Rt -> 130 °C; 25 Min,130 °C
  标题:Preparation And Biological Properties Of Ring-Substituted 3-Hydroxynaphthalene-2-Carboxanilides
  作者:Kos,Jiri; Zadrazilova,Iveta; Pesko,Matus; Pavlica,Jiri; Gonec,Tomas; Et Al
  参考文献:International Electronic Conference On Synthetic Organic Chemistry 日期:2012]
  
  = 92-78-4 [标题:Reaction Conditions
  标题:Production Method And Apparatus Of Naphthol As Series Products
  参考文献:China]
  
  = 92-78-4 [标题:Reaction Conditions
  标题:Design,Synthesis,And Biological Evaluation Of Conformationally Constrained Analogues Of Naphthol As-E As Inhibitors Of Creb-Mediated Gene Transcription
  作者:Jiang,Min; Li,Bingbing X.; Xie,Fuchun; Delaney,Frances; Xiao,Xiangshu
  参考文献:Journal Of Medicinal Chemistry 日期:2012 卷标:55(8) 页码:4020-4024]
  
  = 92-78-4 [标题:Reaction Conditions
  标题:Benzamide,Naphthalenecarboxamide,Arylacetamide,Arenesulfonamide,Carbamate,Thiocarbamate,And Benzylamine Inhibitors Of Inosine-5'-Monophosphate Dehydrogenase
  参考文献:World Intellectual Property Organization]
  
  92-70-6 = 92-78-4
  反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene; Rt; 10 Min,100 °C; 15 Min,120 °C; 20 Min,130 °C
  标题:Antibacterial And Herbicidal Activity Of Ring-Substituted 3-Hydroxynaphthalene-2-Carboxanilides
  作者:Kos,Jiri; Zadrazilova,Iveta; Pesko,Matus; Keltosova,Stanislava; Tengler,Jan; Et Al
  参考文献:Molecules 日期:2013 卷标:18 页码:7977-7997]
  
  92-70-6 = 92-78-4
  反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene; 10 Min,100 °C; 15 Min,120 °C; 20 Min,130 °C
  标题:3-Hydroxynaphthalene-2-Carboxanilides And Their Antitrypanosomal Activity
  作者:Kos,Jiri; Kapustikova,Iva; Clements,Carol; Gray,Alexander I.; Jampilek,Josef
  参考文献:Monatshefte Fuer Chemie 日期:2018 卷标:149(5) 页码:887-892]
  
  92-70-6 = 92-78-4
  反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dimethylformamide,Chlorobenzene; 1.5 H,35 - 40 °C1.2 Reagents: Sodium Acetate Solvents: Dimethylformamide; 0.5 H,5 - 10 °C; 3 H,20 °C; 20 °C -> 50 °C
  标题:Synthesis And β-Adrenergic Blocking Activity Of Naphthyloxypropylamines
  作者:Vattipalli,Ramya; Shirodkar,Prabhakar Y.; Somani,Rakesh R.; Kadam,Vilasrao J.
  参考文献:Indian Journal Of Chemistry 日期:2008 卷标:(10) 页码:1587-1590]
  
  = 92-78-4 [标题:Reaction Conditions
  标题:Preparation Of 3-Hydroxy-2-Naphthoic Anilides
  参考文献:Germany]
  
  = 92-78-4 [标题:Reaction Conditions
  标题:N-Substituted Amides Of 3-Hydroxy-2-Naphthalenecarboxylic Acid
  参考文献:Poland

海关参考信息

• 2902902000-精萘
  2903919090-氯苯
  2912110000-甲醛
  2912210000-苯甲醛
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

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