CAS: 104146-10-3; (6R,7R)-4-Methoxybenzyl 3-(Chloromethyl)-8-Oxo-7-(2-Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate

相似化合物

113479-65-5 79349-53-4 104146-10-3

上下游产品

4-methoxybenzyl-7-amino-3-chloromethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]°Ct-2-ene-2-carboxylate hydr°Chloride phenylacetyl chloride -3-(phenylacetamido)-4-(phenylsulfonylthio)-2-azetidinone1-2-chloromethyl-1-(p-methoxybenzyloxycarbonyl)-2-propen-1-yl-3-(phenylacetamido)-4-(phenylsulfonylthio)-2-azetidinone p-methoxybenzyl chloride(6R,7R)-3-Methyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester (2R,6R,7R)-3-Methylene-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]°Ctane-2-carboxylic acid 4-methoxy-benzyl ester (6R,7R)-8-Oxo-7-phenylacetylamino-3-(4-trifluoromethyl-benzyl)-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 52H48N4O10S2C52H48N4O10S2

1-<2-Chloromethyl-1-(P-Methoxybenzyloxycarbonyl)-2-Propen-1-Yl>-3-(Phenylacetamido)-4-(Phenylsulfonylthio)-2-Azetidinone置于sodium Methylate体系中,用 甲醇 用作溶剂,化学反应 0.5H,以76.3%的收率获得7-苯乙酰氨基-3-氯甲基-4-头孢烷酸对甲氧基苄酯
参考文献:7-苯乙酰胺-3-氯甲基头孢烷酸对甲氧基苄酯 的制备
标题:7-苯乙酰胺-3-氯甲基头孢烷酸对甲氧基苄酯 的制备
摘要:本发明属于头孢菌素类药物中间体合成领域,公开了7‑苯乙酰胺‑3‑氯甲基头孢烷酸对甲氧基苄酯(简称gcle)的制备方法,本发明以青霉素g钾盐为初始原料,首先与对甲氧基苄氯反应,过氧乙酸氧化,制得青霉素亚砜酯,青霉素亚砜酯先与2‑巯基苯并噻唑反应,再与苯亚磺酸作用得开环物,开环物和氯气作用,在甲醇溶剂下,用甲醇钠闭环,得到7‑苯乙酰胺‑3‑氯甲基头孢烷酸对甲氧基苄酯,本发明溶剂简单易回收,反应条件温和,操作简便,易于工业化生产.

专利信息

专利号:US-9404139-B2
优先权日:2012-01-10
标题:Mutated cephalosporin hydroxylase and its application in deacetylcephalosporanic acid synthesis
发明人：DURAIRAAJ MICHEAL; THIRUMOORTHY RAMANAN; MISHRA KANHU CHARAN; CHINNATHAMBI THANGADURAI; KRISHNAN CAVERY MANIAN; RAJASEKARAN PADMA; SUBRAMANI SUGUMAR; SELVARAJ KAVITHA DAFFROSE; BALAKRISHNAN NATARAJ; RAVIKUMAR CHAKRAVARTHY SATHISH; NATRAJAN MADHIYAZHAGAN ARULMOZHI
权利人:ORCHID CHEMICALS & PHARMACEUTICALS LTD
摘要:A mutant hydroxylase with increased activity and greater substrate specificity towards phenylacetyl-7-ADCA derivatives for the production of phenylacetyl-7-HACA derivatives, which carries one or more amino acid modification at residue positions when compared with certain wild type hydroxylase from certain groups of residues. Also disclosed is a process for the preparation of deacetyl cephalosporanic acid from the corresponding deacetoxy cephalosporanic acid that includes an enzyme of the present invention. Also provided is a method for the production and processing of such enzymes.

专利号:WO-2010082108-A1
优先权日:2009-01-16
标题:Improved process for preparation of key intermediate of cephalosporins
发明人：SAHOO PRABHAT KUMAR; SHRIVASTAVA AJAY KUMAR; YADAV CHHANNU LAL; CHAUBEY BIPIN KUMAR
权利人:NECTAR LIFESCIENCES LTD; SAHOO PRABHAT KUMAR; SHRIVASTAVA AJAY KUMAR; YADAV CHHANNU LAL; CHAUBEY BIPIN KUMAR
摘要:An improved process for the preparation of 7-phenylacetamido-3-vinyl cephalosporanic acid-p-methoxybenzyl ester of formula (I), which is a key intermediate of cephalosporin antibiotics and is extremely useful in their synthesis, is provided. More particularly, an improved process for the preparation of a compound of formula (I) by using a compound of formula (A) is provided, wherein, R represents hydrogen, alkyl, aryl or arylalkyl, which may be same or different and may be further substituted, making it a substantially cost effective and eco-friendly procedure.

专利号:CN-102875576-A
优先权日:2012-10-31
标 题:Synthesis of an antibiotic ceftazidime, ceftazidime for injection and preparation method thereof

专利号:CN-104364376-B
优先权日:2012-01-10
标题 :The cynnematin hydroxylase of mutation and its application in the acid synthesis of deacetylation cephalosporium alkyl

专利号:LU-503177-B1
优先权日:2022-12-12
标题:Preparation method for enzymatic synthesis of cefprozil

专利号:CN-105130868-A
优先权日:2015-07-28
标题 :Improved technology for synthesis of GCLE intermediate