CAS: 128196-01-0; (S)-1-(3-(Dimethylamino)Propyl)-1-(4-Fluorophenyl)-1,3-Dihydroisobenzofuran-5-Carbonitrile (Escitalopram Impurity)

上下游产品

西酞普兰 1-(3-Dimethylamino-Propyl)-1-(4-Fluoro-Phenyl)-1,3-Dihydro-Isobenzofuran-5-Carbonitrile 59729-33-8
1-(4-氟苯基)-1-[3-(甲基氨基)丙基]-1,3-二氢-2-苯并呋喃-5-甲腈 (+)-Desmethylcitalopram 144025-14-9
(S)-N-Didemethyl-Citalopram 166037-78-1
(S)-1-(3-(Dimethylamino)Propyl)-1-(4-Fluorophenyl)-3-Oxo-1,3-Dihydrobenzofuran-5-Isonitrile
(+)-(R)-4-(4-Dimethylamino-1-(4'-Fluorophenyl)-1-Hydroxybutyl)-3-(Hydroxymethyl)-Benzonitrile 481047-48-7
(-)4[4-(二甲胺基)-1-(4-氟苯基)-1-(羟基丁基)-3-(羟基 甲基)氰苯.氢溴酸盐 (-)-(S)-4-(4-Dimethylamino-1-(4'-Fluorophenyl)-1-Hydroxybutyl)-3-(Hydroxymethyl)-Benzonitrile 488787-59-3
4-(4-二甲胺基-1-对氟苯基-1-羟基丁基)-3-(羟甲基)苯腈 4-[4-(Dimethylamino)-1-(4-Fluorophenyl)-1-Hydroxybutyl]-3-(Hydroxymethyl)Benzonitrile 103146-25-4
(S)-(+)-3-(5-溴-1-(4-氟苯基)-1,3-二氢异苯并呋喃-1-基)-N,N-二甲基丙烷-1-胺 (S)-(+)-3-(5-Bromo-1-(4-Fluorophenyl)-1,3-Dihydroisobenzofuran-1-yl)-N,N-Dimethylpropan-1-Amine 488148-14-7 Succinic Acid Mono-{5-Cyano-2-[(S)-4-Dimethylamino-1-(4-Fluorophenyl)-1-Hydroxybutyl]-Benzyl} Ester 863116-45-4 Tert-Butyl ((4S)-4-(4-Cyano-2-(((Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Phenyl)-4-(4-Fluorophenyl)-4-Hydroxybutyl)(Methyl)Carbamate 1352344-90-1

草酸右旋西酞普兰置于ammonium Hydroxide体系中,用 乙醚,水 用作溶剂,以30.1 G的收率获得依他普仑
参考文献: New Salt And Solid State Forms Of Escitalopram[fr] Nouveau Sel Et Formes à L'état Solide D'Escitalopram
标题: New Salt And Solid State Forms Of Escitalopram[fr] Nouveau Sel Et Formes à L'état Solide D'Escitalopram
摘要:本公开涉及氟西汀的新盐及其固态形式,其制备方法,药物组合物以及使用方法.

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2006030625-A1
优先权日:2004-08-06
标 题 :Dietary neurotransmitter precursors for balanced synthesis of neurotransmitters
发明人：HART CHERYLE RAM; GROSSMAN RONALD S; RAM HERBERT
权利人:HART CHERYLE RAM; GROSSMAN RONALD S; RAM HERBERT
摘要:Dietary supplements for treating a neurotransmitter deficiency include one or more precursors of the deficient neurotransmitter and a cofactor for activating in vivo enzymatic synthesis of the deficient neurotransmitter. The dietary supplements can also include an appropriate neurotransmitter, such as an amino acid. When administered through the oral mucosa, increases in levels of the deficient neurotransmitters and relief from deficiency symptoms are obtained.

专利号:US-9981949-B2
优先权日:2008-12-01
标题 :Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine
发明人：AKIREDDY SRINIVASA RAO; BHATTI BALWINDER SINGH; CUTHBERTSON TIMOTHY J; DULL GARY MAURICE; MILLER CRAIG HARRISON; MITCHENER JR JOSEPH PIKE; MUNOZ JULIO A; OTTEN PIETER ALBERT
权利人:OYSTER POINT PHARMA INC
摘要:The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.

专利号:US-8604191-B2
优先权日:2008-12-01
标 题:Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3YLVINYL)pyrimidine
发明人：AKIREDDY SRINIVASA RAO; BHATTI BALWINDER SINGH; CUTHBERTSON TIMOTHY J; DULL GARY MAURICE; MILLER CRAIG HARRISON; MITCHENER JR JOSEPH PIKE; MUNOZ JULIO A; OTTEN PIETER ALBERT
权利人:AKIREDDY SRINIVASA RAO; BHATTI BALWINDER SINGH; CUTHBERTSON TIMOTHY J; DULL GARY MAURICE; MILLER CRAIG HARRISON; MITCHENER JR JOSEPH PIKE; MUNOZ JULIO A; OTTEN PIETER ALBERT; TARGACEPT INC
摘要:The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-yl)pyrimidine, novel salt forms, and novel polymorphic forms of these salts.

专利号:US-2008199922-A1
优先权日:2005-06-22
标题 :Chemoenzymatic Process for the Synthesis of Escitalopram
发明人：COTTICELLI GIOVANNI; SALVETTI RAUL; BERTONI CHIARA
权利人:ADORKEM TECHNOLOGY SPA
摘要:A process is described for the preparation of escitalopram and the pharmaceutically acceptable salts thereof starting from 5-cyanophthalide by a process which provides an enantioselective enzymatic deacylation reaction of a complex of the formula (IV) where R represents a C 1 -C 4 alkyl residue or an aryl residue under the action of an esterase from Aspergillus niger.

专利号:US-7598399-B2
优先权日:2005-11-30
标 题 :Methods for synthesis of 3-amino-1-arylpropyl indoles
发明人：CONNOLLY TERRENCE JOSEPH; FARRELL ROBERT P; HUMPHREYS ERIC ROY; LYNCH STEPHEN M; SARMA KESHAB
权利人:ROCHE PALO ALTO LLC
摘要:A method comprising:n hydrogenating an indole propionamide compound of formula h nn nwith vitride, to form an aminopropyl indole compound of formula in n nwherein m, Ar, R 1 and R 2 are as defined herein. The compounds prepared by the method of the invention are useful as monoamine reuptake inhibitors useful for treatment of CNS indications.