专利号:US-11512097-B2 优先权日:2019-11-25 标题 :Heterocyclic compounds as Delta-5 desaturase inhibitors and methods of use 发明人:ALLEN JENNIFER R; BELTRANI MICHELA; BOURBEAU MATTHEW P; DAMYANOVA TEODORA P; LINGARD IAIN; MINATTI ANA E; VINCETTI PAOLO 权利人:AMGEN INC 摘要:The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5Dâ€?). The compounds have a general Formula I n nwherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.
专利号:US-3558614-A 优先权日:1967-09-05 标题:Synthesis of tetranuclear dyes 发明人:JENKINS PHILIP W 权利人:EASTMAN KODAK CO 摘要:TETRANUCLEAR DYES DERIVED FROM A 2-IMIDAZOLIN-4-ONE, A 2-IMIDAZOLIN-4-THIONE AND A 2-IMIDAZOLIN-4-SELENONE ARE PREPARED IN GOOD YIELDS BY CONDENSING A QUATERNIZED MEROCYANINE DYE DERIVED FROM A 2-IMIDAZOLIN-4-ONE, A 2-IMIDAZOLIN-4-THIONE OR A 2-IMIDAZOLIN4-SELENONE WITH (1) A DIALKOXYALKYL ESTER OF AN ORGANIC ACID, (2) A TRIALKOXY ALKANE OR ARYL COMPOUND, (3) A 3,3-DIALKOZY-1ALKOXYPROPENE, (4) A 1-ANILINO-5-PHENYLIMINO-1,3-PENTADIENE OR (5) A SECOND QUATERNIZED MROCYANINE DYE DERIVED FROM A 2-IMIDAZOLIN-4-ONE, A 2-IMIDAZOLIN-4THIONE OR A 2-IMIDAZOLIN-4-SELENONE, EACH HAVING SUBSTITUTED ON THE CARBON IN THE 2-POSITION A GROUP SUCH AS A B-ACETANILIDOVINYL GROUP, A 4-ACETANILIDO-1,3-BUTADIENYL GROUP, AND A 6-ACETANILIDO-1,3,5-HEXADIENYL GROUP.
专利号:US-9175026-B2 优先权日:2011-03-23 标题:Synthesis of thioether containing trialkoxysilanes 发明人:GARRELL ROBIN L; TUCKER-SCHWARTZ ALEXANDER K 权利人:GARRELL ROBIN L; TUCKER-SCHWARTZ ALEXANDER K; UNIV CALIFORNIA 摘要:The invention relates to a radical-initiated thiol-ene or thiol-yne “clickâ€? reaction that provides a simple and efficient route to diverse trialkoxysilanes. Trialkoxysilanes made in this way are obtained in quantitative to near-quantitative yields with high purity without any or minimal purification. A wide range of functional groups is tolerated in this approach, and even complex alkenes click with the silane precursors. The modular nature of these radical-based thiol-ene or thiol-yne “clickâ€? reactions allows a wide variety of pendant groups to be coupled to silane compounds that can then be coupled to a wide variety surfaces in order to modify their material properties. Consequently, such radical initiated thiol-ene and thiol-yne reactions provide facile and efficient methods for preparing an enormous number of surface-active functional trialkoxysilanes.
专利号:US-2024050916-A1 优先权日:2020-12-14 标题:Biodegradable microcapsules based on composite material and synthesis process 发明人:VRHUNEC ALJOSA; STEFANEC DEJAN; KOTNIK TOMAZ; KRANJC DOMEN 权利人:MIKROCAPS D O O 摘要:The present invention relates to biodegradable microcapsules with a membrane formed of a biodegradable composite material and their synthesis. Biodegradable microcapsules obtained as described in the present invention consist of a core material comprising at least one liquid water-immiscible active component, and a membrane that encloses this core material, the membrane consisting of a composite material comprising a carrier polymer framework and at least one filler deposited into the pores of said carrier polymer framework and deposited onto the surface of said carrier polymer framework, wherein the carrier polymer framework is made of at least one polymer and the filler is a lipophilic biodegradable organic compound which is solid at room temperature and has a melting point above 40° C. The thickness of the membrane is between 20 and 200 nm and the microcapsule diameter is between 1 and 50 pm. Biodegradable microcapsules as described in the present invention are used in the form of aqueous dispersions as additives to fabric softeners, detergents, pesticides, pharmaceutical ingredients, paints, cosmetics products and the like.
专利号:US-2025222420-A1 优先权日:2022-03-15 标题:Biodegradable microcapsules based on crystalline materials and synthesis process 发明人:STEFANEC DEJAN; VRHUNEC ALJOSA; KRANJC DOMEN 权利人:MIKROCAPS D O O 摘要:The present invention relates to a water dispersion of biodegradable microcapsules, with a membrane formed of a biodegradable crystalline material only, i.e. free of polymer framework, and synthesis thereof. Biodegradable microcapsules consist of a core material comprising at least one water-immiscible and water-insoluble active component, and a membrane that encloses this core material, the membrane consisting of a highly crystalline material only, wherein the crystalline material is a lipophilic biodegradable organic compound which is solid at room temperature and has a melting point equal to or above 40° C. Biodegradable microcapsules are in the form of aqueous dispersions and are used primarily for encapsulation of pesticides for use in pest control applications.
专利号:WO-2016110822-A1 优先权日:2015-01-09 标题 :Carboxylic biacyl creatine derivative, uses and method of synthesis thereof 发明人:GARBATI PATRIZIA; MILLO ENRICO; BALESTRINO MAURIZIO; SALIS ANNALISA; ADRIANO ENRICO; DAMONTE GIANLUCA 权利人:UNIV DEGLI STUDI GENOVA 摘要:The invention relates to a novel creatine derivative, the carboxylic biacyl creatine derivative of formula (I) and pharmaceutically acceptable salts thereof, methods of synthesis and the use thereof in the treatment of pathologies due to deficiency of cerebral creatine, such as creatine transporter deficiency, AGAT enzyme deficiency and GAMT enzyme deficiency.
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