CAS: 100306-34-1; (S)-3-Chloro-1-Phenylpropan-1-Ol

相似化合物

18776-12-0 100306-33-0 936-59-4

上下游产品

CAS号936-59-4 3-氯代苯丙酮 | CAS号18776-12-0 3-氯-1-苯基丙醇 | CAS号293322-40-4 3-Cloro-1-pheny... | CAS号147199-40-4 达泊西汀杂质3 | CAS号82248-59-7 盐酸托莫西汀 | CAS号130194-43-3 (S)-3-苯基-3-(4-三... | CAS号114133-37-8 (S)-3-(甲基氨基)-1-苯基丙醇 | CAS号114247-09-5 R-氟西汀 | CAS号114446-47-8 (R)-3-Chloro-1-... | CAS号873436-53-4 (1S)-3-(Dimethy...

3-氯-1-苯基丙醇置于吡啶,4-二甲氨基吡啶,Phosphate Buffer,Novozyme 435体系中,用 二氯甲烷 用作溶剂,化学反应 288.0H,反应生成(S)-(-)-3-氯-1-苯基-1-丙醇
参考文献:Chemoenzymatic Synthesis Of The Non-Tricyclic Antidepressants Fluoxetine,Tomoxetine And Nisoxetine
标题:Chemoenzymatic Synthesis Of The Non-Tricyclic Antidepressants Fluoxetine,Tomoxetine And Nisoxetine
摘要:使用来自南极念珠菌的脂肪酶b,通过酯交换和水解分别对3-氯-1-苯基丙醇及其相应的丁酸酯--3-氯-1-苯基-1-丙基丁酸酯进行了动力学拆分.得到的立体构建单元(S)-和(R)-3-氯-1-苯基丙醇被转化为抗抑郁药物氟西汀,托莫西汀和尼索西汀的两种对映体.
Doi:10.1039/b000846J

专利信息

专利号:US-6162949-A
优先权日:1994-12-16
标 题 :Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers
发明人：GATTUSO MARK J
权利人:UOP LLC
摘要:Improved processes for preparation of the (S)-oxetines in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic precursor early in the oxetine synthesis. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer may be racemized and recycled to the resolution phase to avoid loss.

专利号:US-2008004470-A1
优先权日:2004-09-27
标 题:Synthesis of Atomoxetine Hydrochloride
发明人：MATHAD VIJAYAVITTHAL T; GHANTA MAHESH R; GOVINDAN SHANMUGAM; MACHARLA PRABHAKAR; NALIVELA VENU
权利人:MATHAD VIJAYAVITTHAL T; GHANTA MAHESH R; GOVINDAN SHANMUGAM; MACHARLA PRABHAKAR; NALIVELA VENU
摘要:(±)-Atomoxetine oxalate having crystalline Form II and a solid (±)-atomoxetine free base are useful in preparing atomoxetine hydrochloride.

专利号:WO-2008062473-A1
优先权日:2006-10-31
标 题 :Process for preparing atomoxetine hydrochloride
发明人：PATEL VIPUL KANTIBHAI; KUMAR RAJIV; DHAR DWIVEDI SHRIPRAKASH
权利人:CADILA HEALTHCARE LTD; PATEL VIPUL KANTIBHAI; KUMAR RAJIV; DHAR DWIVEDI SHRIPRAKASH
摘要:The present invention relates to the process for preparing Atomoxetine hydrochloride which is a selective norepinephrine reuptake inhibitor. Atomoxetine HCl is chemically known as (-)-iV-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride and represented by formula (I). More particularly, the invention relates to crystalline form of N-methyl-3-phenyl-3-(o- tolyloxy) propylamine oxalate (here in after referred as '(±) Atomoxetine Oxalate'), which is an useful intermediate for the synthesis of Atomoxetine hydrochloride.

专利号:US-5889186-A
优先权日:1994-12-16
标 题:Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers
发明人：GATTUSO MARK J
权利人:UOP INC
摘要:Improved processes for preparation of the (S)-oxetines in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic precursor early in the oxetine synthesis. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer may be racemized and recycled to the resolution phase to avoid undesired losses.

专利号:US-6458955-B1
优先权日:1994-12-16
标 题 :Process for preparation of pharmaceutically desired enantiomers
发明人：GATTUSO MARK J
权利人:UOP LLC
摘要:Improved processes for preparation of high enantiomeric purity compounds center on resolution using simulated moving bed chromatography of a racemic precursor early in the synthesis. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer is racemized and recycled to the resolution phase to avoid loss.

专利号:WO-2006037055-A1
优先权日:2004-09-27
标题 :Synthesis of atomoxetine hydrochloride