CAS: 114873-13-1; Boc-D-Phe(3,4-Cl2)-Oh

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80741-39-5 177966-59-5 177966-58-4

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tert-butyl dicarbonatedi-tert-butyl dicarbonate 2-amino-3-(3,4-dichlorophenyl)propionic acid(S)-3-(3,4-Dichloro-phenyl)-2-ethylamino-propionamide ({[(S)-1-Carbamoyl-2-(3,4-dichloro-phenyl)-ethyl]-ethyl-carbamoyl}-methyl)-carbamic acid tert-butyl ester [(S)-1-{(R)-1-[({[(S)-1-Carbamoyl-2-(3,4-dichloro-phenyl)-ethyl]-ethyl-carbamoyl}-methyl)-carbamoyl]-4-guanidino-butylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (R)-N-{(S)-2-(3,4-dichloro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-hydroxy-3-phenyl-propionamide trifluoroacetate

Methyl (2R)-3-(3,4-Dichlorophenyl)-2-[(2-Methylpropan-2-yl)Oxycarbonylamino]Propanoate置于水,Lithium Hydroxide体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 6.0H,反应生成N-叔丁氧羰基-D-3,4-二氯苯丙氨酸
参考文献:Discovery Of Pyrrolopyrimidine Inhibitors Of Akt
标题:Discovery Of Pyrrolopyrimidine Inhibitors Of Akt
摘要:The Discovery And Optimization Of A Series Of Pyrrolopyrimidine Based Protein Kinase B (Pkb/akt) Inhibitors Discovered Via Hts And Structure Based Drug Design Is Reported. The Compounds Demonstrate Potent Inhibition Of All Three Akt Isoforms And Knockdown Of Phospho-Pras40 Levels In Lncap Cells And Tumor Xenografts. (C) 2010 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2010.08.053