CAS: 120066-54-8; [10-[2-(Hydroxy-?O)Propyl]-1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetato(3-)-?N1,?N4,?N7,?N10,?O1,?O4,?O7]-Gadolinium

10-(2-羟基丙基)-1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸 反应生成钆特醇
参考文献:Inorg. Chem. 1991,30,1265-1269
标题:Inorg. Chem. 1991,30,1265-1269

专利信息

专利号:US-2025051292-A1
优先权日:2021-12-14
标题 :Process for manufacturing a mixture comprising a dimeric macrocycle intermediate of a gadolinium complex
发明人：GAZZETTO SONIA; BOI VALERIA; BANIN ANDREA; BARALE ANDREA
权利人:BRACCO IMAGING SPA
摘要:The present invention relates to a process for the manufacturing of a mixture comprising the intermediate 1-[bis[2-hydroxy-3-[4,7,10-tris[2-(1,1-dimethylethoxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododec-1-yl]propyl]amino]-1-deoxy-D-glucitol. Such intermediate is useful for the synthesis of the dimeric gadolinium complex [μ-[1-[bis[2-(hydroxy-κO)-3-[4,7,10-tris[(carboxy-κO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-κN 1 ,κN 4 ,κN 7 ,κN 10 ]propyl]amino]-1-deoxy-D-glucitolate(6-)]]digadolinium complex, which can be employed as a contrast agent in the field of diagnostic imaging, and in particular of Magnetic Resonance Imaging (MRI).

专利号:US-2022118123-A1
优先权日:2019-02-22
标 题 :Combination of ar antagonists and targeted thorium conjugates
发明人：HAMMER STEFANIE; HAGEMANN URS BEAT; HAENDLER BERNARD; LEJEUNE PASCALE; ZITZMANN-KOLBE SABINE; SCHATZ CHRISTOPH; KARLSSON JENNY
权利人:BAYER AG; BAYER AS
摘要:The present invention covers combinations of at least two components, component A and component B, comprising component A being PSMA-TTC, and component B being an antiandrogen selected form AR antagonists such as from cyproterone acetate, bicalutamide, flutamide, nilutamide, enzalutamide, apalutamide, darolutamide or keto-darolutamide, or an AR degrader such as ARV-110, or an ARN-terminal domain binder such as EPI-506, or an antisense oligonucleotide that reduces AR expression such as EZN-4176 or AZD-5312, or an androgen synthesis inhibitor such as abiraterone, particularly abiraterone acetate, seviteronel, galeterone, orteronel or ketoconazole, or a dual AR antagonist and androgen synthesis inhibitor such as ODM-204. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of a hyper-proliferative disease.

专利号:US-2022242885-A1
优先权日:2021-02-01
标 题 :Synthesis methods and compositions of low intermediate and low dichelate intermediate contrast agents
发明人：DESLAURIERS RICHARD J; MILBOCKER MICHAEL; LOMBARDO PAUL
权利人:INVENTURE LLC
摘要:Macrocyclic gadolinium-based contrast agents (GCA) are synthesized by pathways characterized by the formation of a sequence of metastable complexes before obtaining the final stable complex. Commercial macrocyclic GCAs contain unstable metastable complexes. These metastable species quickly release free Gd3+ ions upon delivery into the body. Aqueous or dry/solid GCA with near zero metastable species content and methods of synthesizing the same are disclosed.

专利号:US-2016138027-A1
优先权日:2013-03-14
标 题:Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1)
发明人：GAN LIN; MEYER TOBIAS
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods for treating diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mTORC1) are disclosed. The invention is based in part on the discovery that protein mediator of amino acid signaling to mTOR (MORTOR) is involved in amino acid-induced translocation of mTORC1 to lysosomes where MORTOR forms a signaling complex with mTORC1, Ragulator, and Rag GTPases, which controls protein synthesis. In particular, the invention relates to the use of antagonists of MORTOR for treating diseases and conditions associated with dysregulation of mTORC1. Downregulation of expression of MORTOR by RNA interference has been shown to reduce cell proliferation of cancerous cells and may be useful for treating cancer.

专利号:US-2019292206-A1
优先权日:2018-03-22
标 题 :Gadolinium complex, method for synthesis of the gadolinium complex, and mri contrast agent including the gadolinium complex

专利号:US-10759817-B2
优先权日:2018-03-22
标 题:Gadolinium complex, method for synthesis of the gadolinium complex, and MRI contrast agent including the gadolinium complex
发明人：CHANG YONG MIN
权利人:KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND
摘要:Disclosed are a gadolinium complex with a high relaxibity at a high magnetic field, a method for synthesizing the complex, and an MRI contrast agent containing the gadolinium complex. The gadolinium complex may be expressed as a Chemical Formula 1: