CAS: 155-90-8; 2-Amino-4-Methoxypyrimidine

相似化合物

36315-01-2 66131-71-3 304454-19-1

上下游产品

CAS号5734-64-5 2-氨基-4-氯-6-甲氧基嘧啶 | CAS号36082-45-8 2-氨基-5-溴-4-甲氧基嘧啶 | CAS号73183-34-3 双戊酰二硼 | CAS号67-56-1 甲醇 | CAS号3993-78-0 2-氨基-4-氯嘧啶 | CAS号124-41-4 甲醇钠 | CAS号3934-20-1 2,4-二氯嘧啶 | CAS号43212-41-5 2,4-二氯-6-甲氧基嘧啶 | CAS号7781-26-2 5-溴-4,6-二氯嘧啶-2-胺 | CAS号89322-66-7 2-氨基-5-碘-4-甲氧基嘧啶 | CAS号108-53-2 异胞嘧啶 | CAS号36082-45-8 2-氨基-5-溴-4-甲氧基嘧啶 | CAS号156-81-0 2,4-二氨基嘧啶

在 Ammonium Hydroxide体系中,用 水,乙腈 用作溶剂,化学反应 2.0H,以22 Mg的收率获得2-氨基-4-甲氧基嘧啶
参考文献:通过焓控制的亲核官能化对嘧啶进行 C2 选择性,官能团发散胺化
标题:通过焓控制的亲核官能化对嘧啶进行 C2 选择性,官能团发散胺化
摘要:杂芳胺的合成因其在小分子发现中的重要性而一直是有机化学中的一个重要课题.特别是,2-氨基嘧啶代表了一种在生物活性分子中普遍存在的高度特权结构基序,但通过直接功能化引入嘧啶 C2-N 键的一般策略是难以捉摸的.在这里,我们描述了一种用于位点选择性 C-H 官能化的合成平台,该平台提供嘧啶基亚胺盐中间体,然后可以原位转化为各种胺产物.基于机制的试剂设计允许嘧啶的 C2 选择性胺化,开辟了位点选择性杂芳基 C-H 官能化的新范围.
Doi:10.1021/jacs.1C13373

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-11980630-B2
优先权日:2017-07-31
标 题 :Flex-nucleoside analogues, novel therapeutics against filoviruses and flaviviruses
发明人：RADTKE KATHERINE L
权利人:UNIV MARYLAND
摘要:The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:JP-2000281611-A
优先权日:1999-03-30
标 题 :Synthesis of phenolic compound having protected hydroxy group, and radioactive ray-sensitive composition by using the same