专利号:WO-9710221-A1 优先权日:1995-09-15 标 题:Synthesis of quinazolinone libraries 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TORREY PINES INST 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:WO-9834113-A1 优先权日:1997-02-04 标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein 发明人:OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; HOUGHTEN RICHARD A; BLONDELLE SYLVIE E; SCHONER CHRISTA C 权利人:TREGA BIOSCIENCES INC 摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.
专利号:US-7238823-B2 优先权日:2005-06-30 标 题 :Platinum complexes with mononitrile-containing ligands 发明人:XIAO ZEJUN; HAUSHEER FREDERICK H; PETLURU PAVANKUMAR 权利人:BIONUMERIK PHARMACEUTICALS INC 摘要:Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L 1 and L 2 ) which can be hydrolyzed in vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.
专利号:CN-113861119-A 优先权日:2021-11-23 标题:A kind of method for cobalt-catalyzed synthesis of quinoline and quinazoline compounds
专利号:US-7569606-B2 优先权日:2006-01-26 标 题 :Platinum complexes with mononitrile-containing ligands 发明人:XIAO ZEJUN; HAUSHEER FREDERICK H; PETLURU PAVANKUMAR 权利人:BIONUMERIK PHARMACEUTICALS INC 摘要:Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L 1 and L 2 )which can be hydrolyzed iii vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.
专利号:WO-9811438-A1 优先权日:1996-09-13 标题 :Synthesis of quinazolinone libraries and derivatives thereof
[参考文献]: A P Kumar, Et Al. Vibrational Analysis Of Substituted Benzonitriles. Iii. Transferability Of Force Constants--The Case Of Some Halogeno-, Methoxy- And Nitro-Benzonitriles. Spectrochim Acta A Mol Biomol Spectrosc. 1997 Oct 15;53A(12):2041-8. [参考文献]: Guillermo Diaz Fleming, Et Al. Theoretical Surface-Enhanced Raman Spectra Study Of Substituted Benzenes Ii. Density Functional Theoretical Sers Modelling Of O-, M-, And P-Methoxybenzonitrile. Spectrochim Acta A Mol Biomol Spectrosc. 2008 Dec 1;71(3):1074-9.
合成参考文献
摘要:Bertus, P.; Boeda, F.; Pearson-Long, M. S. M., Science of Synthesis Knowledge Updates, (2012) 1, 41. 摘要:Glushkov, V. A.; Shklyaev, Yu. V., Science of Synthesis Knowledge Updates, (2018) 3, 232. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 374. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 392. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 388.